Browsing Human- und Zahnmedizin by Referee "Koch, Jan C. PD Dr."
Now showing items 1-12 of 12
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Veränderungen der Ultrastruktur des axonalen Cytoskeletts während der akuten axonalen Degeneration
(2025-02-06)The ultrastructure of the cytoskeleton of axons shows a periodically arranged sub-plasmalemmal membrane skeleton. It is formed by ring-shaped actin filaments and associated membrane proteins and is connected by spectrin ... -
Effects of overexpression of the ALS associated protein TDP-43 and its mutant on the axonal and somal proteome in compartimentalized primary cortical neurons of rats
(2024-08-22)Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease of the motor nervous system. During its course, the function of the upper and lower motor neurons is predominantly lost. It is a very severe ... -
Einfluss von bilateralen wachstumsfreundlichen Implantaten zur Behandlung von Kindern mit spinaler Muskelatrophie auf die Rippenabgangswinkel, das Thorax- und Lungenvolumen
(2024-08-16)Introduction: This study analyzed the effects of bilateral growth-friendly spinal implants (GFSI) on the thorax and lungs in children with spinal muscular atrophy (SMA) and neuromuscular scoliosis. Methods: The data from ... -
Neuronal glucose metabolism in amyotrophic lateral sclerosis
(2024-06-28)ALS is a rapidly progressing neurodegenerative disease characterized by motor neuron death ultimately leading to paralysis and respiratory failure. While a great deal of progress has been made deciphering the underlying ... -
Axonal transport of autophagosomes in models of neurodegeneration in vitro and in vivo
(2023-12-14)Axonal degeneration is a prevalent hallmark of normal aging, trauma, and neurodegenerative CNS diseases. As an early event, it usually occurs prior to neuronal cell death, which has potential therapeutic implications. ... -
Cytoskeletal assembly in axonal outgrowth and regeneration analyzed using STED microscopy
(2023-11-17)The cytoskeleton is essential for axon outgrowth and regeneration. It must be able to tolerate mechanical force and torsion while also allowing for adaptation and response to trauma or injury, such as axonal lesions. Recent ... -
Der Effekt einer akuten Sportintervention auf die Stressreaktion bei Patient:innen mit Posttraumatischer Belastungsstörung
(2022-12-14)In this study we investigated the effect of an acute exercise intervention on the stress response of patients with posttraumatic stress disorders, measured with several parameters such as Cortisol for HPA-axis, heart rate ... -
Analyse der intrakraniellen Druckmessung mittels implantierbarer Telemetrie-Sonden bei Patienten mit Hydrozephalus oder idiopathischer intrakranieller Hypertension
(2022-04-04)Background: In some patients with hydrocephalus or idiopathic intracranial hypertension, symptoms continue after shunt operation. In these cases, elevated or lowered intracranial pressure (ICP) can be handled with adjustments ... -
Der Einfluss von humanem Wildtyp-Alpha-Synuclein und seinen Mutationen A30P und A53T auf das Neuritenwachstum primärer dopaminerger Mittelhirnneurone der Ratte
(2021-01-11)Parkinson´s disease (PD) is the second most common neurodegenerative disease with increasing prevalence worldwide. Despite extensive research, current treatments of PD remain purely symptomatic while neuroprotective and ... -
Der Einfluss von humanem α-Synuclein-Wildtyp und der Mutanten A30P und A53T auf die Autophagie und den Transport synaptischer Vesikel in primären Mittelhirnneuronen der Ratte
(2020-09-29)Despite the expanding pathological understanding of Parkinson´s disease (PD) the relevant pathomechanisms are still not completely understood. Previous evidence suggests that disturbed cellular proteindegradation (autophagy) ... -
Live-Imaging von Kalzium-induzierter axonaler Degeneration in transgenen Mausmodellen des Morbus Parkinson
(2020-07-28)Introduction: In Parkinson’s Disease (PD), damage to axonal terminals precedes the loss of somata, which follows later in a “dying-back” pattern (axonal degeneration). The protein alpha-synuclein (aSyn) and its mutant forms ... -
Transition chronisch neurologisch kranker Jugendlicher des Sozialpädiatrischen Zentrums Göttingen in die Erwachsenenmedizin
(2017-11-28)In medical terminology the term „transition“ denotes the purposeful and planned movement of adolescents with chronical diseases from a child-centred to an adult-centred health-care-system. Many clinical models have been ...