Browsing Human- und Zahnmedizin by Referee "Koch, Raphael PD Dr."
Now showing items 1-4 of 4
-
Mode of action of direct KRAS inhibition and development of KRAS inhibitor-based combination therapies
(2025-08-21)As pancreatic ductal adenocarcinoma (PDAC) has still one of the least favourable survival rates among cancers, better treatment is urgently needed. This thesis aimed to make use of a new class of targeted therapies, the ... -
Funktionelles Apoptose-Profiling zur Weiterentwicklung zielgerichteter Therapien für die adulte T-Zell akute lymphatische Leukämie (T-ALL)
(2025-06-23)T-cell acute lymphoblastic leukaemia is a very aggressive haematological neoplasia characterised by malignantly transformed precursor T-lymphocytes. Considering the poor prognosis and limited treatment options for affected ... -
Einfluss medikamentöser Inhibition der anaplastischen Lymphomkinase auf die Regulation der mitochondrialen Apoptose in ALK+ anaplastisch großzelligen T-Zell Lymphomen
(2024-10-08)T-cell lymphomas are a rare, heterogeneous group of diseases of mature post-thymic T- or natural killer cells with primarily nodal or extranodal manifestation. The anaplastic large cell lymphoma (ALCL) can be classified ... -
Pankreatisch zystische Neoplasien und das orointestinale Mikrobiom: Evaluierung als Biomarker
(2024-09-24)Pancreatic cystic neoplasms (PCN) are mostly benign cystic lesions of the pancreas, which can be a precursor lesion for pancreatic cancer. The risk of malignancy varies widely, depending on the entity of the PCN. Despite ...