Dokumente Human- und Zahnmedizin nach Gutachter "Lakomek, Max Prof. Dr."
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Adherence to paediatric antiretroviral therapy in South Africa
(2009-06-03)Introduction. In South Africa, the HIV epidemic has risen sharply in numbers over the past decade, and a growing number of children are treated with antiretroviral therapy. This study aimed ... -
Einfluss der ACE-Hemmer-Therapie auf das Fortschreiten der Niereninsuffizienz bei Patienten mit Alport-Syndrom
(2012-03-19)The Alport Syndrome (AS) is a hereditary progressive kidney disease. Genetic mutations lead to structural and functional defects of the Type-IV collagen. This collagen is an essential part of the glomerular basement ... -
Etablierung und Validierung der RNA-Interferenzmethode am Beispiel Apoptose-relevanter Gene
(2012-07-05)Specific inhibition of gene expression is becoming an increasingly important method for experimental strategies to influence tumor growth on a molecular level. In this work, we investigated the role of individual molecules ... -
Expressionshemmung von MCM3 in Glioblastomen durch RNA-Interferenz
(2015-03-06)This work shows effects of specific suppression of MCM3-protein, which is upregulated in human glioblastoma cells (U87MG), by using RNAi. The effects on metabolic activity, cell viability, proliferation, cell cycle and ... -
Generierung von Antikörper-Bibliotheken und Selektion von Antikörpern gegen die Integrine αvβ5 und α5β1 mittels Phagen-Display-Technologie
(2008-10-23)Angiogenesis, the formation of new blood vessels, plays a major role in controlling growth and survival of tumours. As cell adhesion molecules, integrins directly influence the function and ... -
Präemptive Therapie mit Angiotensin-Converting-Enzyme-Inhibitoren verzögert Nierenersatztherapie bei heterozygoten Mutationsträgerinnen mit X-chromosomalem und autosomal-rezessivem Alport-Syndrom
(2013-02-08)The Alport syndrome (AS) is a hereditary chronic kidney disease which is characterized by ultrastructural lesions of the glomerular basement membrane (GBM), hearing loss and ocular changes. The cause of AS are various ... -
Prognose von Patienten mit Alport-Syndrom unter Berücksichtigung einer medikamentösen Intervention und verschiedener Nierenersatzverfahren
(2015-01-20)Alport syndrome is a hereditary kidney disease which typically has a progressive course (Alport 1927). Several extrarenal symptoms such as inner ear hearing loss and a specific eye disease known as „Lenticonus“ can also ... -
Retrospektive Analyse klinischer Daten von 358 Patienten mit hereditärer Sphärozytose
(2011-09-20)This, at these days most extensive, german study analyses in detail 358 patients with hereditary sphaerocytosis (HS) in a retrospective-descriptive way, concentrating on diagnostic tools ... -
Untersuchung zur Verzögerung der terminalen Niereninsuffizienz durch die Therapie mit ACE-Hemmern bei Patienten mit Alportsyndrom in Belgien und Spanien
(2012-03-02)Alport syndrome is a hereditary disease caused by mutations in type IV collagen genes, which inevitably leads to end-stage renal failure. In the context of the non-interventional European ... -
Wenn Kinder anderer Meinung sind - Die ethische Problematik von Kindeswohl und Kindeswille in der Kinder- und Jugendmedizin
(2013-10-09)In pediatrics, an ethical conflict may eventually arise between the best interest of the child and the child´s choice, in particular if the child refuses a medically indicated therapy. Does the before-mentioned setting ...