Browsing Human- und Zahnmedizin by Referee "Lutz, Susanne Prof. Dr."
Now showing items 1-15 of 15
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Neodym:YAG-Lasertherapie mukoider Dorsalzysten: Klinische Wirksamkeit und Effekte in einem 3D-Gewebemodell
(2025-02-14)This study evaluates Nd:YAG-laser treatment as a novel therapeutic option for mucoid dorsal cysts, for which no standard procedure currently exists. In the first part, the clinical efficacy and potential of this new treatment ... -
Evaluation of the antifibrotic potential of Serelaxin in two experimental models of cardiac fibrogenesis
(2023-08-28)This study is based on the finding that Relaxin was identified in Rln1 gene knockout mice as a naturally occurring regulator of collagen turnover in the heart (Du et al. 2003). Additionally, in a model of spontaneously ... -
Konstruktion eines vaskularisierten 3D-Zellkultursystems zur Bildung künstlicher Knochenkonstrukte und Untersuchung des Einflusses von Kollagen Typ I auf die osteogene Differenzierung von humanen mesenchymalen Stammzellen
(2023-07-17)Osteogenesis is a complex process of differentiation where osteogenic stem cells interact with vessels, cartilage cells, others tissue types and extracellular matrix. This process is also affected by nutritive, structural ... -
Funktionelle Charakterisierung von Substitutionsmutationen in Position 566 der Linker-Domäne des onkogenen Transkriptionsfaktors STAT3
(2023-06-08)In this work, the role of two missense mutations in position 566 of the human transcription factor STAT3 (signal transducer and activator of transcription) in relation to the activation of the JAK/STAT signalling pathway ... -
Reevaluation der potenziell onkogenen, Lymphom-assoziierten Missense-Mutation D427H im STAT3-Molekül
(2023-01-06)The transcription factor STAT3 (signal transducer and activator of transcription 3) promotes cell proliferation, immunomodulation, and maintenance of a stem cell state, such that its constitutive activation in cells carries ... -
Über die potenziell kardioprotektive Rolle des Hitzeschockproteins A4
(2020-08-06)Background: The protein quality control (PQC) plays a crucial role in cellular homeostasis. Accumulation of misfolded proteins can lead to a loss of function of cardiomyocytes and thus can contribute to heart failure. A ... -
Charakterisierung der Punktmutante E449A in der DNA-Bindedomäne des humanen Transkriptionsfaktors STAT1
(2020-06-09)Signal transducers and activators of transcription (STAT) proteins play a key role in the Janus Kinase(JAK)/STAT signaling pathway. Since their discovery over twenty years ago, new evidence about the complex interaction ... -
Die Bedeutung der Coiled-coil-Domäne für die Inaktivierung des Transkriptionsfaktors STAT1
(2020-05-07)Heterozygous gain-of-function (GOF) mutations in the transcription factor STAT1 (signal transductor and activator of transcription 1) result in increased expression of cytokine-regulated target genes. The abnormally high ... -
Nachweis und Lokalisation der regulatorischen Proteine RGS4 und RGS10 innerhalb osteoarthrotischen Knorpels und chondrogener Progenitorzellen
(2020-01-27)In this study, for the first time the regulatory proteins RGS4 and RGS10 could be detected in chondrogenic progenitor cells (CPCs) and in cartilage samples from knees which had been removed during TEP implantation in the ... -
Die Reorganisation des Aktinzytoskeletts in Hypoxie: Neue Erkenntnisse über die Rolle von ArhGAP29
(2019-08-15)Cells can adapt to hypoxia by various mechanisms. Most of them are mediated by HIF-1, the main transcription factor in hypoxia. It was shown that L929 fibroblasts cultivated in hypoxia (1% O2) showed morphological differences ... -
The role of tubulin acetylation in cardiac fibroblasts
(2018-09-25)Cardiac fibroblasts and their activation upon cardiac damage play a key role in pathological cardiac remodelling and the development of cardiac fibrosis. This thesis investigates the role of α-tubulin acetylation in cardiac ... -
Einfluss von Ranolazin und Flunarizin in Kombination mit d-Sotalol auf getriggerte Arrhythmien im isolierten Kaninchenherzen
(2017-09-06)Torsades de pointes (TdP) tachycardias are triggered, polymorphic ventricular arrhythmias arising from early afterdepolarizations (EADs) and increased dispersion of repolarization. Ranolazine is a new agent which reduces ... -
Das purinerge System im vorderen Telenzephalon der Kaulquappe von Xenopus laevis und dessen Beteiligung an der Verarbeitung von Duftstoffantworten
(2017-03-08)The anterior part of the telencephalon of Xenopus laevis consists mainly of the olfactory bulb and the lateral ventricles which expand deep into the anterior telencephalon. The periventricular zone generates new olfactory ... -
Angiotensin II induziert Nox 2 -abhängig Arrhythmien in ventrikulären Kardiomyozyten der Maus
(2015-10-28)Heart failure and cardiac arrhythmias are prevalent diseases which occure mainly in older patients. With regard to the demographic change their importance will even increase in the nexts decades. Mechanisms of heart failure ... -
Functional and Mutational Analysis of Kinase Domain of the Giant Protein Titin
(2012-06-20)The giant filamentous muscle protein titin spans half of the sarcomere. Through its tight association with the thick filament, its elastic elements at the I-band, its connection to the cytoskeleton components, and its ...