Dokumente Human- und Zahnmedizin nach Gutachter "Maier, Lars S. Prof. Dr."
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Akuter ST-Strecken-Hebungsinfarkt (STEMI) bei Patientinnen und Patienten mit zusätzlich chronischem Verschluss in einem Nicht-Infarkt-Gefäß: klinische Relevanz und prognostische Bedeutung
(2018-04-06)The topic of "chronic total coronary occlusion" (CTO) is in focus, as in recent years, techniques have been developed that make it possible to achieve revascularization by percutaneous coronary intervention (PCI) even in ... -
Auswirkungen des neuartigen CaMKII-Inhibitors SMP-114 auf das diastolische SR Ca2+-Leck und die elektromechanische Kopplung isolierter Herzmuskelzellen
(2015-10-28)The effects of the novel CaMKII inhibitor on Ca2+ handling and EC coupling of isolated murine cardiomyocites were evaluated using epifluorescence and confocal microscopy. SMP-114 warranted a significant reduction in diastolic ... -
Die Bedeutung der Ca2+/Calmodulin-abhängigen Proteinkinase IIδ für die zytosolische Natrium- und Kalziumüberladung sowie Arrhythmogenese in Herzmuskelzellen
(2013-01-14)The expression and activity of the Ca2+/Calmodulin-dependent protein kinase IIδ (CaMK IIδ) is increased in heart failure and correlates with progression of disease. Also, reactive oxygen species (ROS), which are increasingly ... -
Einfluss der Calstabin2-Mutante FKBP12.6D37S in gesunden Mauskardiomyozyten und in einem transgenen Herzinsuffizienzmodell, das die Kalzium/Calmodulin-abhängige Proteinkinase IIδc überexprimiert
(2011-08-24)In heart failure (HF) calcium/calmodulin-dependent protein kinase IIdc (CaMKIIdc) and protein kinase A (PKA) are activated and promote diastolic sarcoplasmic reticulum (SR) calcium (Ca) ... -
Einfluss des α1(I)-Kollagens auf die Aktionspotentiale von frühen aus embryonalen Stammzellen differenzierten Kardiomyozyten
(2011-07-04)Type-I collagen is the main component of the cardiac extracellular matrix (ECM). Knockout (KO) of α1(I)-collagen is embryonically lethal. In-vitro-differentiation of cardiomyocytes from ... -
Extramitochondriale und mitochondriale Produktion reaktiver Sauerstoffspezies im Hippokampus MeCP2-defizienter Mäuse
(2014-05-20)Rett syndrome is a neurodevelopmental disorder caused by mutations in the X-chromosomal MECP2 gene encoding for the transcriptional regulator methyl CpG binding protein 2 (MeCP2). Rett syndrome is associated with cognitive ... -
Funktionelle Charakterisierung der Kalzium/Calmodulin-abhängigen Proteinkinase-II-δ (CaMKIIδ)-Knockout-Maus
(2013-12-03)CaMKII, the Ca2+/Calmodulin-dependent protein kinase-II, is a multifunctional serine/threonine protein kinase that is a central regulator of cardiomyocyte excitation-contraction-coupling. Several isoforms exist. In the ... -
Funktionelle Charakterisierung neu entwickelter SERCA2a-Modulatoren an humanem Myokard und isolierten Herzmuskelzellen der Ratte
(2018-03-12)Decreased expression of cardiac sarcoplasmic calcium ATPase SERCA2a is known to play an important role in the pathogenesis of chronic heart failure. Thus stimulation of SERCA2a attracted increased attention as a promising ... -
Die Herzfunktion während milder Hypothermie bei anästhesierten Schweinen: gesteigerte Inotropie auf Kosten einer diastolischen Dysfunktion
(2012-04-05)While the induction of mild hypothermia (MH) has become the guideline therapy to attenuate hypoxic brain injury after out-of-hospital cardiopulmonary resuscitation, the cardiac effects of hypothermia are controversially ... -
Die Rolle der Kalzium-Calmodulin-abhängigen-Proteinkinase II δc (CaMKIIδc) bei der Radikal-vermittelten Zytotoxizität in isolierten ventrikulären Kaninchenmyozyten
(2010-06-09)Expression levels of Ca/calmodulin kinase II (CaMKII) are enhanced in heart failure (HF). Failing cardiomyocytes are more susceptible to reactive oxygen species (ROS)-induced injury. It has ... -
Die Rolle des späten Natrium-Stroms bei der Kalzium-Calmodulin-abhängigen ProteinkinaseIIδC (CaMKIIδC)-induzierten Herzinsuffizienz und beim chronischen Vorhofflimmern
(2012-06-21)Ranolazine is a drug that was introduced for antianginal therapy in Germany in 2008. Its effects are explained by inhibition of the so called „late Na+-current“ in the cardiomyocyte. Contrary to the „fast Na+-current“, ... -
Transport- und Behandlungszeiten im Herzinfarktnetzwerk Göttingen
(2013-11-26)Acute myocardial infarction is one of the leading causes of death worldwide. Evidence shows that prompt percutaneous coronary intervention (PCI) reduces mortality and improves outcome in patients with ST-segment-elevation ... -
Untersuchungen von Phospho-AMPK α, VEGF-A und VEGF-R2 im Myokard sowie Analysen von morphologischen Veränderungen im Modell der chronischen Herzinsuffizienz induziert durch sequentielle, repetitive koronare Mikroembolisation an der Spezies Schaf
(2011-08-15)Subsequent to establishing a stable and reproducible animal model of chronic heart failure (comparable NYHA III) induced by multiple sequential coronary microembolization in sheep we ...