Browsing Human- und Zahnmedizin by Referee "Nau, Roland Prof. Dr."
Now showing items 1-20 of 26
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Activin A und Follistatin bei bakteriellen Infektionen - Der Einfluss von Activin A auf Mikrogliazellen in vitro und der Einfluss von Follistatin auf den Verlauf einer E. coli-K1-Sepsis im Mausmodell
(2012-10-01)High concentrations of Activin A and Follistatin can be found in the cerebrospinal fluid (CSF) of patients with bacterial meningitis. Patients suffering from a sepsis have increased concentrations of Activin A and Follistatin ... -
Additiver Mikroglia-vermittelter Neuronenschaden durch β-Amyloid und bakterielle Toll-like-Rezeptor-Agonisten in primären murinen Mikroglia-Neuronen-Kokulturen. Entwicklung eines Auswertungsalgorithmus zur Quantifizierung des Neuronenschadens mit Hilfe einer Software zur objektorientierten Bildanalyse
(2012-06-06)Activated microglia is considered to be involved in the progression of Alzheimer´s dementia (AD). We investigated the effect of Aβ40 and exogenous agonists of TLR1/2 [Pam3CSK4] and TLR4 [LPS] on neurons in primary ... -
Anwendung von Inhalatoren und hierdurch bedingte Symptomkontrolle sowie Verbesserung der Lungenfunktion bei geriatrischen Patienten mit chronisch-obstruktiver Lungenerkrankung
(2022-03-08)Purpose The use of inhalers requires a high degree of fine motor skills and coordination, which is particularly difficult for elderly patients suffering from chronic-obstructive pulmonary disease (COPD). Many of these ... -
Beeinflussung der Phagozytose von Pneumokokken durch Mikrogliazellen mit Anticholinergika
(2013-12-16)Streptococcus pneumoniae is the most common pathogen causing bacterial meningitis. Despite all efforts using the treatments available, pneumococcal meningitis proves fatal in 25 % of cases. Increasing resistance to ... -
Effekt einer Palmitoylethanolamid-Prophylaxe auf alte oder neutropenische Mäuse nach intrazerebraler E. coli-Infektion
(2020-02-19)Easy-to-achieve interventions to promote healthy longevity are desired to diminish the incidence and severity of infections, as well as associated disability upon recovery. The dietary supplement palmitoylethanolamide ...
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Einfluss der Gebrechlichkeit auf Morbidität und Mortalität nach kathetergestützter Aortenklappenimplantation (TAVI)
(2017-06-15)Background: Transcatheter aortic valve implantation (TAVI) represents a less invasive treatment option for elderly patients. Therefore, we aimed to determine the impact of frailty measured by Katz Index of Activities of ... -
Einfluss einer intrazerebralen Infektion mit Escherichia coli auf den Verlauf der Alzheimer-Demenz im Mausmodell
(2013-06-24)Bacterial infections often worsen the existing neurological symptoms of patients with neurodegenerative diseases such as Alzheimer´s disease. Not only the acute consequences in the sense of a delirium but also the long-term ... -
Einfluss einer intrazerebralen Infektion mit Streptococcus pneumoniae auf den Verlauf der Alzheimer-Demenz im Mausmodell
(2012-06-18)A well known clinical phenomenon, that has been proved in earlier studies, is the deterioration of the clinical-neurological and neuropsychological status in patients with Alzheimer`s disease (AD). Based on this studies ... -
Einfluss systemischer Infektionen auf den Krankheitsverlauf der Alzheimer-Erkrankung im Maus-Modell
(2011-04-28)Neurological symptoms of patients suffering from neurodegenerative diseases such as Alzheimer´s dementia often worsen during infections. An experimental approach to this clinical observation ... -
Einfluss systemischer Infektionen und ihrer Behandlungen auf den Krankheitsverlauf im Maus-Modell des Morbus Parkinson
(2011-06-29)Neurodegenrative diseases such as Parkinson s disease are known to be among the prevalent diseases of this kind. Often they tend to deteriorate during acute infections e.g. excited through ... -
Hausbesuch oder Visite – wie erleben Hausärzte und Pflegekräfte den Heimbesuch im Pflegeheim?
(2017-08-21)Background: The increasing number of residents in nursing homes and their complex health status will challenge medical care and the interaction between nurses and general practition-ers (GPs). The nursing home visit is a ... -
Individuelle Risikofaktoren für C.-difficile-Infektionen bei stationären geriatrischen Patienten im Ev. Krankenhaus Göttingen-Weende
(2023-12-04)Background: C. difficile infection (CDI) is one of the most common nosocomial diseases worldwide. It is transmitted faecal-orally by spores of toxin-producing Clostridioides difficile (TCD), which are particularly prevalent ... -
"Instant Aging"
(2008-02-08)Background: In times of demographic change the treatment of elderly, chronically ill patients becomes a major task for doctors. A teaching method named instant aging was developed in the USA in the seventies. It included ... -
Lumbalpunktionsbefunde bei geriatrischen Patienten im Zeitraum 2008-2011
(2014-12-12)BACKGROUND: The chemical composition of the cerebrospinal fluid (CSF) is age-dependent. METHODS: Routine CSF parameters, the indications for lumbar puncture (LP), and the most frequent complications were retrospectively ... -
Mikroglia-Aktivierung durch Bestandteile von <i>Borrelia burgdorferi sensu lato</i>
(2015-04-15)Lyme disease is the most commonly reported vector-borne illness. It is caused by bacteria of the Borrelia family and transmitted by infected ticks. The outer surface protein C (OspC) and the flagellar protein p41 are common ... -
Neurogenese und Apoptose im hippokampalen Gyrus dentatus bei Autopsiefällen nach hypoxischem Hirnschaden und Subarachnoidalblutung
(2008-11-26)Hypoxic-ischemic encephalopathy (HIE) is the leading cause of morbidity and mortality after successful resuscitation efforts and results in neuronal loss within the neocortex and the ... -
Prävalenz, Antibiotikaresistenz und klinische Relevanz einer Besiedlung des Respirationstraktes mit Streptococcus pneumoniae in einer geriatrischen Klinik
(2020-11-25)Colonization of the pharynx by Streptococcus pneumoniae was studied in 185 in-hospital geriatric patients (median age 81 years) from 29 March 2011 to 22 June 2011. Swabs were plated on blood agar plates. Colonies with a ... -
Prospektive Untersuchung, liquoranalytische Aspekte und Evaluation präanalytischer Bedingungen der CXCL13-Analytik bei Patienten mit akuter Neuroborreliose
(2023-11-17)From July 2014 to August 2019, we examined the clinical characteristics and CSF findings of 72 patients (64 adults, 8 children) with neuroborreliosis as part of a prospective study. According to the modified DGN criteria, ... -
Regulation der mRNA von Toll-Like-Rezeptoren bei experimentellen ZNS-Infektionen
(2012-11-20)Regulation of the mRNA of toll-like receptors in experimental CNS infections Toll-like receptors are sensors and regulators of innate immunity. We investigated the expression of TLRs in experimental infections with ... -
Die Rolle verschiedener Virulenzfaktoren von Streptococcus pneumoniae bei der Meningitis: Untersuchung am Mausmodell
(2015-09-11)The present study examines virulence factors of S. pneumoniae in mouse model. After intracerebral injection virulence factors of D39-wild-type S. pneumoniae were compared with isogenetic derivates. These infection strains ...