Dokumente Human- und Zahnmedizin nach Gutachter "Odoardi, Francesca Prof. Dr."
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Charakterisierung der Oligodendroglia in akuten und chronischen Entmarkungsläsionen der Maus
(2022-09-05)MS is a chronic inflammatory autoimmune disease of the CNS of unknown etiology associated with demyelinating lesions. In addition to chronic demyelinated lesions, there are also remyelinated areas in the CNS. Therapeutically, ... -
Mikroglia-/Makrophagenphänotypen bei humanen Entmarkungserkrankungen (MS, NMO und PML)
(2022-12-14)Multiple sclerosis (MS) is a demyelinating disease of the central nervous system with unknown pathophysiology. Microglia and macrophages accumulate in MS lesions and are discussed as initiators of the cascade of ... -
Multiplexing Mikroskopie für B-Zell-Differenzierung in humanen Multiple Sklerose-Läsionen
(2023-04-13)The aim of this project was to show that with the help of lifetime imaging the specific differentitation of immune cells via their CD expression patterns becomes possible. It was shown that with a double staining of CD20 ... -
Die Rolle des mikroglialen Aryl-Hydrocarbon-Rezeptors in der Cuprizon-induzierten toxischen Entmarkung
(2022-03-28)Multiple sclerosis (MS) is an acquired, inflammatory and neurodegenerative, immune-mediated disease of the central nervous system, primarily involving focally accentuated myelin loss. The detailed etiopathogenesis of MS ... -
Schwannzell-Remyelinisierung bei Neuromyelitis optica
(2023-11-07)Neuromyelitis optica (NMO) is a chronic, autoimmune inflammatory, astrocyte depleting and demyelinating disease of the central nervous system (CNS) and typically affects the spinal cord (myelitis) and optic nerves (neuritis ... -
The effect of Natalizumab on functional properties of monocytes in patients with Multiple Sclerosis
(2024-01-12)Natalizumab (NTZ), a monoclonal antibody against very late antigen-4 (VLA-4), is one of the most efficient therapies to prevent acute relapses in multiple sclerosis (MS). Since VLA-4 is a vital adhesion molecule for ... -
Zeitverlauf und Therapie axonaler Schädigung bei NMO
(2021-10-25)In this doctoral thesis, the time course of axonal damage and the effect of glutamatergic and purinergic receptor antagonists on acute axon pathology were investigated in the focal experimental NMO rat model for the first ...