Dokumente Human- und Zahnmedizin nach Gutachter "Schäfer, Katrin Prof. Dr."
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Bedeutung der Leptinrezeptor-vermittelten Aktivierung des Transkriptionsfaktors STAT3 für die Effekte des Adipokins Leptin auf Blutplättchen
(2014-10-08)Other studies have shown that the leptin receptor is also expressed on platelets (Nakata et al. 1999) and that leptin dose-dependent promotes platelet aggregation. According to these findings there have been many investigations ... -
Bedeutung von Urokinase-Plasminogen-Aktivator für das Wachstum und die Stabilität arteriosklerotischer Gefäßläsionen im Apolipoprotein-E-Knockout-Mausmodell
(2013-10-02)Urokinase plasminogen activator (uPA) is strongly expressed in atherosclerotic lesions, but the overall effect of the protease on plaque composition and growth remains controversial. In the present study, apolipoprotein ... -
Differenzielle Beeinflussung endothelialer Antigene und dynamischer Endothel-Lymphozyten-Interaktionen durch Dimethylfumarat und Monomethylfumarat
(2012-07-11)For years Fumaric acid esters (FAE) have been successfully used in the systemic treatment of severe psoriasis. However, their pleiotropic mode of action is not yet fully understood. To further elucidate the mode of ... -
Einfluss der LDL-Apherese auf die Plaqueentstehung und -stabilität anhand der Konzentrationsbestimmung von Biomarkern
(2012-02-09)LDL-apheresis is thought to exert anti-atherosclerotic effects beyond LDL-cholesterol and Lp(a) reduction. We observe 22 patients undergoing regular LDL-apheresis on a weekly basis by one of the following procedures: DALI ... -
Einfluss der Tie-2 modulierenden Angiopoetine-1 und -2 auf die nephroprotektiven Effekte endothelialer Vorläuferzellen im Mäusemodell des akuten ischämischen Nierenversagens
(2013-03-08)The aim of this study was to evaluate the modulatory effects of Angiopoietin-1 and -2 (Ang-1, Ang-2) on endothelial progenitor cells in murine acute ischemic renal failure. Therefore, C57BI/6N male mices were subjected ... -
Einfluss körperlichen Übergewichts auf die Entwicklung einer kardialen Hypertrophie und die kardialen Umbauprozesse nach experimenteller Myokardischämie
(2011-09-29)Expeditious activation of the IRS-PI3K1A-AKT signaling pathway may result in physiological cardiac hypertrophy, while constant IRS-PI3K1A-AKT stimulation is also associated with the occurrence of pathological forms of cardiac ... -
Der Einfluss von Melatonin auf den nephroprotektiven Effekt von Endothelprogenitorzellen im Mausmodell
(2012-08-24)As part of the study was to investigate whether the nephro-protective effect of endothelial progenitor cells can be enhanced by pretreatment of cells with melatonin. In animal experiments, the left kidney of experimental ... -
Der Einfluss von Tabakentwöhnung auf die funktionellen Eigenschaften von endothelialen Progenitorzellen.
(2012-04-10)Cigarette smoking is the leading cause of preventable death in the western world and the positive effect of smoking cessation on morbidity and mortality is well known. Endothelial progenitor cells (EPC) participate in ... -
Der Einfluß von Leptin auf die Freisetzung endothelialer Vorläuferzellen aus dem Knochenmark
(2014-06-25)Objective− Bone marrow progenitor cells participate in new vessel formation and endothelial repair, and both processes may be modulated by the adipokine leptin. The leptin receptor (ObR) is expressed on hematopoeitic cells, ... -
Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study (RABAMES) - Eine dreiarmige klinische Studie zur Wirksamkeit von Ranibizumab (Lucentis®) im Vergleich zur alleinigen GRID-Laserkoagulation und einer Kombination aus beiden Therapien zur Behandlung des chronischen Makulaödems nach retinalem Venenastverschluss
(2012-12-20)The Ranibizumab for Branch Retinal Vein Occlusion Associated Macular Edema Study (RABAMES) investigated effectiveness and safety of intravitreal applied ranibizumab and grid laser coagulation as well as a combination of ... -
Regulation der Dual-leucine-zipper-kinase (DLK) durch "prädiabetische" Signale in endothelialen HUVEC-Zellen und die Bedeutung der DLK für die Angiogenese in einem Mausmodell
(2013-11-21)Diabetes mellitus and its serious effects on veins and arterys are a major problem in todays society. Important aspects of the disease are microangiopathy and macroangiopathy, which may lead to stroke or death. It is ... -
Rekrutierung von Immunzellen in das perivaskuläre Fettgewebe bei Adipositas – Bedeutung von Leptin
(2018-06-06)Obesity is a well-known risk factor for the development of atherosclerosis and cardiovascular diseases and is associated with hyperleptinemia and a proinflammatory state. Besides the effect of visceral adipose tissue, newer ... -
Untersuchung der systemischen und parakrinen Wirkungen von Leptin auf die Neointimabildung nach experimenteller Gefäßverletzung im Mausmodell
(2016-04-04)Obesity is a very good known risk factor of atherothrombotic complications of the heart and the vessel system. Additionally growing bodyweight and elevated mass of the perivascular adipose tissue (PVAT) and visceral adipose ... -
Die Überexpression der Integrin β5-Untereinheit fördert die proangiogenetischen Fähigkeiten endothelialer Progenitorzellen
(2015-10-09)Angiogenesis is a hallmark of diverse physiological and pathological processes, including ischemia, inflammation, wound healing and tumor growth. The angiogenetic process depends on the proliferation, migration and ... -
Veränderungen kardiovaskulärer Risikofaktoren - mit besonderer Betrachtung von Homocystein und hsCRP - unter drei aktuell diskutierten Ernährungsstrategien zur Gewichtsreduktion: Low carb, Low fat und Low fat with reduced glycemic load
(2007-08-02)In the past years, different dietary strategies have been investigated with regards to their effects on weight loss and cardiovascular risk factors. Now such investigation taking into ...