Dokumente Human- und Zahnmedizin nach Gutachter "Virsik-Köpp, Patricia Prof. Dr."
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Analyse der Rolle des Purin-Rezeptors P2X4 in der Pathophysiologie der Amyotrophen Lateralsklerose durch vergleichende Untersuchung seiner Expression im ALS-Mausmodell und humanen Gewebe
(2012-04-13)The part of purinergic (ATP-) receptors in the pathogenesis of amyotrophic lateral sclerosis (ALS) is so far not thoroughly understood. Current knowledge about the pathogenesis of ALS mostly depends on research with ... -
Die Analyse der Rolle von STAT6 im klassischen Hodgkin-Lymphom
(2011-11-14)Hodgkin`s lymphoma is a common malignancie oft the lymphsystem.The role of STAT6 (signal transducer and activator of transcription) in Hodgkin´s lymphoma is not entirely revealed. The ... -
Analyse von Proteinen und deren Elimination durch drei verschiedene extrakorporale Therapieverfahren der LDL-Apherese bei Patienten mit familiärer Hypercholesterinämie mittels Proteomics-Methoden
(2010-10-20)Background: The aim of our study was the analysis of proteins filtered through several ways of LDL-apharesis by proteomic methods. In order to do so we examined patients with familiar ... -
Ausmaß und therapeutische Relevanz nichtinvasiver Diagnostik in der Palliativmedizin
(2011-10-20)How much diagnostics is required in palliative care? Results from a representative survey and own experiences.Background: Applying diagnostic techniques in palliative care (PC) requires a ... -
Auswirkungen von CYP2D6-, CYP2C9- und CYP2C19-Polymorphismen auf Pharmakokinetik und Wirkungen von Carvedilol
(2011-11-28)Aims: Carvedilol is a beta blocker of the 3rd generation. Still little known is the relation between dependence on the CYP2D6-polymorphism on carvedilol pharmakokinetics and carvedilol pharmacodynamics. Furthermore ... -
Bedeutung der mikrobiellen Transmission im SIV-Rhesusaffen-Tiermodell für die HIV/AIDS-Pathogenese
(2011-02-18)Chronic immune activation is a major aspect of HIV infection and AIDS pathogenesis. Recent data suggests that immune activation is mainly caused by translocation of microbial products through ... -
Die Bedeutung von Erythropoietin und seinem Rezeptor für die Prognose humaner Glioblastome
(2010-05-07)Introduction: erythropoietin (EPO) is a well-known factor of erythropoiesis and is therefore used to treat anemia in neoplastic disease. In addition, EPO exerts neuroprotective effects via EPO-receptor (EPOR) on neuronal ... -
Die Bedeutung von Reelin beim Neuroblastom
(2013-07-05)Neurblastoma is a malignant tumor of early childhood. Its heterogeneity is reflected in its biological properties as well as clinical outcome. In this theses work, I have investigated the function of reelin, an extracellular ... -
Beeinflussung der Knochenparameter und der Knochendefektheilung des osteoporotischen Knochens am Modell der orchidektomierten Ratte durch Vibrationstherapie in Kombination mit Dihydrotestosteron und Östradiol
(2011-11-02)More and more men suffer from osteoporosis with age. High bone fragility and difficult fracture healing are often the result of this disease.The effect of vibration training as a possible ... -
Beeinflussung des Verlaufs von ZNS-Infektionen in immundefizienten Mäusen durch Immunstimulanzien
(2013-10-30)Escherichia coli is the leading cause of Gram-negative meningitis in infants and can also cause meningitis and meningoencephalitis in old and immunocompromised patients. In this doctoral thesis we studied the contribution ... -
Behandlung und Begleitung von Patienten mit Bronchialkarzinom an der Schnittstelle zwischen palliativer Onkologie und Palliativmedizin
(2011-11-09)Background It is widely felt that patients with advanced stages of lung cancer face distinct and exceptional needs with regard to complexity and intensity of symptom burden, the ... -
Bestimmung Zentraler Beziehungskonfliktthemen (nach Luborsky) bei Patienten mit generalisierter Angststörung
(2013-05-13)A number of 45 patients diagnosed „generalized anxiety disorder (GAD)“ were randomly distributed to either manualized cognitive behavioral therapy (CBT) or manualized dynamic psychotherapy (SET). Core conflictual relationship ... -
Biomarker für Oxidativen Stress bei Entzündungsreaktionen: Bedeutung von Genpolymorphismen und Genexpression der NADPH-Oxidase unter pro- und anti-inflammatorischen Bedingungen
(2013-10-18)Background NADPH oxidases (NOX) comprise a multimeric enzyme system expressed in various types of cells and tissues. The most popular isoform is that in leucocytes termed NOX2 according to the big catalytic subunit and ... -
Brüche am MLL-Gen durch apoptotische Vorgänge im Zuge von Probenalterungen im Vergleich zu Brüchen im MLL-Gen bei t-AML
(2011-01-17)We conclude that MLL breakage and religation in the topoisomerase-sensitive bcr, leading to MLL rearrangements (deletions, insertions) in clinical samples, may occur not only after exposure ... -
Die Charakterisierung der induzierbaren Stickstoffmonoxidsynthase im murinen RENCA-Nierenzellkarzinommodell unter spezieller Berücksichtigung tumorassoziierter Makrophagen, der Gefäßdichte und Tumorhypoxie
(2013-03-06)Objective. To characterize a murine renal cell carcinoma model considering hypoxia inducible tumor necrosis, macrophage infiltration as well as expression and activity level of iNOS. Methods. In vitro cultivated RENCA-cells ... -
Charakterisierung von Patienten mit Typ-1-Diabetes, die bis 2002/2003 mit täglich zwei Injektionen von Depot-Insulin Hoechst CR oder CS behandelt wurden
(2010-11-11)Introduction: Intensified conventional insulin therapy (ICT) substituting basal insulin and meal-induced insulin separately today is the standard treatment of Type 1 diabetes. However, some ... -
Chromosomale Veränderungen in Hirnmetastasen vom Lungenkrebs
(2012-11-26)Objective: To detect chromosomal aberrations that distinguish brain metastases from primary tumors in lung cancer, and that thus characterize a metastatic genotype. Methods: Using comparative genomic hybridization (CGH), ... -
Chronic hepatitis C: Liver disease manifestations with regard to respective innate immunity receptors gene polymorphisms
(2011-06-22)Hepatitis C virus (HCV) infection affects an estimated 3% of the world s population. Phenotypes of liver disease due to chronic HCV infection show a wide range of variations from one patient ... -
Darstellung der Ziele und Probleme von Patienten mit Generalisierter Angststörung
(2010-11-17)The text analysis with PATH (Problems and aims in therapy); (Staats et al. 1996; Staats et al. 2002) and mastery-awareness scale (Staats 2009) provides a multidimensional view on the ... -
Diagnostische Nachweisverfahren für Helicobacter pylori im Vergleich: Prospektive Untersuchung bei 132 Patienten der Universitätsmedizin Göttingen
(2012-11-19)In the present study the results of three possible test methods (rapid urease test, histology and 13C-urea breath test) for the detection of Helicobacter pylori (H. pylori) -infection are compared. The study is based on ...