Dokumente Human- und Zahnmedizin nach Gutachter "Zeisberg, Michael Prof. Dr."
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Charakterisierung von Ratten-Myofibroblasten des Gastrointestinaltrakts und der Leber unter Berücksichtigung mikroskopischer und molekularbiologischer Aspekte
(2013-04-30)Myofibroblasts (MF) are connective tissue cells with properties of smooth muscle cells and fibroblasts. In contrast to normal fibroblasts they express alpha smooth muscle actin (α-SMA) and Thy-1. MF have influence on the ... -
Epigenetische Therapie mit niedrig dosiertem Hydralazin verhindert die Progression vom akuten ins chronische Nierenversagen im Mausmodell
(2019-10-22)Acute kidney injury (AKI) and progressive chronic kidney disease (CKD) are intrinsically tied syndromes. In this regard, the acutely injured kidney often does not achieve its full regenerative capacity and AKI directly ... -
Galectin-3 bei Patienten mit Herzinsuffizienz mit erhaltener Ejektionsfraktion (HFpEF) - Klinische Assoziationen, Einfluss einer Aldosteron-Rezeptor-Blockade und prognostische Bedeutung - Ergebnisse der Aldo-DHF- Studie
(2015-01-29)Half of patients with heart failure suffer from heart failure with preserved ejection fraction and cardiac fibrosis is believed to be a major pathophysiological component in this condition. Galectin-3 is a marker of ... -
In-vitro- und In-vivo-Untersuchungen zum Gemcitabinmetabolismus von Makrophagen im Duktalen Adenokarzinom des Pankreas
(2022-09-26)Despite great scientific and clinical efforts, pancreatic cancer still has a fatal prognosis. In addition to the usually late diagnosis, this is mainly due to the tumour's resistance to chemotherapy. Gemcitabine and ... -
Molekulare Mechanismen der antiproliferativen und antifibrotischen Wirkung von Mycophenolsäure in vitro
(2018-01-02)The aim of this study was to elucidate functional and molecular effects of mycophenolic acid (MPA) on non-lymphatic, kidney epithelial cells treated with transforming growth factor (TGF). MPA effects were studied using HK2 ... -
Die Rolle der Bone-Morphogenetic-Proteine (BMP) -2 und -5 in der adulten humanen Niere und bei der hypertensiven Nephrosklerose
(2015-04-15)Bone Morphogentic Proteins (BMP) have extensive functions in the embryogenesis and organogenesis as well as in tissue regeneration of the adult organism. BMP-7 possesses protective and regenerative capabilities in the ... -
The role of SFRP5 in cardiomyocyte function
(2022-06-17)Heart failure is one of the most common cause of death in Germany. The current treatment options are known to decelerate disease progression, but it cannot be halted or reversed. To date, the underlying molecular mechanisms ... -
The role of the ROBO 3 signaling pathway in pancreatic cancer plasticity
(2022-09-06)Pancreatic ductal adenocarcinoma remains one of the most aggressive cancers with a 5-year survival rate below 10 %. Particularly, the clinical outcome of metastatic pancreatic cancer is extremely poor with a dismal 5-year ... -
Eine Untersuchung der Bedeutung des Apoptose-induzierenden Faktors am podozytären Zelltod
(2022-06-17)In this work, the involvement of apoptosis-inducing factor (AIF) in podocyte cell death was investigated in vitro using an established podocyte cell line. For this purpose, a model was used in which the three different ...