Browsing Human- und Zahnmedizin by Referee "Zerr, Inga Prof. Dr."
Now showing items 1-20 of 39
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14-3-3-Isoformen im Liquor cerebrospinalis bei Patienten mit verschiedenen molekularen Subtypen der sporadischen Creutzfeldt-Jakob-Krankheit
(2012-05-29)With an incidence of 1-2/1 million inhabitants sporadic Creutzfeldt-Jakob disease belongs to the rare transmissible spongiform encephalopathies caused by prions leading to spongiform degeneration of the brain and consecutively ... -
Analyse der Beschwerden von Patienten mit iatrogenem Hypoparathyreoidismus
(2013-03-28)Introduction Persistent postsurgical iatrogenic hypoparathyroidism is a significant problem after thyroid surgery for 0.5 to 4 % of patients. Despite adequate therapy with calcium and vitamin D well-being is not easily ... -
Analyse der Diagnosekriterien der Creutzfeldt-Jakob-Erkrankung in Deutschland
(2021-11-29)The Creutzfeldt-Jakob disease (CJD) is the most common prion disease. With an incident of 1.5 cases per 1,000,0000 inhabitants in Germany around 120 people (97% of all prion disease cases) are diagnosed with this disease ... -
Die Auswirkungen der zahnärztlichen Behandlung in Intubationsnarkose auf die mundgesundheitsbezogene Lebensqualität von Patienten mit kognitiver Einschränkung
(2020-03-16)OBJECTIVES: This study aimed to assess self- and proxy-rated changes in the oral health-related quality of life (OHRQoL) in adult patients with intellectual disabilities after dental treatment in general anesthesia. ... -
Auswirkungen kardiovaskulärer Risikofaktoren sowie verschiedener Vor- und Begleiterkrankungen auf den Verlauf der Alzheimer-Demenz
(2021-06-22)Alzheimer’s disease is the most common form of dementias. Among patients with Alzheimer’s disease different rates of progression have been observed, not knowing which risk factors could lead to faster cognitive decline. ... -
Die Bedeutung des p75-Neurotrophinrezeptors während der De- und Remyelinisierung im Cuprizon- Modell der Multiplen Sklerose
(2013-05-30)Multiple sclerosis (MS), the most frequent central nervous system (CNS) autoimmune disease is characterized by multiple focal demyelinated lesions. Partial remyelination of these lesions is frequently observed and considered ... -
Die Bedeutung sensibler und autonomer Ganglien in der Pathogenese der sporadischen Creutzfeldt-Jakob-Erkrankung unter Berücksichtigung des PrPsc-Typs
(2022-02-17)Abstract Background: In sporadic Creutzfeldt-Jakob disease (sCJD), the pathological changes appear to be restricted to the central nervous system. Only involvement of the trigeminal ganglion is widely accepted. Objective: ... -
Biomarker in der Diagnostik und Differentialdiagnostik der vaskulären Demenz bei zerebraler Mikroangiopathie
(2019-06-27)AIMS AND BAKCGROUND: Besides Alzheimer’s disease (AD), Vascular dementia (VD) caused by cerebral small vessel disease (CSVD) is one of the most common causes of dementia but differential diagnosis, especially the ... -
Charakterisierung mikrostruktureller Gewebeveränderungen bei der sporadischen Creutzfeldt-Jakob-Krankheit durch Korrelation von Diffusions- und Magnetisierungstransfer-Bildgebung
(2015-07-03)Novel contrasts in magnetic resonance imaging (MRI), such as diffusion-weighting (DW) or magnetization transfer (MT), are increasingly being used in clinical diagnostics. In DW-MRI, the contrast is caused by different ... -
Charakterisierung von Prädiktoren rapid-progressiver Verläufe des M. Alzheimer
(2016-07-12)Alzheimer´s Disease (AD) is a neurodegenerative disorder, whose causes still have to be elucidated. The courses of the disease are heterogen, and rapid progresses were discribed. The data about risk factors and predictors ... -
cMRT-Auffälligkeiten und Symptomatik bei CJK-Patienten - Gibt es eine Korrelation zwischen cMRT-Veränderungen und der klinischen Symptomatik
(2018-05-07)Already early in the history of CJD research, even before the detection of CJD subtypes on the basis polymorphism of codon 129 of the prion protein gene and the different types of pathological prion protein (type 1 and ... -
Diagnostische Liquorparameter der sporadischen Creutzfeldt-Jakob-Erkrankung und häufiger Differentialdiagnosen
(2013-06-28)diagnostic CSF-parameter in sporadic CJD and and common differential diagnoses -
Doxycyclin bei der sporadischen Creutzfeldt-Jakob-Krankheit
(2011-04-04)Sporadic Creutzfeldt-Jakob-Disease (CJD) is a rare neurodegenerative disorder that belongs to the group of prion diseases. The central pathological event in CJD is discussed to be the ... -
Einfluss der Überexpression des zellulären Prionproteins auf ischämisch induzierte neuronale Schädigung in vivo
(2010-12-02)The purpose of this study was to elucidate the role of PrPC overexpression in ischemic brain injury in vivo. PrPC overexpressing (TG35) and wild type (WT) mice were subjected to a 90-minute ... -
Der Einfluss des Apo-E4-Allels auf Liquorparameter und MRT-Veränderungen bei sporadischer Creutzfeldt-Jakob-Krankheit und deren Abhängigkeit von der Familienanamnese
(2017-12-12)Different studies have shown that the Apolipoprotein E4 (ApoE4) genotype appears to be associated with different forms of dementia. As a result, the ApoE4 allele constitutes a risk factor for the occurrence of Alzheimer’s ... -
Einfluss des zellulären Prion-Proteins auf die LDH-Expression unter oxidativen Stressbedingungen
(2015-11-09)Although a physiological function of the cellular prion protein (PrPc) is still not fully clarified, a PrPc-mediated neuroprotection against hypoxic/ischemic insult is intriguing. After ischemic stroke prion protein ... -
Einfluss von prä-analytischen Entnahme- und Lagerungsbedingungen auf die Stabilität und Konzentration von Amyloid-ß-Peptiden in Blut
(2022-06-29)In an increasingly aging population, age-related diseases such as dementia play a central role. Expecting an increase of the number of patients suffering from dementia worldwide, dementia-related research is becoming more ... -
Entwicklung eines PrPc-Detektions-Assays zur Analyse der Fragestellung, welchen Einfluss PRNP-Mutationen oder Genpolymorphismen in CJK-Patienten auf die PrPc-Expression haben
(2019-09-19)Prion diseases are a group of rare neurodegenerative disorders which are characterised by the conversion of cellular prion protein (PrPc) to pathological prion protein (PrPsc). Early in vivo discrimination of patients with ... -
Erstsymptom, Erstdiagnose und ärztlicher Erstkontakt bei Patienten mit sporadischer Creutzfeldt-Jakob-Krankheit in Deutschland
(2014-02-10)Background: Sporadic Creutzfeldt-Jakob disease (sCJD) is a rare, neurodegenerative disorder. To date, only few studies exist about the initial stadium of this disease. The aim of this study was to describe a maximum of two ... -
Ethische Implikationen der Prädiktion und Früherkennung einer Late-onset-Demenz
(2021-06-24)The focus on diagnosing dementia as early as possible has entered clinical practice, often supported by the use of an increasing number of available biomarkers. New diagnostics in this topic area are the subject of intense ...