Dokumente Human- und Zahnmedizin nach Gutachter "Zimmermann, Wolfram-Hubertus Prof. Dr."
Anzeige 1-11 von 11
-
Einfluss des α1(I)-Kollagens auf die Aktionspotentiale von frühen aus embryonalen Stammzellen differenzierten Kardiomyozyten
(2011-07-04)Type-I collagen is the main component of the cardiac extracellular matrix (ECM). Knockout (KO) of α1(I)-collagen is embryonically lethal. In-vitro-differentiation of cardiomyocytes from ... -
Establishment of a novel technique to study G protein-coupled receptor activation
(2011-08-17)G protein-coupled receptors (GPCRs) constitute the largest receptor family in mammals and represent important drug targets. Signaling through GPCRs mediates physiological effects that are ... -
Expression of gemcitabine metabolizing enzymes in different pancreatic cancer model systems
(2023-03-23)Pancreatic cancer still exhibits a dismal five-year overall survival rate of 9 % and is foreseen to even increase in incidence and mortality rates in the future. This is due to unspecific symptoms leading to late diagnosis, ... -
Die Hemmung der PI3K verstärkt die Kontraktilität in alpha1-adrenerg stimuliertem Myokard
(2010-11-18)Recent studies have demonstrated that phosphoinositide 3-kinases (PI3Ks) play a fundamental role in regulating myocardial contractility. However, even though a1-adrenergic receptor stimulation ... -
Humane Immunglobuline als Therapie im Mausmodell der Muskeldystrophie Duchenne
(2021-10-08)Duchenne muscular dystrophy (DMD) is the most common myopathy in childhood caused by mutations in the dystrophin gene, which results in absence or faulty production of dystrophin. Dystrophin is a subsarcolemmal structure ... -
Intrakoronare Applikation von autologen adulten Stammzellen aus dem Knochenmark: Erste Erfahrungen mit einem Infarktmodell beim Schwein
(2012-01-30)Myocardial infarction is a common consequence of heart muscle damage and remains a major cause of morbidity and mortality worldwide. Bone marrow-derived cells may contribute to the healing ... -
Der positiv inotrope Effekt von Insulin am menschlichen Myokard
(2016-06-09)Insulin has been shown to exert positive inotropic effects in several in vitro and in vivo models, but signal transduction and substrate dependency remain unclear. We examined inotropic responses and signal transduction ... -
Regulation des CREB-Koaktivators TORC durch β-adrenerge Signale in isolierten neonatalen Rattenkardiomyozyten
(2018-03-22)TORC (transducers of regulated CREB) describes a family of transcriptional cofactors, which regulates the activation of several transcription factors in dependence on cAMP. TORC is dephosphorylated and thus activated by ... -
Über die Auswirkung mechanische Last auf die Entwicklung von künstlichem Herzgewebe
(2014-11-28)The production of EHM with undifferentiated murine embryonic stem cells was improved and stabilized by multiple factors (Matrigel-free culture, supplementation of ascorbic acid, culture conditions). Cardiogenesis of ... -
Über die Differenzierung und Charakterisierung von Kardiomyozyten aus induzierten pluripotenten Stammzellen aus Rhesusmakaken in 2D- und 3D-Kulturen
(2021-11-03)Introduction: Cardiovascular diseases play a leading role in the western industrial nations in terms of mortality, morbidity and economic costs. At the same time, the heart transplant is the only causal therapy for heart ... -
Über die Herstellung von humanem Makro-Herzgewebe zur Therapie der Herzinsuffizienz
(2022-10-27)The prognosis of chronic heart failure remains unfavourable despite optimal therapy. Cardiac tissue engineering is seen as a promising approach to cardiac heart repair. The aim of this work was to investigate whether human ...