Human- und Zahnmedizin: Recent submissions
Now showing items 21-40 of 2768
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Interventioneller Pulmonalklappenersatz bei Patienten mit angeborenem Herzfehler und Pulmonalklappenvitium - eine MRT-Studie
(2023-08-09)Patients with corrected congenital heart defects now survive into adulthood thanks to modern surgical and interventional procedures. Due to these medical advancements, the number of adults with congenital heart defects now ... -
Die ethische Problematik von Scheinoperationen in der medizinischen Forschung
(2023-08-08)The publication was about to analyze the ethical problems arrising from sham surgerys. There have been some examples in liturature that show that sham surgeries or sham treatment have been performed in several studies. The ... -
Die Wirkung der selektiven Lipoxygenaseinhibitoren Baicalein und Zileuton auf die Knochenheilung im ovariektomierten Rattenmodell
(2023-08-08)Osteoporosis is the most common bone dysfunction worldwide. Decreased bone mass, destruction of bone tissue microarchitecture, and reduced bone strength characterize the disease. Particularly affected are postmenopausal ... -
Einführung eines klinischen Arbeitsplatzsystems am Beispiel der Klinik für Unfallchirurgie, Orthopädie und plastische Chirurgie
(2023-08-07)The main goal of the study is to analyze the legal requirements of the documentation of medical files in Germany. The methodology was firstly based on a literature review. Secondly, an analysis concerning the completeness ... -
Einfluss der RNA-Demethylase FTO auf die Endothelin-1-induzierte Hypertrophie im hiPSC-Kardiomyozytenmodell
(2023-08-04)Heart failure is a common disease with increasing prevalence. The disease significantly affects quality of life, and mortality and morbidity are high. Current therapies cannot stop the progression of the disease. Therefore, ... -
From the morphological to the integrated diagnosis of diffuse gliomas – a retrospective study
(2023-08-03)From the first classification of brain tumors by Rudolf Virchow in 1863 to our most recent WHO 2016 Classification, more than 150 years have passed. Within that time period, our understanding and scientific progress has ... -
Vorbereitende Studien zu Methoden der Wachstumslenkung am Schafsmodell
(2023-08-03)In the present work, investigations were carried out within the framework of the BMBF project "Externally steerable plate osteosynthesis system for children (KiD Plate)" (No.13GW0302B). The investigations concerned the ... -
Chirurgische Therapie des (lokal) fortgeschrittenen Adenokarzinoms im oberen Rektum – erste Ergebnisse aus der multizentrischen GAST-05-Phase IIb-Studie
(2023-08-01)The prospective, randomized, multicenter GAST-05 phase-IIb study (ISRCTN 35198481), funded by the German research Foundation, was designed to clarify whether partial mesorectal excision (PME, with a distal cancer-free ... -
In vitro und in vivo Charakterisierung von KAN0438757 als Inhibitor des glykolytischen Enzyms PFKFB3 im kolorektalen Karzinom
(2023-08-01)Background: Colorectal cancer is the third most common cancer and the second leading cause of cancer-associated deaths worldwide. Despite early detection screening methods, approximately 25% of patients already have ... -
Sechs versus zwölf Monate einer Clopidogrel-Therapie nach Drug-Eluting-Stentimplantation bei Patienten mit akutem Koronarsyndrom: Eine Subgruppenanalyse der ISAR-SAFE-Studie
(2023-07-31)The use of a dual antiplatelet therapy after coronary stenting to prevent a stent thrombosis is undisputable. Because of the higher bleeding risk, DAPT should only be used as long as lowering the ischemic complications ... -
Einfluss der Expression von Signaltransduktion-, Stammzell- und Zellzyklus-assoziierten Genen auf das Gesamtüberleben von pädiatrischen Glioblastompatienten
(2023-07-31)The Glioblastoma multiforme, as a highly malignant brain tumor, is associated with a very unfavorable prognosis. The median survival time after diagnosis is reported to be nine months to two years, with a 5-year survival ... -
Psychische und somatische Aspekte der Lebensqualität bei Patienten mit Vorhofflimmern - eine Gegenüberstellung von Patienten mit Sinusrhythmus, paroxysmalem und persistierendem/permanentem Vorhofflimmern
(2023-07-28)It is an empirically well established fact that health-related QoL is reduced in AF patients compared with patients with sinus rhythm. However, less well studied is the question whether the different forms of AF (paroxysmal, ... -
Dreifarbige STED-Nanoskopie von Calcium-Freisetzungseinheiten in humanem linksventrikulären Gewebe verschiedener Subtypen hochgradiger Aortenklappenstenose
(2023-07-24)Confocal microscopy and STED nanoscopy of left ventricular myocardial biopsies from patients with severe aortic valve stenosis were used to investigate mechanisms of dysfunctional cardiac remodeling at the cellular and ... -
Analyse des Einflusses virtuell geplanter Unterkieferrekonstruktionen auf die postoperative Rekonstruktionsgenauigkeit und die gesundheitsbezogene Lebensqualität bei Patienten mit ausgedehntem oralen Plattenepithelkarzinom
(2023-07-24)Extensive oral squamous cell carcinoma (OSCC) is associated with functional loss in stomatology (chewing, swallowing, speaking), esthetic limitations, and an associated reduced health-related quality of life (HRQOL). The ... -
Langzeitverlauf von Erwachsenen mit angeborenem Herzfehler – Morbidität und Mortalität im Fokus – eine 15-jährige Beobachtungsstudie
(2023-07-24)Background The population of adults with congenital heart disease (ACHD) is growing steadily. Data on the morbidity and mortality of ACHD are limited. In this longitudinal observational study, a group of ACHD with ... -
Charakterisierung und Bedeutung extrazellulärer Vesikel im Blut von Patienten mit soliden Tumoren
(2023-07-18)The goal of the study was to analyse tumour-associated extracellular vesicles in the blood of patients with solid tumour diseases and their connection with the clinical progress of the diseases. The vesicles of 330 ... -
Regulation and therapeutic targeting of MTHFD2 and EZH2 in KRAS mutated human pulmonary adenocarcinoma
(2023-07-17)With nearly 40 %, pulmonary adenocarcinomas are the main subgroup of non-small cell lung cancers. Activating KRAS mutations occur in about 30 % of pulmonary adenocarcinoma cases and the discovery of the G12C KRAS ... -
Postprozeduraler Blutdruck nach kathetergestütztem Aortenklappenersatz (TAVI) als prognostischer Parameter für das Ein-Jahres-Überleben
(2023-07-17)Background Arterial hypertension is a common comorbidity in patients with aortic stenosis. Regarding blood pressure targets after transcatheter aortic valve replacement (TAVR) prior studies show conflicting results. As ... -
Konstruktion eines vaskularisierten 3D-Zellkultursystems zur Bildung künstlicher Knochenkonstrukte und Untersuchung des Einflusses von Kollagen Typ I auf die osteogene Differenzierung von humanen mesenchymalen Stammzellen
(2023-07-17)Osteogenesis is a complex process of differentiation where osteogenic stem cells interact with vessels, cartilage cells, others tissue types and extracellular matrix. This process is also affected by nutritive, structural ... -
Untersuchung der mechanischen Dyssynchronie bei Patienten mit Ebstein-Anomalie
(2023-07-13)Background: Disease progression and heart failure development in Ebstein’s Anomaly (EA) of the tricuspid valve is characterized by both right and left ventricular (LV) deterioration. The mechanisms underlying LV dysfunction ...