Human- und Zahnmedizin
Recent Submissions
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Wirbelsäulenmetastasen – Studie zur Inzidenz neurologischer Defizite mit und ohne vorbekannten Primärtumor
(2023-05-31)Spinal metastases are present in up to 10% of patients with malignancies. In patients who present with metastases in the spine, about one fifth have not previously had a known primary tumour. We took these two elements as ... -
Lipocalin 2 als liquor und plasmabasierter Biomarker bei vaskulärer Enzephalopathie: Assoziationen mit klinischen Merkmalen und verschiedenen Formen der vaskulären Demenz
(2023-05-30)Diagnosing vascular dementia can be a significant challenge due to numerous differential diagnoses and overlapping clinical features. To supplement current neuropsychological and imaging diagnostic tools with an objective ... -
Untersuchungen zur Frage der bilateral asymmetrischen Morphologie des adulten Zebrafischherzens
(2023-05-30)Specification of the right-left body axis plays an important role in the development of vertebrate hearts. The heart is the first organ to acquire a bilaterally asymmetric shape during the embryonic period of development. ... -
Klinische und polysomnografische Charakteristika von Patienten mit Restless-Legs-Syndrom unter Augmentation
(2023-05-30)Restless legs syndrome (RLS), as a circadian movement disorder, can have a high impact on the quality of sleep and everyday life. For RLS-treatment multiple substances including dopamine agonists are recommended in the ... -
Häufigkeit und prognostische Auswirkungen einer rechtsventrikulären Beteiligung am akuten Myokardinfarkt
(2023-05-26)In the western world, acute myocardial infarction and its following injuries are among the most common causes of death, despite falling incidence. Medicine now offers a variety of modern treatment options, including drug ... -
Postoperatives Vorhofflimmern – eine klinische und experimentelle Risikoanalyse
(2023-05-24)Postoperative atrial fibrillation (poAF) is one of the most common complications after cardiac surgery and is associated with increased mortality and morbidity for the patients affected. Since the interplay of clinical and ... -
Die Rolle von ARID1A in Pankreas- und kolorektalem Karzinom
(2023-05-23)Overall, ARID1A showed a strongly context-dependent function in this study (Sun et al. 2017). In particular, in pancreatic tumors, the tumor suppressive function of ARID1A could be partially confirmed in terms of growth ... -
Analysis of the results of traumatic vertebral fractures in the thoracic and lumbar region classified as A3-fractures according to Magerl, supplied by combination of percutaneous posterior transpedicular osteosynthesis and balloon kyphoplasty
(2023-05-22)Kyphoplasty and osteosynthesis is very safe in the treatment of vertebral body fractures. Our study analysed the results of 48 patients with acute vertebral body fractures of lumbar or thoracic spine classified as A3 ... -
Klinische Performance von CAD/CAM-gefertigten Keramik-Teilrestaurationen – ein Vergleich zwischen Studierenden und Zahnärzten
(2023-05-17)The manufacturing process of CAD/CAM ceramic restorations is considered to be complex and technique-sensitive. It has already been shown for various treatment steps of the CAD/CAM workflow that their implementation depends, ... -
Analysis of Expression of RNA Helicases and Cofactors in Human Tissues and Cancer
(2023-05-11)RNA helicases are ubiquitously expressed enzymes that function as key regulators of many different aspects of gene expression. They use their nucleoside triphosphate-dependent activity to drive the remodeling of various ... -
Proteomische Analyse der Nephrotoxizität im Falle der Cyclosporin A und Tacrolimus Therapie
(2023-05-03)Immunosuppressants have made organ transplantation possible as a therapeutic intervention. One of the first and still most important groups of drugs among immunosuppressants are the calcineurin inhibitors, including ... -
Direct optogenetic stimulation of smooth muscle cells to control gastric contractility
(2023-05-02)Rationale: Antral peristalsis is responsible for gastric emptying. Its failure is called gastroparesis and often caused by dysfunction of enteric neurons and interstitial cells of Cajal (ICC). Current treatment options, ... -
Analyse der Versorgungssituation erwachsener Patienten mit Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) in der Klinik für Psychiatrie und Psychotherapie der Universitätsmedizin Göttingen
(2023-04-28)The aim of this retrospective cohort study was to describe disorder-specific sociodemographic and clinical characteristics of the study population, as well as the care situation of adult ADHD patients in the specialized ... -
SUMOylierung in Nervenzellen und deren Regulation durch Sauerstoff und Glukose
(2023-04-27)Small ubiquitin-like modifiers (SUMO) are post-translational modifications (PTM) which, similar to Ubiquitin, are conjugated to specific target proteins. The conjugation is based on an energy-dependent enzymatic cascade, ... -
Wirkung der Ganzkörperkältetherapie auf psychologische und biologische Parameter – Implikationen für die Therapie bestimmter stressassoziierter psychischer Erkrankungen
(2023-04-27)Whole-body cryotherapy is a short-term physical therapy in which subjects stay in a -110 °C cold chamber for a maximum of three minutes. The purpose of this study was to investigate the effects of whole-body cryotherapy ... -
The Effects of Conventional Chemotherapeutics on the Activation of Type I Interferons (IFN-α/β) in Hepatic Cancer Cells in vitro: The Significance of Endogenous Type III Interferons (IFN-λ)
(2023-04-24)HCC is characterized by limited therapy options, poor response rates to systemic chemotherapy, and high lethality. Preclinical cancer models have revealed the efficacy of genotoxic drugs to rely on the release of type I ... -
Evaluation des Immunophilins FKBP51 als therapeutisches Ziel in der Therapie der Osteoarthrose
(2023-04-21)Osteoarthritis (OA) is a degenerative disease leading to a destruction of the articular cartilage and the surrounding tissues of the affected joints. In the late stages it cumulates in a complete loss of joint function. ... -
Evaluation der Lebensqualität von Patienten mit Antiresorptiva-assoziierten Kiefernekrosen bei chirurgischen Therapiemaßnahmen
(2023-04-20)Medication-related osteonecrosis of the jaw (MRONJ) is a disease for which both the cause and the impact on the quality of life of affected patients are poorly understood. The aim of this study was to investigate the quality ... -
Risikofaktoren und Therapie von Antiresorptiva-assoziierten Kiefernekrosen, eine retrospektive Analyse an der Universitätsmedizin Göttingen
(2023-04-20)Antiresorptives (bisphosphonates and denosumab) are nowadays an integral part of the therapy and prophylaxis of osteoporosis and osseous metastasised bone tumours. A feared side effect of these drugs is antiresorptive-associated ... -
Die axonale Schädigung bei der Multiplen Sklerose: Korrelation von Neurofilament Leichtketten mit histologischen Markern der Axonschädigung und der Klinik
(2023-04-18)Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease associated with axonal injury, and neurofilament light chains in serum (sNfL) are considered a biomarker for this damage. We aimed to investigate the ...