Human- und Zahnmedizin
Recent Submissions
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Häufigkeit und prognostische Auswirkungen einer rechtsventrikulären Beteiligung am akuten Myokardinfarkt
(2023-05-26)In the western world, acute myocardial infarction and its following injuries are among the most common causes of death, despite falling incidence. Medicine now offers a variety of modern treatment options, including drug ... -
Postoperatives Vorhofflimmern – eine klinische und experimentelle Risikoanalyse
(2023-05-24)Postoperative atrial fibrillation (poAF) is one of the most common complications after cardiac surgery and is associated with increased mortality and morbidity for the patients affected. Since the interplay of clinical and ... -
Die Rolle von ARID1A in Pankreas- und kolorektalem Karzinom
(2023-05-23)Overall, ARID1A showed a strongly context-dependent function in this study (Sun et al. 2017). In particular, in pancreatic tumors, the tumor suppressive function of ARID1A could be partially confirmed in terms of growth ... -
Analysis of the results of traumatic vertebral fractures in the thoracic and lumbar region classified as A3-fractures according to Magerl, supplied by combination of percutaneous posterior transpedicular osteosynthesis and balloon kyphoplasty
(2023-05-22)Kyphoplasty and osteosynthesis is very safe in the treatment of vertebral body fractures. Our study analysed the results of 48 patients with acute vertebral body fractures of lumbar or thoracic spine classified as A3 ... -
Klinische Performance von CAD/CAM-gefertigten Keramik-Teilrestaurationen – ein Vergleich zwischen Studierenden und Zahnärzten
(2023-05-17)The manufacturing process of CAD/CAM ceramic restorations is considered to be complex and technique-sensitive. It has already been shown for various treatment steps of the CAD/CAM workflow that their implementation depends, ... -
Analysis of Expression of RNA Helicases and Cofactors in Human Tissues and Cancer
(2023-05-11)RNA helicases are ubiquitously expressed enzymes that function as key regulators of many different aspects of gene expression. They use their nucleoside triphosphate-dependent activity to drive the remodeling of various ... -
Proteomische Analyse der Nephrotoxizität im Falle der Cyclosporin A und Tacrolimus Therapie
(2023-05-03)Immunosuppressants have made organ transplantation possible as a therapeutic intervention. One of the first and still most important groups of drugs among immunosuppressants are the calcineurin inhibitors, including ... -
Direct optogenetic stimulation of smooth muscle cells to control gastric contractility
(2023-05-02)Rationale: Antral peristalsis is responsible for gastric emptying. Its failure is called gastroparesis and often caused by dysfunction of enteric neurons and interstitial cells of Cajal (ICC). Current treatment options, ... -
Analyse der Versorgungssituation erwachsener Patienten mit Aufmerksamkeitsdefizit-/Hyperaktivitätsstörung (ADHS) in der Klinik für Psychiatrie und Psychotherapie der Universitätsmedizin Göttingen
(2023-04-28)The aim of this retrospective cohort study was to describe disorder-specific sociodemographic and clinical characteristics of the study population, as well as the care situation of adult ADHD patients in the specialized ... -
SUMOylierung in Nervenzellen und deren Regulation durch Sauerstoff und Glukose
(2023-04-27)Small ubiquitin-like modifiers (SUMO) are post-translational modifications (PTM) which, similar to Ubiquitin, are conjugated to specific target proteins. The conjugation is based on an energy-dependent enzymatic cascade, ... -
Wirkung der Ganzkörperkältetherapie auf psychologische und biologische Parameter – Implikationen für die Therapie bestimmter stressassoziierter psychischer Erkrankungen
(2023-04-27)Whole-body cryotherapy is a short-term physical therapy in which subjects stay in a -110 °C cold chamber for a maximum of three minutes. The purpose of this study was to investigate the effects of whole-body cryotherapy ... -
The Effects of Conventional Chemotherapeutics on the Activation of Type I Interferons (IFN-α/β) in Hepatic Cancer Cells in vitro: The Significance of Endogenous Type III Interferons (IFN-λ)
(2023-04-24)HCC is characterized by limited therapy options, poor response rates to systemic chemotherapy, and high lethality. Preclinical cancer models have revealed the efficacy of genotoxic drugs to rely on the release of type I ... -
Evaluation des Immunophilins FKBP51 als therapeutisches Ziel in der Therapie der Osteoarthrose
(2023-04-21)Osteoarthritis (OA) is a degenerative disease leading to a destruction of the articular cartilage and the surrounding tissues of the affected joints. In the late stages it cumulates in a complete loss of joint function. ... -
Evaluation der Lebensqualität von Patienten mit Antiresorptiva-assoziierten Kiefernekrosen bei chirurgischen Therapiemaßnahmen
(2023-04-20)Medication-related osteonecrosis of the jaw (MRONJ) is a disease for which both the cause and the impact on the quality of life of affected patients are poorly understood. The aim of this study was to investigate the quality ... -
Risikofaktoren und Therapie von Antiresorptiva-assoziierten Kiefernekrosen, eine retrospektive Analyse an der Universitätsmedizin Göttingen
(2023-04-20)Antiresorptives (bisphosphonates and denosumab) are nowadays an integral part of the therapy and prophylaxis of osteoporosis and osseous metastasised bone tumours. A feared side effect of these drugs is antiresorptive-associated ... -
Die axonale Schädigung bei der Multiplen Sklerose: Korrelation von Neurofilament Leichtketten mit histologischen Markern der Axonschädigung und der Klinik
(2023-04-18)Multiple sclerosis (MS) is a chronic inflammatory demyelinating disease associated with axonal injury, and neurofilament light chains in serum (sNfL) are considered a biomarker for this damage. We aimed to investigate the ... -
Überprüfung eines In-Line Dialysesensors auf dessen klinische Anwendbarkeit
(2023-04-18)During acute kidney injury, the homeostasis of the electrolyte and water balance cannot be maintained or can only be maintained to a limited extent. In this case, renal replacement procedures are used to eliminate urinary ... -
Wissen und Fähigkeiten des nicht ärztlichen Personals im Rettungsdienst im Umgang mit dentalen Traumata
(2023-04-18)Dental trauma is an injury to the teeth and/or their surrounding soft and hard tissues (Lam 2016; Lam et al. 2008; Bastone et al. 2000). On average, it affects about a third of the population (Moule and Cohenca 2016). The ... -
Konfokale Mikroskopie zur Detektion von Schäden an den Nervenfasern der Kornea bei chronischer inflammatorischer demyelinisierender Polyneuropathie
(2023-04-18)Chronic inflammatory demyelinating polyneuropathy (CIDP) is an autoinflammatory disease of the peripheral nerve system typically leading to weakness and sensory symptoms. Moreover, small fiber neuropathy associated with ... -
Zusammenhang der Biomarker NT-proBNP und Galectin-3 mit dem psychischen Befinden und der Lebensqualität von Patient*innen mit Herzinsuffizienz und erhaltener Ejektionsfraktion
(2023-04-17)Chronic heart failure is a complex clinical syndrome associated with high mortality, frequent hospitalizations, poor quality of life, and cost-intensive medical care. Based on ejection fraction, the clinical picture is ...