Human- und Zahnmedizin
Recent Submissions
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Effektivität von subkutan implantierten Loop-Rekordern zur differentialdiagnostischen Abklärung von Synkopen und Herzrhythmusstörungen im Kindes- und Jugendalter
(2025-12-08)This dissertation is a single-center retrospective study that examines the effectiveness of subcutaneously implanted loop recorders for the differential diagnosis of syncope and cardiac arrhythmias in children and adolescents. ... -
Der mitochondriale Calcium-Metabolismus in der Biologie des malignen Melanoms
(2025-12-08)Melanoma remains one of the deadliest skin cancers, and despite significant progress through immunotherapies and targeted treatments such as BRAF and MEK inhibitors, many patients develop therapeutic resistance. Increasing ... -
In-vitro-Untersuchungen zur Wirksamkeit von Liganden nukleärer Rezeptoren zur Behandlung der Multiplen Sulfatase-Defizienz
(2025-12-08)Multiple sulfatase deficiency (MSD) is a rare lysosomal storage disorder. It is caused by pathogenic variants in the SUMF1 gene, which encodes the formylglycine-generating enzyme (FGE). FGE is required for the posttranslational ... -
PSSD und Leptin
(2025-12-08)This pilot study investigated whether patients with post-SSRI-sexual-dysfunction (PSSD) exhibit abnormal leptin levels and sex hormone parameters. In addition, correlations between PSSD and eating disorders, obsessive-compulsive ... -
Konnektivitätsanalyse des Routine-EEGs bei idiopathisch generalisierter Epilepsie
(2025-12-03)Epilepsy is one of the most common neurological disorders and is characterized by a persistent predisposition to excessive synchronous neuronal activity leading to epileptic seizures. Idiopathic generalized epilepsy (IGE) ... -
Characterization of oxidative stress and mitochondrial dysfunction in X-linked adrenoleukodystrophy
(2025-12-02)X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder with heterogeneous clinical manifestations, ranging from asymptomatic carriers to patients with rapidly progressive cerebral disease. Reliable biomarkers for ... -
Der zusätzliche Effekt psychologischer Interventionen im Vergleich zur trainingsbasierten Rehabilitation alleine auf die Endpunkte Depressivität, Angst und Stress bei kardial erkrakten Patient*innen - eine Metaanalyse
(2025-12-02)Psychological interventions are often added to exercise-based cardiac rehabilitation (ebCR) for patients with cardiovascular disease, but it remains unclear to what extent these interventions provide additional mental ... -
DEAR Drainage extraction after rinsing
(2025-12-02)In our clinic, several cases occurred in which the greater omentum herniated through the drain site during drain removal, requiring surgical repositioning under general anesthesia. To prevent this complication, we introduced ... -
Der Einfluss einer chronischen Lärmexposition auf die Degeneration des Corti-Organs von tauben Otoferlin-Knockout-Mäusen.
(2025-12-02)This study investigated the age-related and noise-associated degeneration of the organ of Corti in otoferlin knockout mice. This knockout causes a complete loss of otoferlin expression in the organ of Corti in mice and ... -
In-vitro-Untersuchungen zur Wirkung von Apigenin als Therapeutikum für die Multiple Sulfatase Defizienz
(2025-12-02)Multiple Sulfatase Deficiency (MSD) is a rare, autosomal recessive lysosomal storage disorder caused by pathogenic variants in SUMF1, resulting in deficient activity of all cellular sulfatases. The lack of functional ... -
Trans-ECMO thermodilution to measure recirculation during veno-venous Extracorporeal Membrane Oxygenation: an experimental animal study
(2025-12-02)ARDS is a syndrome responsible for an impressive morbidity and mortality. In the most severe cases, the lung function is so compromised that the oxygenation and decarboxylation provided are simply no more compatible with ... -
Wie beeinflusst Bestrahlung der extrazellulären Matrix das Invasionsverhalten von Nierenzellkarzinomen?
(2025-12-02)Renal cell carcinoma often forms bone metastases and is often only discovered in late stages due to metastasis-associated symptoms. Affected patients suffer from pain, the survival rates are poor. Thanks to new techniques ... -
Monozentrische retrospektive Analyse zum Vorliegen eines prognostischen Markers beim Marginalzonenlymphom anhand von klinischen Daten und weiterführender Target-Sequenzierung eines lymphatischen Genpanels.
(2025-11-26)Marginal zone lymphomas are a rare entity within the group of indolent B-cell lymphoma. Prognostic markers for clinical practice are currently only available to a limited extent. This retrospective study examined a monocentric ... -
Untersuchung zum vaskulären Remodelling in venösen Bypassgefäßen nach Lagerung in verschiedenen Gefäßprotektionslösungen im Gefäßtransplantationsmodell der Ratte
(2025-11-20)After the establishment of aortocoronary bypass surgery for the treatment of advanced coronary artery disease, the great saphenous vein, together with the internal mammary artery, became the principal conduit for coronary ... -
Die Wirkung von Baicalein und Zileuton auf das Knochengewebe am ovarektomierten Rattenmodell
(2025-11-20)Osteoporosis is the most common metabolic bone disease worldwide and has gained increasing attention in research, not only due to a progressively aging population but also because of its broad impact on patients, society, ... -
Der Einfluss von kontinuierlichen Nierenersatzverfahren auf die Bestimmung des Herzzeitvolumens mittels Thermodilutions-Technik
(2025-11-20)This study examines the effects of continuous renal replacement therapy (CRRT) on cardiac output (CO) measurement using both transpulmonary and pulmonary artery thermodilution techniques. As CRRT is commonly applied ... -
Schlafstörungen und deren Erkennung bei Früh- und Neugeborenen im ersten Lebensjahr
(2025-11-19)Sleep disturbances in newborns affect the child’s development as well as the emotional wellbeing and quality of life of their parents and the entire family. To date, the causes, manifestations, and early predictors of sleep ... -
Ampicillin und Cefotaxim in der Intensivmedizin: Eine retrospektive Plasmaspiegel-Analyse
(2025-11-18)Ampicillin and cefotaxime are among the antibiotics most commonly used in critically ill patients. However, their use in this context has only been sporadically described and analyzed in the scientific literature to date. ... -
Untersuchung zur Tragedauer von Okklusionsschienen bei Patient*innen mit myofaszialen Schmerzen
(2025-11-18)This study examined the compliance of patients with myofascial pain with occlusal splint therapy using objective wear time recording. The intraoral wear time of the splints was measured over 90 days using integrated ... -
Seltene pädiatrische nicht-diffuse hochgradige Gliome: Epidemiologische und klinische Charakterisierung von anaplastischen Gangliogliomen, anaplastischen pleomorphen Xanthoastrozytomen und pilozytischen Astrozytomen mit Anaplasie
(2025-11-18)Pediatric high-grade gliomas (pHGG) are rare and aggressive central nervous system tumors in children and adolescents. Non-diffuse subtypes such as anaplastic ganglioglioma, anaplastic pleomorphic xanthoastrocytoma, and ...