Human- und Zahnmedizin
Recent Submissions
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Welche Rolle spielt SERPINE1/PAI-1 bei der Progression des Zervixkarzinoms?
(2025-12-15)Cervical cancer is the fourth most common cancer in women worldwide. To date, little is known about the G protein-coupled estrogen receptor 1 (GPER1) in cervical cancer. In our working group, Ruckriegl et al. have already ... -
Die Entwicklung und der Verlauf der REM-Schlaf-Verhaltensstörung bei Parkinson-Patienten
(2025-12-15)REM sleep behaviour disorder (RBD) is a parasomnia that occurs predominantly in neurodegenerative diseases such as Parkinson’s disease (PD). Moreover, in individuals with an established diagnosis of PD, RBD is associated ... -
Die Entwicklung des klinischen Outcomes nach Schädel-Hirn-Trauma bei Patienten über 60 Jahren – Ein Vergleich zwischen einer aktuellen Patientenkohorte und einer früheren aus den 80er Jahren
(2025-12-11)With demographic aging, the incidence of traumatic brain injury (TBI) in older adults is increasing significantly. Elderly patients exhibit distinct risk profiles, different trauma mechanisms, and increased vulnerability. ... -
Funktionelle Charakterisierung des organischen-Kationen Protonen Antiporters (H+/OC) und der Kationentransporter MATE1, MATE2-K, OCT1, OCT2, OCT3 und PMAT
(2025-12-10)Approximately 30% of all endogenous substances, as well as many drugs and other biologically relevant molecules, are organic cations. A central aim of this work was to investigate how these positively charged molecules ... -
Der Verlauf von Surrogat-Markern der Leberverfettung unter Metformin-Therapie in PCOS-Patientinnen
(2025-12-10)Polycystic ovary syndrome (PCOS) is a common condition among women of reproductive age. In addition to its core manifestations—hirsutism, fertility problems, and obesity—it is frequently associated with a range of ... -
Vergleichende Analyse interstitieller Lungenerkrankungen bei Autoimmunerkrankungen
(2025-12-10)The Antisynthetase syndrome and Systemic Sclerosis are classified as connective tissue diseases. Pulmonary involvement in these diseases, in the form of interstitial lung disease (ILD), significantly increases the mortality ... -
Identifikation von immunhistochemischen Biomarkern für die Diagnose von Pankreaskarzinomen
(2025-12-10)The distinction between pancreatic ductal adenocarcinoma (PDAC) and cholangiocarcinoma (CCA) is clinically important, as it significantly influences therapeutic decisions, including surgical and adjuvant strategies. ... -
Effektivität von subkutan implantierten Loop-Rekordern zur differentialdiagnostischen Abklärung von Synkopen und Herzrhythmusstörungen im Kindes- und Jugendalter
(2025-12-08)This dissertation is a single-center retrospective study that examines the effectiveness of subcutaneously implanted loop recorders for the differential diagnosis of syncope and cardiac arrhythmias in children and adolescents. ... -
Der mitochondriale Calcium-Metabolismus in der Biologie des malignen Melanoms
(2025-12-08)Melanoma remains one of the deadliest skin cancers, and despite significant progress through immunotherapies and targeted treatments such as BRAF and MEK inhibitors, many patients develop therapeutic resistance. Increasing ... -
In-vitro-Untersuchungen zur Wirksamkeit von Liganden nukleärer Rezeptoren zur Behandlung der Multiplen Sulfatase-Defizienz
(2025-12-08)Multiple sulfatase deficiency (MSD) is a rare lysosomal storage disorder. It is caused by pathogenic variants in the SUMF1 gene, which encodes the formylglycine-generating enzyme (FGE). FGE is required for the posttranslational ... -
PSSD und Leptin
(2025-12-08)This pilot study investigated whether patients with post-SSRI-sexual-dysfunction (PSSD) exhibit abnormal leptin levels and sex hormone parameters. In addition, correlations between PSSD and eating disorders, obsessive-compulsive ... -
Konnektivitätsanalyse des Routine-EEGs bei idiopathisch generalisierter Epilepsie
(2025-12-03)Epilepsy is one of the most common neurological disorders and is characterized by a persistent predisposition to excessive synchronous neuronal activity leading to epileptic seizures. Idiopathic generalized epilepsy (IGE) ... -
Characterization of oxidative stress and mitochondrial dysfunction in X-linked adrenoleukodystrophy
(2025-12-02)X-linked adrenoleukodystrophy (X-ALD) is a peroxisomal disorder with heterogeneous clinical manifestations, ranging from asymptomatic carriers to patients with rapidly progressive cerebral disease. Reliable biomarkers for ... -
Der zusätzliche Effekt psychologischer Interventionen im Vergleich zur trainingsbasierten Rehabilitation alleine auf die Endpunkte Depressivität, Angst und Stress bei kardial erkrakten Patient*innen - eine Metaanalyse
(2025-12-02)Psychological interventions are often added to exercise-based cardiac rehabilitation (ebCR) for patients with cardiovascular disease, but it remains unclear to what extent these interventions provide additional mental ... -
DEAR Drainage extraction after rinsing
(2025-12-02)In our clinic, several cases occurred in which the greater omentum herniated through the drain site during drain removal, requiring surgical repositioning under general anesthesia. To prevent this complication, we introduced ... -
Der Einfluss einer chronischen Lärmexposition auf die Degeneration des Corti-Organs von tauben Otoferlin-Knockout-Mäusen.
(2025-12-02)This study investigated the age-related and noise-associated degeneration of the organ of Corti in otoferlin knockout mice. This knockout causes a complete loss of otoferlin expression in the organ of Corti in mice and ... -
In-vitro-Untersuchungen zur Wirkung von Apigenin als Therapeutikum für die Multiple Sulfatase Defizienz
(2025-12-02)Multiple Sulfatase Deficiency (MSD) is a rare, autosomal recessive lysosomal storage disorder caused by pathogenic variants in SUMF1, resulting in deficient activity of all cellular sulfatases. The lack of functional ... -
Trans-ECMO thermodilution to measure recirculation during veno-venous Extracorporeal Membrane Oxygenation: an experimental animal study
(2025-12-02)ARDS is a syndrome responsible for an impressive morbidity and mortality. In the most severe cases, the lung function is so compromised that the oxygenation and decarboxylation provided are simply no more compatible with ... -
Wie beeinflusst Bestrahlung der extrazellulären Matrix das Invasionsverhalten von Nierenzellkarzinomen?
(2025-12-02)Renal cell carcinoma often forms bone metastases and is often only discovered in late stages due to metastasis-associated symptoms. Affected patients suffer from pain, the survival rates are poor. Thanks to new techniques ... -
Monozentrische retrospektive Analyse zum Vorliegen eines prognostischen Markers beim Marginalzonenlymphom anhand von klinischen Daten und weiterführender Target-Sequenzierung eines lymphatischen Genpanels.
(2025-11-26)Marginal zone lymphomas are a rare entity within the group of indolent B-cell lymphoma. Prognostic markers for clinical practice are currently only available to a limited extent. This retrospective study examined a monocentric ...