Human- und Zahnmedizin
Recent Submissions
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Patienten mit fortgeschrittenen hämatologischen Grunderkrankungen in der Spezialisierten Ambulanten Palliativversorgung (SAPV)
(2025-01-17)Patients with advanced haematological malignancies in non-curative settings suffer from complex physical symptoms and psychosocial distress, comparable to patients with solid tumour entities. Nevertheless, numerous problems ... -
Evaluation des Krankheitsverlaufs von Patienten mit Diabetes mellitus Typ 2 der Diabetesambulanz der UMG anhand laborchemischer und klinischer Parameter – eine retrospektive Analyse des Zeitraums 2014 bis 2021
(2025-01-17)The aim of this doctoral thesis was to investigate the disease progression and treatment courses of patients with type 2 diabetes at the diabetes outpatient department of University Medical Center Göttingen between the ... -
Untersuchung plasmabasierter Kompositbiomarker in der Differentialdiagnostik von Alzheimer-Demenz und Vaskulärer Demenz
(2025-01-17)Due to demographic change, dementia is not only at the center of medical research but is also becoming increasingly important in the health economic and social debate. Taking that into consideration, dementia diagnostics ... -
Persönlichkeit und Inkongruenzerleben als Determinanten des Effekts eines 6-wöchigen hochfrequenten, standardisierten Sportprogramms (SIWAS-Studie)
(2025-01-17)The therapeutic effect of exercise on mental illness has already been shown many times and for patients with various mental illnesses, especially depression (Knapen et al. 2014, Dauwan et al. 2015). However, little research ... -
Die Rolle der CHD1 Depletion im Prostatakarzinom bei der epithelial zu mesenchymalen Transition und der ossären Metastasierung
(2025-01-17)In the treatment of advanced prostate cancer with androgen deprivation, almost all patients develop castration resistance after some time. The tumor growth continues despite ongoing therapy. In these castration-resistant ... -
Molecular assembly of auditory ribbon synapses in mice
(2025-01-17)Auditory ribbon synapses are specialized structures in the inner hair cells (IHCs) that enable rapid neurotransmitter release, making them essential for precise signal transmission in the auditory system. However, insights ... -
Erhebung echokardiographischer Parameter zur Quantifizierung der Pulmonalklappeninsuffizienz und Vergleich zur Schweregradbeurteilung im MRT
(2025-01-17)Pulmonary regurgitation (PR) is a common valvular disease in patients with congenital heart defects (CHD) and contributes to morbidity and mortality in the long-term. This retrospective analysis invastigated wether ... -
Exploring the role of Cytoglobin (CYGB) in melanoma pathobiology
(2025-01-17)Skin cancer is one of the most common malignancies worldwide, with melanoma being the deadliest form. Although both targeted therapies inhibiting the MAPK pathway and immunotherapy have improved the prognosis of patients ... -
Biomechanische Untersuchungen ventraler Osteosyntheseverfahren bei Densfrakturen Anderson und D’Alonzo Typ II
(2025-01-14)The data on the use of single- or double-screw techniques for anterior osteosynthesis of type II odontoid fractures is inconclusive and contradictory. Although the double-screw technique appears to offer more rotational ... -
Untersuchung der sprechbezogenen Veränderungen der Erregbarkeit im primären Motorkortex bei Stotternden und Kontrollprobanden mittels transkranieller Magnetstimulation
(2025-01-14)Transcranial magnetic stimulation reveals a lack of reduction of intracortical inhibition of the tongue primary motor cortex in adults who stutter as compared to fluent speakers: Original neurogenic non-syndromic ... -
Analyzing Pedicle Screw Strength with Finite Element Method in Relation to Vertebral Bone Properties
(2025-01-13)Vertebral fractures are increasingly prevalent in our aging population. Conservative treatments and minimally invasive surgeries are standard, but posterior fixation systems like pedicle-screw-rod constructs face failure ... -
Der Einfluss von NOTCH-Rezeptoren auf die Radiochemotherapie-Sensitivität kolorektaler Tumorzellen
(2025-01-13)The treatment of colorectal cancer remains a challenge to this day. Despite numerous advances in therapy, the prognosis, especially in advanced or metastatic stages, remains poor. A current standard therapy for locally ... -
Serum-25-Hydroxyvitamin D als Prädiktor der Lebensqualität bei Jugendlichen mit allergischer Rhinokonjunktivitis
(2025-01-09)Summary Numerous studies have investigated associations between serum concentrations of 25-hydroxyvitamin D and parameters of health-related quality of life, erythropoiesis and cancer risk. The aim of the present post-hoc ... -
Die Rolle glyzinerger Neurone und des Asc-1 Transporters bei der Modulation der glutamatergen, NMDA-Rezeptor vermittelten synaptischen Transmission am Nucleus nervi hypoglossi
(2025-01-09)The aim of this thesis was to investigate the role and function of glycinergic neurons and the Asc-1 transporter in the modulation of glutamatergic NMDA receptor-mediated synaptic transmission in motoneurons of the hypoglossal ... -
Untersuchungen zum Einfluss von Scherspannung, Inflammation und BET-Inhibition auf humane epitheliale Zellen
(2025-01-09)Atherosclerosis is an important cause of some of the most common causes of death, cardiovascular disease. In addition to dyslipidemia, inflammation is one of the key causes of remodeling processes in the endothelium, which ... -
Copingmechanismen und -dynamiken als Prädiktoren für die Lebensqualität sowie das somatische Outcome von Proband*innen mit einer Herzinsuffizienz oder Risikofaktoren dafür
(2025-01-09)Chronic heart failure is a highly prevalent disease. For the patients affected heart failure is associated with poor prognosis and, in most cases, a reduced quality of life. Some widespread diseases are considered risk ... -
Langlebigkeit wiederbefestigter Zahnfragmente im Vergleich zu Kompositrestaurationen zur Therapie von Schmelz-Dentin-Frakturen
(2025-01-08)The adhesive reattachment of a tooth fragment is a treatment option for traumatic enamel-dentin-fractures in permanent teeth. If the fragment is not available or cannot be reattached, the fracture can be treated with a ... -
In vivo-Studie zur Flussdynamik von Hirnwasser in Kindern und Jugendlichen mit Liquorzirkulationsstörungen – erste klinische Anwendung von Echtzeit- Phasenkontrast-MRT
(2025-01-07)In recent years, the use of real-time phase-contrast MRI has led to an enormous increase in knowledge regarding the flow dynamics of cerebrospinal fluid (CSF). Decades of prevailing doctrine, which assumed a unilateral ... -
Retrospektive Studie zur Erhebung von Risiko-Scores zur frühzeitigen Prädiktion von Post-Polypektomie-Blutungen im Gastrointestinaltrakt
(2025-01-06)Post-polypectomy bleeding (PPB) is a common and clinically relevant complication following gastrointestinal polypectomy. Their severity ranges from mild to severe events. Nervertheless, accurate prediction in clinical ... -
Analyse von Klettersportler*innen
(2025-01-02)With regard to the increasing popularity of climbing, a prospective clinical study was conducted. 51 amateur climbers, who climbed at medium levels of difficulty, were statistically compared with a cohort of 49 non-climbing ...