Human- und Zahnmedizin
Recent Submissions
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Die Wirkung der Desinfektion der behandschuhten Hand auf die Händehygiene-Compliance bei infektionsgefährdenden Tätigkeiten auf einer Stammzellstation
(2025-03-20)Background: Hand hygiene compliance even before infection-prone procedures (indication 2, ‘before aseptic tasks’, according to the World Health Organization (WHO)) remains disappointing. Aim: To improve hand hygiene ... -
Evaluation der nächtlichen Asthmakontrolle bei Kindern und Jugendlichen
(2025-03-20)Asthma is the most common chronic disease in childhood and adolescence. The disease underlies a circadian rhythm with worsening of symptoms at night. The absence of nocturnal symptoms is one of the four criteria to define ... -
Sensibilisierung des triple-negativen Mammakarzinoms gegenüber Tamoxifen durch Hemmung des membranständigen Estrogenrezeptors GPER1
(2025-03-14)Breast cancer that is negative for the estrogen receptor α (ER α), the progesterone receptor and the human epidermal growth factor receptor 2 is referred to as triple-negative breast cancer (TNBC). This tumor subtype is ... -
TransValid-A-Studie zur präoperativen, 5-FU-basierten Chemo-/Radiotherapie bei Rektumkarzinomen: Machbarkeit, Durchführbarkeit und erste Ergebnisse
(2025-03-14)The single-arm, multicenter TransValid-A study (ClinTrials. gov: NCT03034473; funded by the German Research Foundation, DFG; GZ: LI 1727/3-1) examined under real-world conditions the feasibility and efficacy of 5-fluorouracil ... -
Quantifizierung spontaner Calcium-Freisetzungen in humanen atrialen Kardiomyozyten aus induzierten pluripotenten Stammzellen (iPSC)
(2025-03-13)Atrial fibrillation (AF) is a cardiac disorder characterized by disorganized electrical excitation of the atria. AF is the most common cardiac arrhythmia in clinical practice and is associated with increased cardiovascular ... -
Die Bestimmung der Dichte von Glaskörperproben, Ocriplasmin und verschiedenen Anti-VEGF-Substanzen zur Optimierung der postoperativen Lagerung nach intravitrealer Medikamentenapplikation (IVOM)
(2025-03-13)The dissertation is based on the idea of allowing the drug to migrate into the premacular area through ‘density-appropriate’ patient positioning after intravitreal drug application (IVOM) in the centre of the vitreous body. ... -
Die Rolle der Hedgehog Signalkaskade in Ependymomen
(2025-03-12)In this thesis the activity of Hedgehog (HH) signaling in ependymoma was analyzed. To this end, immunohistochemical stainings were performed on 86 paraffin sections to examine the expression of Sonic Hedgehog (SHH). The ... -
Komplikationen der transseptalen Punktion bei kinderkardiologischen Herzkatheteruntersuchungen im Vergleich zu Komplikationen der transseptalen Punktion im Rahmen von Herzkatheteruntersuchungen bei erwachsenen Patienten
(2025-03-07)Transseptal puncture (TSP) is a standard procedure to obtain access to the left heart in adults with a complication rate ranging from 0,72% to 3.6%. However, data on TSP in infants and children particularly with congenital ... -
Echtzeit-Magnetresonanztomographie zur Evaluation von Atemstörungen bei Patient*innen mit Morbus Pompe
(2025-03-07)Respiratory dysfunction is a major contributor to morbidity and mortality in patients suffering from Pompe disease. Standard diagnostic methods, which aim to evaluate diaphragm weakness, often diagnose it at a later stage ... -
Einfluss regelmäßiger stationärer Beatmungskontrollen auf den Beatmungseffekt und die Compliance bei Patienten mit nichtinvasiver Heimbeatmung
(2025-03-07)Patients with ventilatory insufficiency develop hypercapnia. This can occur acutely or be chronic. If hypercapnia is chronic, there is a metabolic compensation with increased bicarbonate (HCO3-). In cases of chronic ... -
Ethische Herausforderungen der COVID-19-Pandemie im internationalen Vergleich: Erkenntnisse aus 39 Expert*inneninterviews
(2025-03-06)Since spring 2020, the SARS-CoV-2 coronavirus has spread worldwide, causing profound medical, political, economic, cultural, and bioethical challenges in the ensuing pandemic. While the resulting conflicts initially appeared ... -
Untersuchung zur Auswirkung eines Mund-Nasen-Schutzes auf die Mundgesundheit
(2025-03-06)Abstract The aim of this single-center, randomized, exploratory and controlled cross-over observational study was to investigate the influence of cloth, medical and FFP2 masks on saliva parameters and the occurrence of ... -
Retinale Gefäßverschlüsse nach Impfung gegen SARS-CoV-2 - eine multizentrische Erhebung an deutschen Augenzentren
(2025-03-05)Background: To investigate whether vaccination against SARS-CoV-2 is associated with the onset of retinal vascular occlusive disease (RVOD). Methods: In this multicentre study, data from patients with central and branch ... -
Anwendung von Click-Chemie zur Darstellung neuronaler Proteine in X10-Expansion
(2025-03-04)X10 Expansion Microscopy is a cost-effective method that allows for high-resolution imaging by expanding samples by a factor of ten through water absorption, enabling resolution down to 20 nm with conventional fluorescence ... -
Membrantransport von Substanzen mit ZNS-Wirkungen oder Nebenwirkungen über organische Kationentransporter
(2025-02-28)In addition to simple diffusion, carrier-mediated transport represents one possibility of exchange across the blood-brain barrier. This enables selective transport across membranes and plays an essential role in the specific ... -
In-ovo-Untersuchungen zum Zellstoffwechsel des Hodgkin-Lymphoms
(2025-02-27)Excellent survival rates of patients with Hodgkin lymphoma (HL), a malignant neoplasm of the lymphatic system, may be compromised by acute and long-term toxicities, including infertility, cardiovascular damage, and secondary ... -
Einfluss von Tumormutationen auf die Sekretion extrazellulärer Vesikel
(2025-02-27)Extracellular vesicles (EVs) are small structures surrounded by a lipid bilayer, carrying specific cargo from their cell of origin to more distant cells, therefore functioning as vehicles in cell-to-cell communication. ... -
In-vitro-Charakterisierung der kardialen Elektrophysiologie beim Noonan- Syndrom und Noonan-Syndrom mit multiplen Lentiginosen anhand eines stammzell-basierten 3D-Modells
(2025-02-27)Noonan syndrome and Noonan syndrome with multiple lentigines are classified as RASopathies, resulting from mutations in the RAS/MAPK signaling pathway. Patients typically exhibit a range of symptoms, with cardiac abnormalities ... -
Adhäsionsverhalten von Multispezies-Biofilmen aus Aggregatibacter actinomycetemcomitans, Staphylococcus epidermidis und Streptococcus sanguinis auf Titanoberflächen in vitro
(2025-02-25)Objective: Biofilm-associated peri-implant diseases are a major cause of the loss of osseointegrated dental implants. The accumulation of oral biofilms is primarily influenced by the surface topography of biomaterials ... -
Die Etablierung einer neuen NGS-basierten Panelanalyse zur Identifikation der genetischen Ursachen isolierter und syndromaler Formen der Mikrophthalmie
(2025-02-25)Microphthalmia and anophthalmie are part of the spectrum of rare diseases. Microphthalmia is defined as a developmental disorder of the eye, in which the globe of the eye is more than two standard deviations below the ...