Human- und Zahnmedizin
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Characterization of urine proteome pattern changes associated with early diabetic nephropathy: a proteomic approach
(2024-04-19)Type 2 diabetes mellitus has become the most common cause of kidney failure in Europe and the United States. In Germany, 8.7 million people live with type 2 diabetes, although an estimated two million more affected people ... -
Target recognition of an RNA methyltransferase
(2024-04-18)To date more than 150 different RNA modifications have been detected in cellular RNAs and are collectively termed the epitranscriptome. RNA modifications occur at different positions within each of the four bases or the ... -
Die Entwicklung von Nanobody-funktionalisierten Goldoberflächen
(2024-04-15)Atomic force microscopy enables three-dimensional imaging of samples. The use of antibodies to improve the accuracy of microscopy is an established method. An antibody can be linked to the golden tip of an atomic force ... -
Complementary medicine treatment options for children with diffuse intrinsic pontine gliomas
(2024-04-11)Diffuse intrinsic pontine glioma is a rare but lethal brain tumor with a median survival of eleven months after diagnosis. There has been no significant improvement in survival over the past 50 and more years despite ... -
Characterization Of Pirfenidone Effects In Human Cardiac Fibroblasts
(2024-04-08)Background Cardiac fibrosis is a major problem in heart diseases, but it is still lacking an effective therapy. The drug pirfenidone has shown several anti-fibrotic effects in animal models of heart diseases and is already ... -
Analyse der ARHGAP29-abhängigen Signalisierung der Invasion von Mammakarzinomzellen
(2024-04-08)Despite expanded early detection examinations and improved treatment options, breast cancer remains the most common cause of death from cancer in women worldwide. Fundamental to the development of innovative therapies is ... -
Extending the classical histological routine through microcomputed tomography imaging and multimodal image processing
(2024-04-08)Histological analysis has proven to be the de facto gold standard for the characterization of hard and soft tissue samples at cellular resolution in both clinical routine and biomedical research. After the tissue sample ... -
Activity-dependent turnover of the Perineural Extracellular Matrix
(2024-04-05)The different molecules present in the extracellular space of the brain make-up the perineural extracellular matrix (ECM). One of the specializations of the perineural ECM, the perineural nets (PNNs), are lattice-like ... -
Die biomechanische Analyse des Kiefergelenks mit Hilfe eines neuen Echtzeit-MRT-Verfahrens
(2024-04-03)Aim: The traditional hinge axis theory of temporomandibular joint (TMJ) dynamics is increasingly being replaced by the theory of instantaneous centers of rotation (ICR). Typically, ICR determinations are based on theoretical ... -
Elimination des freien Hämoglobins an der Herz-Lungen-Maschine zur Prävention eines akuten Nierenversagens nach kardiochirurgischen Eingriffen
(2024-04-02)Acute kidney failure after cardiac surgery using the heart-lung machine (HLM) remains a serious complication with high morbidity and mortality. There are currently no valid preventive concepts that enable perioperative ... -
Prospektive Untersuchung des Schädelwachstums Frühgeborener von Geburt bis zum errechneten Geburtstermin
(2024-03-28)Using stereophotogrammetry for a longitudinal 3D analysis of the head growth of preterm born neonates from birth to term. -
Evaluation des therapeutischen Potentials von intravenös appliziertem Metallothionein-II im Schlaganfall Modell der Maus unter Thrombolyse
(2024-03-27)Stroke is the second leading cause of death worldwide. The only available drug therapy is thrombolysis using recombinant tissue-specific plasminogen activator (rtPA), which can only be used to a limited extent due to the ... -
Der Einfluss von Aβ4-42 auf die Kognition und die Anwendung von Suchstrategien im Morris Water Maze im Tg4-42-Mausmodell
(2024-03-25)The relevance of Alzheimer's dementia for our society is increasing. Soluble amyloid beta (Aβ) plays a particularly important role in the genesis of this disease. Aβ4-42 in particular, which is truncated before the fourth ... -
Rolle des G-Protein-gekoppelten Östrogenrezeptors 1 (GPER1) beim Zervixkarzinom
(2024-03-21)Cervical cancer is the fourth most common cancer in women and after the mamma carcinoma the second most common gynecological carcinoma. The G-Protein-coupled Estrogen Receptor 1 (GPER1) is an important ubiquitous receptor ... -
Epigenetische Grundlagen der (Kreuz)-Resistenz von Antiandrogenen neuer und neuster Generation
(2024-03-20)Prostate cancer grows androgene-dependent, because of which, antiandrogen therapy is used in advanced tumor stages. Most antiandrogens inhibit the androgen receptor directly, but Abiraterone inhibits androgen synthesis. ... -
Die prognostische Bedeutung von Vorhofflimmern bei Patienten mit akuter Lungenembolie
(2024-03-18)Background: Although prior studies indicate a high prevalence of atrial fibrillation (AF) in patients with pulmonary embolism (PE), the exact prevalence and prognostic impact are unknown. Methods: We aimed to investigate ... -
Individualisierung menschlicher Überreste in zwei historischen Schädelsammlungen der Universität Göttingen und ihr Beitrag zur bioanthropologischen Provenienzforschung
(2024-03-14)The University of Göttingen is in possession of two large collections of human remains: The Blumenbach Skull Collection and the Anthropological Collection. Human remains from Hawaii and Tanzania with a colonial context ... -
Korrelation der 5-Flucytosin-Resistenz in Candida albicans mit Markerpeak im MALDI-Massenspektrum durch neue Extraktionsmethode
(2024-03-06)Candida albicans is a facultative pathogenic fungus that occurs worldwide and is found in the gastrointestinal tract of the majority of people. In immunocompromised patients, however, it can lead to severe systemic infections. ... -
Auswirkung von verschiedenen Gefäßklemmen auf die Kollagenmatrix der ovinen biosynthetischen Gefäßprothese
(2024-03-04)Background: Ovine biosynthetic prostheses have established themselves in the field of vascular surgery; they can be used effectively both for septic vascular surgery – in cases where there are no autogenous bypass materials ... -
Einfluss genetischer Varianten der negativ-kostimulierenden T-Zell-Inhibitoren TIM-3 und LAG-3 auf das Outcome von Patienten mit Sepsis
(2024-03-04)Background: Each year, millions of people die from sepsis or its consequences. Sepsis is defined as a life-threatening condition based on a dysregulated immune response to an infection. Thus, investigating the complex ...