Human- und Zahnmedizin
Recent Submissions
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Investigation of RBM20-mutation based LVNC and DCM in an iPSC model: Novel insights into Ca2+ handling, affection of the atria and crosstalk between cardiomyocytes and endothelial cells
(2025-03-27)In this study, RBM20-mutation based LVNC and DCM were investigated based on an already established in-vitro platform with iPSC generated from two patients: One had LVNC and the RBM20 mutation p.R634L, the other had DCM ... -
Die Auswirkungen der langfristigen Gabe von WIN 55,212-2 auf die Neurogenese und Neuroinflammation bei Wildtyp-Mäusen
(2025-03-27)This study investigated the effects of long-term administration of WIN55,212-2, a synthetic aminoalkylindole, on healthy mouse brains in two different age groups. The impacts on neurogenesis, neuroinflammation, and CB1 ... -
Etablierung von Mutagenesemethoden zur pathophysiologischen Analyse der Signalaktivität in B-Lymphozyten
(2025-03-27)B cell receptor (BCR) signaling plays a crucial role in B cell activation, differentiation, and immune response. Dysregulation of this pathway is associated with various immunodeficiencies and B cell malignancies. This ... -
The regulation of the transcription factor TFEB in B cells via pathways of the B cell antigen receptor
(2025-03-25)The signalling pathways downstream of the BCR are vital for B cell function and previous to this work, it was shown that TFEB is a transcription factor implicated in the cellular re sponse of B cells to the stimulation ... -
Asymptomatische Diastolische Dysfunktion Klinische Prädiktoren und Langzeitverlauf
(2025-03-25)A total of 851 patients from the DIAST-CHF study were examined for their five-year outcome. The patients had at least one risk factor for the development of heart failure, but had no signs or symptoms of heart failure at ... -
Prospektive Studie zum Vergleich unterschiedlicher Strategien zur Zementierung von monolithischen Zirkonoxidkronen
(2025-03-25)Zirconia is often used for the fabrication of single crowns (SCs) and other fixed dental prostheses (FDPs) due to its mechanical properties, aesthetics, and excellent biocompatibility (Barão et al. 2010; Manicone et al. ... -
Vergleich der Wurzelkanalpräparation an echten Zähnen im Vergleich zu 3D-gedruckten Zähnen: eine Mikro-CT-Studie
(2025-03-24)Objective: The aim of this study was to evaluate the suitability of three-dimensionally printed teeth for endodontic education by comparing them with natural teeth. Methods: Using micro-computed tomography (µCT) and ... -
Der Einfluss von medizinischem Kaltplasma auf kutanes Gewebe und Wunden
(2025-03-20)In the present study, the effects of medical cold plasma on human skin were investigated. On the one hand, the focus was on the impact of medical cold plasma on measurable parameter changes, particularly the microcirculation ... -
Die Wirkung der Desinfektion der behandschuhten Hand auf die Händehygiene-Compliance bei infektionsgefährdenden Tätigkeiten auf einer Stammzellstation
(2025-03-20)Background: Hand hygiene compliance even before infection-prone procedures (indication 2, ‘before aseptic tasks’, according to the World Health Organization (WHO)) remains disappointing. Aim: To improve hand hygiene ... -
Evaluation der nächtlichen Asthmakontrolle bei Kindern und Jugendlichen
(2025-03-20)Asthma is the most common chronic disease in childhood and adolescence. The disease underlies a circadian rhythm with worsening of symptoms at night. The absence of nocturnal symptoms is one of the four criteria to define ... -
Sensibilisierung des triple-negativen Mammakarzinoms gegenüber Tamoxifen durch Hemmung des membranständigen Estrogenrezeptors GPER1
(2025-03-14)Breast cancer that is negative for the estrogen receptor α (ER α), the progesterone receptor and the human epidermal growth factor receptor 2 is referred to as triple-negative breast cancer (TNBC). This tumor subtype is ... -
TransValid-A-Studie zur präoperativen, 5-FU-basierten Chemo-/Radiotherapie bei Rektumkarzinomen: Machbarkeit, Durchführbarkeit und erste Ergebnisse
(2025-03-14)The single-arm, multicenter TransValid-A study (ClinTrials. gov: NCT03034473; funded by the German Research Foundation, DFG; GZ: LI 1727/3-1) examined under real-world conditions the feasibility and efficacy of 5-fluorouracil ... -
Quantifizierung spontaner Calcium-Freisetzungen in humanen atrialen Kardiomyozyten aus induzierten pluripotenten Stammzellen (iPSC)
(2025-03-13)Atrial fibrillation (AF) is a cardiac disorder characterized by disorganized electrical excitation of the atria. AF is the most common cardiac arrhythmia in clinical practice and is associated with increased cardiovascular ... -
Die Bestimmung der Dichte von Glaskörperproben, Ocriplasmin und verschiedenen Anti-VEGF-Substanzen zur Optimierung der postoperativen Lagerung nach intravitrealer Medikamentenapplikation (IVOM)
(2025-03-13)The dissertation is based on the idea of allowing the drug to migrate into the premacular area through ‘density-appropriate’ patient positioning after intravitreal drug application (IVOM) in the centre of the vitreous body. ... -
Die Rolle der Hedgehog Signalkaskade in Ependymomen
(2025-03-12)In this thesis the activity of Hedgehog (HH) signaling in ependymoma was analyzed. To this end, immunohistochemical stainings were performed on 86 paraffin sections to examine the expression of Sonic Hedgehog (SHH). The ... -
Komplikationen der transseptalen Punktion bei kinderkardiologischen Herzkatheteruntersuchungen im Vergleich zu Komplikationen der transseptalen Punktion im Rahmen von Herzkatheteruntersuchungen bei erwachsenen Patienten
(2025-03-07)Transseptal puncture (TSP) is a standard procedure to obtain access to the left heart in adults with a complication rate ranging from 0,72% to 3.6%. However, data on TSP in infants and children particularly with congenital ... -
Echtzeit-Magnetresonanztomographie zur Evaluation von Atemstörungen bei Patient*innen mit Morbus Pompe
(2025-03-07)Respiratory dysfunction is a major contributor to morbidity and mortality in patients suffering from Pompe disease. Standard diagnostic methods, which aim to evaluate diaphragm weakness, often diagnose it at a later stage ... -
Einfluss regelmäßiger stationärer Beatmungskontrollen auf den Beatmungseffekt und die Compliance bei Patienten mit nichtinvasiver Heimbeatmung
(2025-03-07)Patients with ventilatory insufficiency develop hypercapnia. This can occur acutely or be chronic. If hypercapnia is chronic, there is a metabolic compensation with increased bicarbonate (HCO3-). In cases of chronic ... -
Ethische Herausforderungen der COVID-19-Pandemie im internationalen Vergleich: Erkenntnisse aus 39 Expert*inneninterviews
(2025-03-06)Since spring 2020, the SARS-CoV-2 coronavirus has spread worldwide, causing profound medical, political, economic, cultural, and bioethical challenges in the ensuing pandemic. While the resulting conflicts initially appeared ... -
Untersuchung zur Auswirkung eines Mund-Nasen-Schutzes auf die Mundgesundheit
(2025-03-06)Abstract The aim of this single-center, randomized, exploratory and controlled cross-over observational study was to investigate the influence of cloth, medical and FFP2 masks on saliva parameters and the occurrence of ...