Human- und Zahnmedizin
Recent Submissions
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Funktionelle Charakterisierung von Substitutionsmutationen in Position 566 der Linker-Domäne des onkogenen Transkriptionsfaktors STAT3
(2023-06-08)In this work, the role of two missense mutations in position 566 of the human transcription factor STAT3 (signal transducer and activator of transcription) in relation to the activation of the JAK/STAT signalling pathway ... -
Einfluss von Zoledronat und Denosumab auf humane Zellen der osteoblastären Linie aus dem Kieferknochen anhand osteogener Marker
(2023-06-07)Medication-related osteonecrosis of the jaw is a common complication of antiresorptive therapy. Zoledronate and denosumab are the most widely used and potent drugs for antiresorptive therapy, and at the same time are ... -
Experimentelle Therapie eines Mausmodells für die Pelizaeus-Merzbacher-Erkrankung mit Lonaprisan und Curcumin
(2023-06-05)Pelizaeus-Merzbacher disease (PMD) is a severe x-linked leukodystrophy caused, in the majority of cases, by a duplication of Plp1 coding for Proteolipid Protein. Using a PMD mouse model carrying additional copies of ... -
Bestimmung der mitochondrialen Atmungskettenfunktion im Rett-Syndrom mittels hochauflösender Respirometrie
(2023-06-05)Rett syndrome is a disorder frequently caused by pathological changes in the MECP2 gene, an essential transcription factor. It results in various morphological and biochemical alterations in mitochondria, which affect a ... -
Lebensqualität und Blutdruck in Abhängigkeit von der Geschwisterreihenfolge bei Jugendlichen
(2023-06-02)The associations between blood pressure and sibling status or birth order in adolescents have not been well studied so far. The aim of this study was to investigate the link between sibling order and blood pressure in ... -
Ethische Aspekte von Demenzdörfern: Eine explorative Fokusgruppenstudie zur Sicht von Angehörigen, professionell Pflegenden und der breiteren Öffentlichkeit.
(2023-06-02)In terms of empirical informed ethics, the involvement of affected persons in the ethical discourse is necessary in order to allow their points of view to be considered in the ethical evaluation. This perspective is missing ... -
Der Einfluss von Mikrofluidik auf das Wachstum retinaler Ganglienzellen in vitro
(2023-06-01)Purpose: Low extracellular fluid microfluidics influences the direction of growth and the length of outgrowing neurites. This is methodologically relevant for primary cultures with directed neurite outgrowth. Furthermore ... -
Prognostische Bedeutung einer hyperreflektiven Bande zwischen innerer und äußerer Netzhaut in der OCT bei retinalen Zentralvenenverschlüssen
(2023-06-01)The Aim of the dissertation was to show if a prominent middle limiting membrane sign predicts the clinical course in patients with retinal vein occlusion. We were trying to proof if a pMLM-sign is a predictor for acute ... -
Wirbelsäulenmetastasen – Studie zur Inzidenz neurologischer Defizite mit und ohne vorbekannten Primärtumor
(2023-05-31)Spinal metastases are present in up to 10% of patients with malignancies. In patients who present with metastases in the spine, about one fifth have not previously had a known primary tumour. We took these two elements as ... -
Lipocalin 2 als liquor und plasmabasierter Biomarker bei vaskulärer Enzephalopathie: Assoziationen mit klinischen Merkmalen und verschiedenen Formen der vaskulären Demenz
(2023-05-30)Diagnosing vascular dementia can be a significant challenge due to numerous differential diagnoses and overlapping clinical features. To supplement current neuropsychological and imaging diagnostic tools with an objective ... -
Untersuchungen zur Frage der bilateral asymmetrischen Morphologie des adulten Zebrafischherzens
(2023-05-30)Specification of the right-left body axis plays an important role in the development of vertebrate hearts. The heart is the first organ to acquire a bilaterally asymmetric shape during the embryonic period of development. ... -
Klinische und polysomnografische Charakteristika von Patienten mit Restless-Legs-Syndrom unter Augmentation
(2023-05-30)Restless legs syndrome (RLS), as a circadian movement disorder, can have a high impact on the quality of sleep and everyday life. For RLS-treatment multiple substances including dopamine agonists are recommended in the ... -
Häufigkeit und prognostische Auswirkungen einer rechtsventrikulären Beteiligung am akuten Myokardinfarkt
(2023-05-26)In the western world, acute myocardial infarction and its following injuries are among the most common causes of death, despite falling incidence. Medicine now offers a variety of modern treatment options, including drug ... -
Postoperatives Vorhofflimmern – eine klinische und experimentelle Risikoanalyse
(2023-05-24)Postoperative atrial fibrillation (poAF) is one of the most common complications after cardiac surgery and is associated with increased mortality and morbidity for the patients affected. Since the interplay of clinical and ... -
Die Rolle von ARID1A in Pankreas- und kolorektalem Karzinom
(2023-05-23)Overall, ARID1A showed a strongly context-dependent function in this study (Sun et al. 2017). In particular, in pancreatic tumors, the tumor suppressive function of ARID1A could be partially confirmed in terms of growth ... -
Analysis of the results of traumatic vertebral fractures in the thoracic and lumbar region classified as A3-fractures according to Magerl, supplied by combination of percutaneous posterior transpedicular osteosynthesis and balloon kyphoplasty
(2023-05-22)Kyphoplasty and osteosynthesis is very safe in the treatment of vertebral body fractures. Our study analysed the results of 48 patients with acute vertebral body fractures of lumbar or thoracic spine classified as A3 ... -
Klinische Performance von CAD/CAM-gefertigten Keramik-Teilrestaurationen – ein Vergleich zwischen Studierenden und Zahnärzten
(2023-05-17)The manufacturing process of CAD/CAM ceramic restorations is considered to be complex and technique-sensitive. It has already been shown for various treatment steps of the CAD/CAM workflow that their implementation depends, ... -
Analysis of Expression of RNA Helicases and Cofactors in Human Tissues and Cancer
(2023-05-11)RNA helicases are ubiquitously expressed enzymes that function as key regulators of many different aspects of gene expression. They use their nucleoside triphosphate-dependent activity to drive the remodeling of various ... -
Proteomische Analyse der Nephrotoxizität im Falle der Cyclosporin A und Tacrolimus Therapie
(2023-05-03)Immunosuppressants have made organ transplantation possible as a therapeutic intervention. One of the first and still most important groups of drugs among immunosuppressants are the calcineurin inhibitors, including ... -
Direct optogenetic stimulation of smooth muscle cells to control gastric contractility
(2023-05-02)Rationale: Antral peristalsis is responsible for gastric emptying. Its failure is called gastroparesis and often caused by dysfunction of enteric neurons and interstitial cells of Cajal (ICC). Current treatment options, ...