Human- und Zahnmedizin
Recent Submissions
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AMPK inhibitor-based combination therapies in pancreatic ductal adenocarcinoma
(2025-02-14)Regarding the dismal prognosis of pancreatic ductal adenocarcinoma, this thesis aimed to identify a new therapeutic option by inhibiting the adenosine monophosphate-activated protein kinase (AMPK). Since cancer cells grow ... -
Neodym:YAG-Lasertherapie mukoider Dorsalzysten: Klinische Wirksamkeit und Effekte in einem 3D-Gewebemodell
(2025-02-14)This study evaluates Nd:YAG-laser treatment as a novel therapeutic option for mucoid dorsal cysts, for which no standard procedure currently exists. In the first part, the clinical efficacy and potential of this new treatment ... -
Visualisierung neutrophiler Granulozyten und NETs (Neutrophil Extracellular Traps) mit Expansionsmikroskopie
(2025-02-14)Neutrophil granulocytes are short-lived immune cells which play a significant role in the innate immune system. They are the most abundant immune cell type in the blood as well as part of the first line of defence of the ... -
Biomechanische Analyse der Auswirkung einer Fixierung des Iliosakralgelenks auf relevante Bewegungen
(2025-02-14)Pelvic ring fractures place high demands on treatment due to the severity of the injury. Type B and type C injuries, which are often caused by high-impact trauma and lead to instability of the pelvic ring, are particularly ... -
Phänotypische und funktionelle Charakterisierung der kutanen Immunantwort bei Kontakt mit Natriumlaurylsulfat
(2025-02-14)Sodium lauryl sulfate (SLS) is regularly used as a so-called irritancy control in patch testing in the allergological diagnosis of contact allergies and we encounter it in everyday life, for example in soaps, cleaning ... -
Prospektive Untersuchung von prognostischen Markern des Nierenschadens beim kardiorenalen Syndrom: Erfassung der Auswirkung von SGLT2 Inhibitoren auf Parameter der renalen Kongestion
(2025-02-14)The cardiorenal syndrome, defined as the concurrent occurrence of kidney and heart disease, is a common phenomenon in clinical practice. Renal venous congestion plays a significant role in the pathophysiology and prognosis ... -
Bypass von mRNA-Qualitätskontrolle generiert aberrante EYA1-Isoform in tumorassoziierten Fibroblasten des Pankreas-CA
(2025-02-10)EYA1 plays a key role in the embryonic development of various organs. Further, it has a profibrotic effect, thus influencing the pathogenesis of various diseases and malignancies. Its tyrosine phosphatase activity and ... -
Eine Untersuchung von Biomarker-Profilen bei Patienten im Spektrum zwischen Alzheimer-Demenz und vaskulärer Demenz
(2025-02-10)Developing dementia significantly alters the everyday life and quality of life of the affected patients. In the end stage of dementia, the diseased often experience complete helplessness and need for care. In contrast to ... -
Retrospektive Analyse der Clostridioides difficile-Infektionen vom Jahr 2016 bis zum ersten Tertial des Jahres 2017 im geriatrischen Zentrum des Evangelischen Krankenhauses Göttingen-Weende
(2025-02-10)Background: Clostridioides (C.) difficile is a common pathogen of nosocomial infections. Elderly patients who have received antibiotic therapy are particularly affected. The incidence and severity of C. difficile infections ... -
Machbarkeits-Studie zur Implementierung formativer Key-Feature-Prüfungen in der Zahnmedizin
(2025-02-07)This study examines the feasibility and optimization of formative key feature cases in dental education. The aim was to determine whether this examination format is suitable for capturing critical key aspects of dental ... -
Evaluation des Einflusses einer Beckenfraktur auf klinische Parameter und das Outcome Schwerverletzter eines überregionalen Traumazentrums
(2025-02-06)The prevalence of pelvic fractures has remained constant at 3–8% over the years. Despite continuous advancements in medicine and a general reduction in trauma-related mortality, pelvic ring fractures are often associated ... -
Veränderungen der Ultrastruktur des axonalen Cytoskeletts während der akuten axonalen Degeneration
(2025-02-06)The ultrastructure of the cytoskeleton of axons shows a periodically arranged sub-plasmalemmal membrane skeleton. It is formed by ring-shaped actin filaments and associated membrane proteins and is connected by spectrin ... -
A cross-sectional study on the impact of herbal medicine on the prevalence of bacterial and fungal pathogens in wound infections and surgical site infections in rural Ghana
(2025-02-06)This study was performed to get a better understanding about the use of traditional herbal medicine on wound infection in Ghana, and to analyze possible effects on wound pathogen composition and pathogen resistance. ... -
Outcome und Adhärenz moderierende Faktoren einer intensiven Sportintervention in drei psychiatrischen Störungsentitäten: subjektiver Gesundheitszustand, somatoforme Symptomlast, sportliche Vorerfahrung
(2025-02-06)According to the Global Burden of Disease Study 2010, mental illnesses account for 7.4% of the globally lost healthy life years (Whiteford et al. 2015). Identifying and researching effective therapeutic approaches is ... -
Chondrogene Differenzierung mesenchymaler Stammzellen: Der Einfluss von Hyaluronan und Kollagen-Typ-II auf die Chondrogenese in PEGDA-Hydrogelen
(2025-02-05)The treatment of cartilage defects is challenging since cartilage, as a bradytrophic and avascular tissue, lacks the necessary self-regeneration capacity to adequately repair degenerative, inflammatory or traumatic defects. ... -
Patientenadhärenz in der ambulanten Nachsorge der Frühgeborenenretinopathie an der UMG-Augenklinik
(2025-02-05)Retinopathy of prematurity (ROP) poses a serious risk of lifelong visual impairment or even blindness for affected children, which is why consistent screening examinations are essential. While in the inpatient setting, ... -
Computertomographie bei COVID-19 Pneumonien und pulmonalen Non-COVID Erkrankungen: Diagnostische Genauigkeit der radiologischen Beurteilung und maschineller Lernverfahren
(2025-02-05)Since early 2020, the novel Covid-19 pneumonia has been spreading worldwide and poses a diagnostic challenge. Medical imaging techniques such as computed tomography (CT) play an important role in diagnosing Covid-19. ... -
Finite element analysis investigation of positive reduction in the femoral neck fracture
(2025-02-05)Aim Gotfried positive reduction offers an alternative strategy for femoral neck fracture (FNF) when achieving anatomical reduction is challenging. However, quantifying positive reduction and assessing the potential issues ... -
Untersuchung des Stuhlverhaltens von Neugeborenen in Abhängigkeit von extrinsischen Faktoren (Kohorten Studie)
(2025-02-03)Delayed meconium passage in preterm infants is common in very low birth weight infants, and there is evidence in the literature of a high risk of gastrointestinal complications, particularly in preterm infants of low ... -
Suizidalität bei Depressionen unter repetitiver transkranieller Magnetstimulation
(2025-01-31)Suicidality is a serious global public health problem and is closely associated with depression. There is a need for effective anti-suicidal therapies. rTMS shows promising potential as a modern form of therapy. Due to the ...