Human- und Zahnmedizin
Recent Submissions
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Tau-Protein im Liquor cerebrospinalis in der Differenzialdiagnostik bei Morbus Alzheimer und sporadischer Creutzfeldt- Jakob-Krankheit
(2025-05-12)In der Diagnostik der Alzheimer-Demenz (AD) hat sich das totale Tau (t-Tau) im Liquor als ein wichtiges diagnostisches Mittel etabliert. Allerdings wurden auch bei Patient*innen mit Creutzfeldt-Jakob-Krankheit (CJK) stark ... -
Detektion von Nebenbefunden bei röntgenologischer Bildgebung in der kieferorthopädischen Praxis: eine fragebogenbasierte Untersuchung
(2025-05-09)Background: In orthodontic practice, radiographs with large fields of view - such as orthopantomogram (OPT) and lateral cephalogram (LC) radiographs - are routinely acquired and assessed. The reliability of identifying ... -
Cross-National Analysis of IVF Registry Data
(2025-05-08)Approximately 15% (1 in 6) of couples worldwide face infertility issues, and assisted reproductive technology (ART), which is now adopted globally, has become a key method to address these challenges. Various in-vitro ... -
Der Effekt von Erythropoetin auf das Überleben von Gehirnnervenzellen der Locusta migratoria nach Schädigung durch UV-Strahlung
(2025-05-08)Erythropoietin (Epo) is a well-known candidate for neuroprotection due to its anti-apoptotic properties. One limiting factor in previous studies has been thromboembolic side effects. Various receptors and signaling pathways ... -
Das Potenzial spezifischer methylierter DNA im Blut als Biomarker für die Mortalität bei Herzinsuffizienz mit erhaltener Ejektionsfraktion
(2025-05-07)Chronic heart failure is a leading health risk worldwide for the increasingly ageing population. Patients with heart failure with preserved ejection fraction (HFpEF) account for around half of all cases. Making a valid ... -
Bacteriorhodopsin-like cation channelrhodopsin based optogenetic tools for the future optical cochlear implant
(2025-05-07)Deafness is a widespread and severe condition. Electrical cochlear implants, which use electrical stimulation of the auditory nerve, enable speech comprehension in those patients suffering from sensorineural hearing loss. ... -
Kardiale Magnetresonanztomographie: Semiautomatische dreidimensionale Analyse und Visualisierung linksatrialer struktureller Veränderungen
(2025-04-30)Background: Catheter ablation is an established treatment for atrial fibrillation (AF), yet its efficacy, particularly for first-time procedures, is influenced by the degree of left atrial (LA) structural remodeling - most ... -
Auswirkung der klinischen MRT-Auswertung auf die Detektionsrate des Prostatakarzinoms im Rahmen der MRT/TRUS-Fusionsbiopsie der Prostata
(2025-04-30)Prostate carcinoma is the most frequently diagnosed cancer in men in Germany. It is crucial to recognise clinically significant carcinomas at an early stage. Prostate biopsy is the preferred diagnostic method for this. ... -
Identification of differentially m6A methylated circRNAs in patient derived RBM20 mutated and control iPS-Cardiomyocytes
(2025-04-30)Approximately 5% of dilated cardiomyopathies are caused by a mutation in the RBM20 gene, which encodes a protein involved in the splicing of cardiac specific titin and formation of cTTNs, the titin specific circRNA. Although ... -
Auswirkungen der Maskenpflicht auf die Arzt-Patienten-Kommunikation bei Patienten mit Tumoren im Mund-, Kiefer- und Gesichtsbereich
(2025-04-29)To contain the rapid spread of SARS-CoV-2, the mandatory wearing of face masks was a key component of COVID-19 safety measures during the pandemic. This mask mandate was repeatedly subject to controversial debate. As a ... -
Varianten im Dihydropyrimidin-Dehydrogenase-Gen (DPYD) bei Patienten mit Rektumkarzinomen unter adjuvanter, 5-FU-haltiger Chemotherapie – eine monozentrische Analyse aus der GAST-05-Studie
(2025-04-29)In this monocentric posthoc study the impact of occult mutational DPYD status in patients with adenocarcinomas (stages ≥ II) of the upper rectum was investigated towards the occurrence of CTC-AEs (Common-Toxicity-Criteri ... -
FBRSL1 und seine Assoziation zum Polycomb-Komplex: Interaktionspartner und transkriptionaler Einfluss auf Zielgene
(2025-04-28)Zusammenfassung Englisch At the University of Göttingen three children with similar congenital symptoms were genetically tested, and variants in the FBRSL1-Gene were found in all of them. During my thesis work, I tested ... -
Dysfunktionen des autonomen Nervensystems bei adulter Aufmerksamkeitsdefizit- / Hyperaktivitätsstörung
(2025-04-28)Autonomic system dysfunction has been reported in children and adolescents with attention deficit hyperactivity disorder (ADHD) and may be related to their behavioural characteristics. However, findings are inconsistent ... -
Neurodegenerationsmarker im Verlauf eines 6-wöchigen hochfrequenten standardisierten Sportprogramms (SIWAS) in 3 Gruppen Psychiatrischer Erkrankungen
(2025-04-28)This study investigated the effects of a six-week, structured physical exercise program on neurodegenerative biomarkers in patients with schizophrenia, depression, or substance use disorders. A total of 61 participants ... -
Proteomische Analyse des kleinzelligen Lungenkarzinoms
(2025-04-28)Small cell lung carcinoma belonging to the group of neuroendocrine tumors of the lung is an aggressive and rapidly progressing tumor disease with a poor prognosis. Significant progress in the treatment of patients with ... -
Evaluation der nicht-invasiven Leberelastizitäsmessung mittels 2D-Scherwellen-Elastographie (LOGIQ E9 shear wave elastography) im Verlauf der Gewichtsreduktion bei Adipositas im Rahmen des Therapiekonzeptes OPTIFAST®-52
(2025-04-24)Due to its high prevalence and potentially asymptomatic course, non-alcoholic fatty liver disease (NAFLD) remains a challenge in medicine. NAFLD may progress to non-alcoholic steatohepatitis (NASH) and eventually lead to ... -
Verschlussrate sowie intra- und postoperative Komplikationen nach Makulalochchirurgie
(2025-04-23)The full thickness macular hole is a vision threatening condition and without treatment the risk of permanent and severe vision loss is high. Currently, the only established and standard treatment for full thickness macular ... -
Endoplasmatischer Retikulum-Stress im Zellkulturmodel für chronische Muskelentzündungen
(2025-04-23)Background: Inclusion body myositis (IBM) is an acquired myopathy in individuals over the age of fifty. It is characterized by progressive muscle atrophy and weakness that leads to severe disability. Currently there is no ... -
Longitudinal Structural Voxel based Morphometry of 1.5 tesla MRI in early Parkinson’s disease
(2025-04-23)Parkinson’s disease is a multisystemic, progressive neurodegenerative disorder characterized by the gradual loss of dopaminergic neurons in the substantia nigra, resulting in a wide range of motor and non-motor symptoms ... -
Morphologische und mechanistische Analyse des Wachstums retinaler Ganglienzellen unter Einfluss von Mikrofluidik in vitro
(2025-04-22)Replacing retinal ganglion cells (RGCs) in a degenerated optic nerve is not yet possible but may become feasible in the future through stem cell transplantation. Microfluidic fluid streams, presumably present in the optic ...