Human- und Zahnmedizin
Recent Submissions
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Tumor vessel normalization through inhibition of glycolysis in colorectal carcinoma
(2024-09-16)The current treatment approach for CRC involves a combination of surgery and neoadjuvant chemo- and RT. However, drug resistance and recurrence remain significant challenges, emphasizing the need for new and more effective ... -
Evaluation MikroRNA-basierter Biomarker für das Karzinom der Mundhöhle: hsa-miR-149-5p und hsa-miR-182-5p als neue Prognosemarker
(2024-09-16)Oral squamous cell carcinoma (OSCC) is among the leading cancer types worldwide and a major cause of cancer morbidity and mortality: The 5-year-survival rate remains less than 50% due to high rates of recurrence and lymph ... -
Fragebogenstudie zur Quantifizierung von Wirkfaktoren des therapeutischen Milieus durch Patienten und Mitarbeiter in Rehakliniken für psychosomatische Medizin und Kinder- und Jugendmedizin
(2024-09-13)Background: The therapeutic milieu (TM) is probably an important factor for successful rehabilitation in psychosomatic and child and youth rehabilitation. A newly developed questionnaire should have possible uses in both ... -
Einfluss medikamentöser Inhibition des Phosphoinositid-3-Kinase Signalwegs auf die Regulation mitochondrialer Apoptose in peripheren T-Zell Lymphomen
(2024-09-13)Peripheral T-cell lymphomas are a group of genetically heterogeneous and aggressive diseases. Poor tumor response to CHOP-based chemotherapy protocols and a lack of treatment options in relapses lead to a generally poor ... -
Die Auswirkungen von ∆9-Tetrahydrocannabinol auf Gedächtnisstörungen und die Aβ-Pathologie im 5xFAD-Mausmodell
(2024-09-13)Alzheimer´s disease (AD) is the leading cause for dementia worldwide. It is characterized by a progredient cognitive decline, memory deficits and deposits of proteins called Amyloid beta (Aβ). Familial AD is characterized ... -
The Role of Hydrogen Peroxide on Nuclear Actin Dynamics in Hypoxia
(2024-09-13)With an increasing interest in the dynamics of the highly conserved protein actin and the signaling function of reactive oxygen species, this thesis aimed to discover if changes in reactive oxygen species production, ... -
Vergleichende Analyse zweier Operationsplanungsverfahren für die Unterkieferrekonstruktion mit freien Knochentransplantaten hinsichtlich der postoperativen Präzision nach umfangreicher ablativer Chirurgie im Kopf-Hals-Bereich
(2024-09-12)Oral squamous cell carcinoma is one of the most common cancers worldwide. In advanced tumor stages, the tumor cells often grow invasively into the adjacent mandibular bone, making partial resection necessary. Both tumor ... -
NF-κB in dermaler Homöostase in vitro
(2024-09-11)Although systemic sclerosis is considered a rare disease, there are no curative therapeutic approaches to date and patients develop fibrotic remodeling processes throughout the body over time in addition to skin fibrosis, ... -
Untersuchung der Wirkung eines Impfstoffes gegen Harnwegsinfektionen auf das angeborene Immunsystem
(2024-09-10)The treatment of urinary tract infections is usually accompanied by a high consumption of antibiotics, which are used for the treatment of acute urinary tract infections, but also in low doses for long-term prophylaxis ... -
The role of RORβ in human iPSC derived cardiomyocytes
(2024-09-10)Every year systolic heart failure contributes immensely to the death tolls in industrialized nations. However, little is known about the molecular mechanisms underlying this devastating disease. Based on the RNA sequencing ... -
Notwendigkeit einer Druckadjustierung im Follow-up einer nCPAP/BiPAP-Anpassung
(2024-09-10)Obstructive sleep apnoea (OSA) is one of the most common sleep-related breathing disorders (SBAS) with increasing prevalence in industrialised nations and socio-economic consequences. Nocturnal positive airway pressure ... -
Evaluation of desmoplastic and replacement type histopathological growth patterns of colorectal cancer liver metastases at single-cell resolution
(2024-09-10)This thesis project evaluated molecular differences between desmoplastic and replacement colorectal liver metastases, with the focus on the heterogeneity between ECs in livers colonized by CRCLM. Stratifying the sample ... -
Studie zum aktuellen Stand der intersektoralen Zusammenarbeit – Eine Umfrage zur Perspektive der niedergelassenen Ärztinnen und Ärzten in Deutschland
(2024-09-09)Intersectoral cooperation in the health care system at the interfaces between the ambulatory and hospital sectors is of great importance for patient health. For example, poor or delayed communication at discharge increases ... -
Untersuchung der Assoziation zwischen Dopplerkurvencharakteristika der extrakraniellen, hirnversorgenden Gefäße und Aortenklappenvitien
(2024-09-06)Stroke is a common illness, particularly among older people, and in times of demographic change causes high costs for the healthcare system. A common risk factor for a stroke is thromboembolism, which can arise, for example, ... -
Vergleich der einseitigen und zweiseitigen Osteotomie im osteoporotischen Rattenmodell
(2024-09-06)The aim of this work was to heal a unilateral (UL) with bilateral (BL) osteotomy in the osteoporotic rat model. The assumption was that a UL osteotomy would result in an uneven Stress on the limbs occurs and this ... -
Die Wirkung von additiver systemischer Lysetherapie zur mechanischen Therapie auf das funktionelle Outcome in Schlaganfallpatient*innen mit proximalem Gefäßverschluss (LVOS) der vorderen Zirkulation
(2024-09-04)Background: Endovascular treatment (EVT) represents a highly effective intervention for the management of large vessel occlusion stroke (LVOS). The question of whether intravenous thrombolysis (IVT) prior to endovascular ... -
Erhalt des Restgehörs nach Insertionstrauma der Cochlea durch Applikation von Etanercept in die Scala tympani des Meerschweinchens
(2024-09-04)Objective: Cochlear implantation trauma causes both macroscopic and inflammatory trauma. The aim of the present study was to evaluate the effectiveness of the TNF-alpha inhibitor etanercept applied after cochlear implantation ... -
Einfluss antiepileptischer Medikamente auf die funktionelle Konnektivität im Routine-EEG bei Patienten mit fokaler nicht-läsioneller Epilepsie
(2024-09-04)Epilepsy is one of the most important neurological disorders and affects up to 1% of the population in Germany (Brandt 2016). It is currently not possible to make a reliable statement on the prognosis and effectiveness of ... -
T1-Mapping des zervikalen Myelons bei degenerativer zervikaler Spinalkanalstenose
(2024-09-03)Cervical spinal canal stenosis is a common disease of the elderly and can cause a variety of symptoms. There are currently no standardised and clear treatment recommendations regarding the right treatment modality for ... -
Klinisches, neurophysiologisches und genetisches Spektrum der hereditären motorisch-sensiblen Neuropathien im Kindes- und Jugendalter. Eine retrospektive Datenauswertung der Patient*innen der Neuropädiatrie Göttingen aus den Jahren 2000 – 2017
(2024-09-02)In this retrospective, single-center observational study, the clinical, neurophysiological, and genetic spectrum of CMT neuropathies in childhood and adolescence is examined based on 49 patients who were treated at the ...