Human- und Zahnmedizin
Recent Submissions
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Vorhersagbarkeit der postoperativen Zielrefraktion bei kombinierter Katarakt- und Netzhautoperation
(2025-06-24)With increasing age, the prevalence of lens opacification (cataract) rises, as does the number of vitreoretinal diseases that can be treated with vitreoretinal surgery (vitrectomy). In phakic patients, vitrectomy accelerates ... -
Systematische Recherche und Bewertung von Krankenhausnavigatoren in Deutschland hinsichtlich ihrer Vergleichbarkeit anhand von operativen Ergebnissen und Patientenzufriedenheit am Beispiel der radikalen Prostatovesikulektomie
(2025-06-24)Background: Hospital navigation tools provide online information about treatment quality and patient satisfaction, but their comparability and methodological robustness remain unclear. Objective: This study aimed to ... -
Fluorespirometrische Charakterisierung mitochondrialer Dysfunktion der Hirnregionen Cortex und Hippocampus eines Mausmodells für das Rett-Syndrom
(2025-06-24)Rett syndrome, typically caused by mutations in Methyl-CpG-binding protein 2 (Mecp2), is a severe neurodevelopmental disorder. Mitochondrial dysfunction is implicated as a significant factor in its pathogenesis. This study ... -
The role of CXCR4 in endothelial-to-mesenchymal transition and cardiac fibrosis
(2025-06-24)Cardiac fibrosis contributes critically to the deterioration of heart function in numerous cardiovascular disorders by disrupting normal tissue structure and compliance,which characterized by excessive extracellular matrix ... -
Modulation der zytosolischen Redox-Balance durch aktivitätsinduzierte Ca2+-Signale in hippokampalen Neuronen der Maus
(2025-06-24)Intracellular Ca2+ signals are essential for the modulation of cellular activity and excitability but also represent critical components of cellular dysfunction and damage in various neurological disorders. The aim of this ... -
Zerebrale Kartierung der neuronalen Redox-Veränderung in einem Maus-Modell für das Rett-Syndrom
(2025-06-24)As part of this study, changes in the neuronal redox balance in the brains of Rett mice are mapped and correlated with the progression of Rett syndrome. Fluorescence microscopy techniques (primarily ratiometric CCD camera ... -
Funktionelles Apoptose-Profiling zur Weiterentwicklung zielgerichteter Therapien für die adulte T-Zell akute lymphatische Leukämie (T-ALL)
(2025-06-23)T-cell acute lymphoblastic leukaemia is a very aggressive haematological neoplasia characterised by malignantly transformed precursor T-lymphocytes. Considering the poor prognosis and limited treatment options for affected ... -
Einschränkungen und unfallbedingte Dauer der Arbeitsunfähigkeit / der beruflichen Tätigkeit nach Wirbelsäulenverletzung
(2025-06-23)The traumatic vertebral fracture is a common injury in trauma surgery, that is most often related to men in employable age. So far there are only a few statements regarding the duration of incapacity to work, which the ... -
Reevaluation der standardisierten CCT - Kontrollbildgebung bei Kindern nach neurochirurgischer Tumorresektion
(2025-06-19)After surgical interventions in the field of neurosurgery, postoperative cranial imaging using computed tomography (CCT) was used as a standard control procedure. The aim was to detect or rule out any therapeutically ... -
Network Activity of Antibody Targeted and α/ β -Synuclein Transfected Neurons
(2025-06-16)Parkinson’s disease (PD), is characterised pathologically by a loss of dopaminergic neurons in the substantia nigra pars compacta and concomitant aggregation of the pre-synaptic protein α-synuclein (α-syn), mitochondrial ... -
In-vivo-Biofilmakkumulation auf Prothesenkunststoffen
(2025-06-12)INTRODUCTION: Denture base resins, such as heat- and cold-polymerized PMMA, as well as newer materials like CAD/CAM-PMMA and Polyamide-12, are widely used in removable dentures. Their long-term oral presence makes them ... -
Cardiomyocyte-specific Activation of the Insulin-like Growth Factor Binding Protein 5 (IGFBP5) in the Postnatal Heart Via CRISPR/Cas9
(2025-06-12)IGFBP5 is one of six proteins that bind insulin-like growth factors (IGFs) and is known to regulate processes such as cell growth, aging, and metabolism. Previous studies have shown that its transcription is elevated in ... -
Mikro CT-, Histomorphometrische- und Immunhistologische Analyse 3D gedruckter PLLA/CaCO3- Scaffolds mit Zusatz von CaPO4 im Göttinger Minipig zur Entwicklung eines patientenspezifischen, resorbierbaren Knochenersatzmaterials
(2025-06-12)Introduction: One of the central challenges in oral and maxillofacial surgery is the reconstructive restoration of tissue defects following extensive tumor resections in the head and neck region. Microvascular free tissue ... -
Retrospektive Einwilligung zur rtPA-Lysetherapie bei intrazerebraler Blutung in Abhängigkeit vom funktionellen Outcome und der gesundheitsbezogenen Lebensqualität
(2025-06-11)Spontaneous intracerebral hemorrhage (ICH) might lead to devastating consequences. Nonetheless, subjective interpretation of life circumstances might vary. Recent data from ischemic stroke patients show that there might ... -
Korneale Konfokalmikroskopie am Auge zur Beurteilung von Nervenfasern der Kornea bei Patient*innen mit Hereditär Motorisch-sensiblen Neuropathien
(2025-06-11)Hereditary motor and sensory neuropathies (HMSN) represents a group of genetically heterogenous inherited neuropathies. No therapy is available and biomarkers are difficult to validate due to slow disease progression. ... -
Entgiftung bei Alkoholabhängigen mit Clomethiazol oder Diazepam - Vergleich von Behandlungsvariablen
(2025-06-11)Background: Current guidelines on alcohol-related disorders recommend pharmacological treatment of alcohol withdrawal syndrome (AWS) based on symptom severity. In Germany, benzodiazepines—particularly diazepam—or clomethiazole ... -
Auswirkungen der linksseitigen kardialen sympathischen Denervation auf die Arrhythmielast und das vegetative Nervensystem bei jungen Patienten mit therapierefraktären ventrikulären Tachyarrhythmien bei LQTS und CPVT
(2025-06-10)The effectiveness of LCSD (left cardiac sympathetic denervation) in controlling therapy-refractory ventricular tachyarrhythmias and reducing the risk of sudden cardiac death in LQTS (Long QT Syndrome) and CPVT (Catecholaminergic ... -
Selbstbestimmtes Handeln am Lebensende – Autonomie und Vertrauen in der Interaktionsdynamik von Patient*innen und ihren Angehörigen
(2025-06-05)In addition to medical care, family members are an important foundation for patient autonomy. At the end of life, patients can only act independently with support—be it in everyday tasks or in mental support. This study ... -
Systematisches Review und Metaanalyse publizierter Fallberichte zu Multipler Sulfatase Defizienz
(2023-06-23)Multiple Sulfatase Deficiency (MSD, MIM #272200) is an ultra-rare lysosomal storage disorder that results from mutations in the SUMF1 gene, which encodes formylglycine-generating enzyme (FGE). Pathogenic variants in SUMF1 ... -
Charakterisierung von Patient:innen mit niedriger alkalischer Phosphatase
(2025-06-04)Patients with hypophosphatasia have limited health and quality of life. It is currently controversial whether patients with a heterozygous mutation actually have any significant clinical symptoms. On the other hand, the ...