Recent Submissions
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Treffsicherheit der von Notärzten gestellten Verdachtsdiagnose eines ischämischen oder eines hämorrhagischen Schlaganfalls
(2024-10-04)Stroke is the second most common cause of death worldwide and a frequent emergency in the emergency services. The definition of a stroke is an acute neurological deficit due to a lesion in the central nervous system. A ... -
In-vitro-Untersuchung der Zytotoxizität der synthetischen Nanomaterialien Kohlenstoffnanohörner und CdSe/CdS Nanostäbchen
(2024-10-04)As the variety and quantity of synthetic nanoparticles produced increases, so does the potential for inhalation uptake, including as free and airborne pollutants. This work investigated effects of synthetic nanomaterials ... -
Diagnostik, Prävalenz und molekulare Charakterisierung von Clostridioides difficile im ländlichen Ghana
(2024-10-01)This study investigated the role of Clostridioides difficile (C. difficile) as a cause of diarrheal diseases in rural Ghana. Between November 2013 and September 2014, 176 stool samples from diarrhea patients and 131 samples ... -
RT-QuIC-Assay zur Detektion von BSE in Rindern im Vergleich zu anderen Proteinaggregat-Detektionsverfahren
(2024-09-25)Bovine spongiform encephalopathy (BSE) is a transmissible neurodegenerative disease with fatal outcome. Occurring in cattle it can be transferred to humans via the food chain causing variant Creutztfeldt-Jakob disease ... -
Manueller Long-Axis-Strain in der kardialen Magnetresonanztomographie zur Approximierung der linksatrialen Funktion und Risikoprädiktion nach Myokardinfarkt
(2024-09-25)The goal of this dissertation was to retrospectively assess the prognostic utility of left atrial long axis strain (LA LAS) in cardiac magnetic resonance imaging in a study population of two multicentric studies of survivors ... -
Die Rolle der Glykogen Synthase Kinase 3β in der Regulation von DNS-Schäden und Chemotherapieresistenz im Pankreaskarzinom
(2024-09-24)Pancreatic carcinoma is one of the most aggressive solid tumour types and is characterized by pronounced molecular heterogeneity. Research is continuing into molecularly definable subgroups that are suitable for targeted, ... -
Pankreatisch zystische Neoplasien und das orointestinale Mikrobiom: Evaluierung als Biomarker
(2024-09-24)Pancreatic cystic neoplasms (PCN) are mostly benign cystic lesions of the pancreas, which can be a precursor lesion for pancreatic cancer. The risk of malignancy varies widely, depending on the entity of the PCN. Despite ... -
Die Identifikation transkriptioneller Biomarker für periphere Polyneuropathien
(2024-09-24)Peripheral polyneuropathies are a heterogeneous group of widespread diseases of the peripheral nerves that can be caused by numerous factors. Differentiating between different types of polyneuropathies and identifying their ... -
Die Auswirkungen von Tenalisib und Ruxolitinib auf Hodgkin-Lymphom-Zellen und Makrophagen sowie auf deren Interaktion
(2024-09-24)Recent research on Hodgkin lymphoma has shown that the tumor microenvironment, particularly macrophages, plays a role in the development and progression of lymphomas. The underlying mechanisms and the potential therapeutic ... -
Der Einfluss genetischer Mutationen im CIC-Gen auf den Folattransport
(2024-09-23)In this dissertation, we studied the influence of the capicua protein on the expression of proteins that are involved in transcellular folate transport. To this end, various expressions of the capicua gene were studied: ... -
The role of regulatory B cell properties in multiple sclerosis - future therapeutic implications
(2024-09-23)Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous system which affects 2.8 million people worldwide. Most likely, B cells play an important role in its immunopathogenesis, however, they also ... -
Stellenwert der Radiowellen-Technologie in der bildgebenden Mammadiagnostik (Klinische Evaluation des Systems "MARIA")
(2024-09-20)An examination procedure for the detection of breast cancer (“MARIA”) is presented, which has been in the testing and optimization phase for years. In an intra-individual comparative study, 109 consecutive women who were ... -
Retrospektiver und prospektiver Vergleich der klinischen Performance des CertasPlus- mit dem proGAV 2.0-Shuntventil zur Behandlung von Hydrocephalus-Patientenf
(2024-09-20)Implantation of a vp-shunt represents the current standard of care in hydrocephalus patients. Both combination valves implanted in this study contain a proprietary differential pressure valve, which is combined with a ... -
Sicherheit und Effektivität der Verwendung von Plastikfolien bei der Erstversorgung sehr kleiner Frühgeborener mit einem Geburtsgewicht <1500 g und/oder einer Reife <32 SSW
(2024-09-19)Guidelines advise for more than 20 years to use occlusive plastic wraps for temperature management during delivery room care. In contrast, data on microbial safety and efficacy of different types of wrap are still ... -
Versuche zur Etablierung von CrisprCas9 in chondrogenen Progenitorzellen
(2024-09-17)Osteoarthritis is the most common form of joint disease and is therefore one of the main causes of mobility limitations in older age. Current treatment models do not yet include curative therapies. The “Oral Biology and ... -
Pathologie und Klinik der eosinophilen Ösophagitis
(2024-09-17)Eosinophilic oesophagitis is an inflammatory disease of the oesophagus characterised by dense infiltration of the oesophageal mucosa with EoGr and the presence of esophageal symptoms. Diagnosis is histopathologically ... -
Tumor vessel normalization through inhibition of glycolysis in colorectal carcinoma
(2024-09-16)The current treatment approach for CRC involves a combination of surgery and neoadjuvant chemo- and RT. However, drug resistance and recurrence remain significant challenges, emphasizing the need for new and more effective ... -
Evaluation MikroRNA-basierter Biomarker für das Karzinom der Mundhöhle: hsa-miR-149-5p und hsa-miR-182-5p als neue Prognosemarker
(2024-09-16)Oral squamous cell carcinoma (OSCC) is among the leading cancer types worldwide and a major cause of cancer morbidity and mortality: The 5-year-survival rate remains less than 50% due to high rates of recurrence and lymph ... -
Fragebogenstudie zur Quantifizierung von Wirkfaktoren des therapeutischen Milieus durch Patienten und Mitarbeiter in Rehakliniken für psychosomatische Medizin und Kinder- und Jugendmedizin
(2024-09-13)Background: The therapeutic milieu (TM) is probably an important factor for successful rehabilitation in psychosomatic and child and youth rehabilitation. A newly developed questionnaire should have possible uses in both ... -
Einfluss medikamentöser Inhibition des Phosphoinositid-3-Kinase Signalwegs auf die Regulation mitochondrialer Apoptose in peripheren T-Zell Lymphomen
(2024-09-13)Peripheral T-cell lymphomas are a group of genetically heterogeneous and aggressive diseases. Poor tumor response to CHOP-based chemotherapy protocols and a lack of treatment options in relapses lead to a generally poor ...