Human- und Zahnmedizin
Recent Submissions
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Reevaluation der standardisierten CCT - Kontrollbildgebung bei Kindern nach neurochirurgischer Tumorresektion
(2025-06-19)After surgical interventions in the field of neurosurgery, postoperative cranial imaging using computed tomography (CCT) was used as a standard control procedure. The aim was to detect or rule out any therapeutically ... -
Network Activity of Antibody Targeted and α/ β -Synuclein Transfected Neurons
(2025-06-16)Parkinson’s disease (PD), is characterised pathologically by a loss of dopaminergic neurons in the substantia nigra pars compacta and concomitant aggregation of the pre-synaptic protein α-synuclein (α-syn), mitochondrial ... -
In-vivo-Biofilmakkumulation auf Prothesenkunststoffen
(2025-06-12)INTRODUCTION: Denture base resins, such as heat- and cold-polymerized PMMA, as well as newer materials like CAD/CAM-PMMA and Polyamide-12, are widely used in removable dentures. Their long-term oral presence makes them ... -
Cardiomyocyte-specific Activation of the Insulin-like Growth Factor Binding Protein 5 (IGFBP5) in the Postnatal Heart Via CRISPR/Cas9
(2025-06-12)IGFBP5 is one of six proteins that bind insulin-like growth factors (IGFs) and is known to regulate processes such as cell growth, aging, and metabolism. Previous studies have shown that its transcription is elevated in ... -
Mikro CT-, Histomorphometrische- und Immunhistologische Analyse 3D gedruckter PLLA/CaCO3- Scaffolds mit Zusatz von CaPO4 im Göttinger Minipig zur Entwicklung eines patientenspezifischen, resorbierbaren Knochenersatzmaterials
(2025-06-12)Introduction: One of the central challenges in oral and maxillofacial surgery is the reconstructive restoration of tissue defects following extensive tumor resections in the head and neck region. Microvascular free tissue ... -
Retrospektive Einwilligung zur rtPA-Lysetherapie bei intrazerebraler Blutung in Abhängigkeit vom funktionellen Outcome und der gesundheitsbezogenen Lebensqualität
(2025-06-11)Spontaneous intracerebral hemorrhage (ICH) might lead to devastating consequences. Nonetheless, subjective interpretation of life circumstances might vary. Recent data from ischemic stroke patients show that there might ... -
Korneale Konfokalmikroskopie am Auge zur Beurteilung von Nervenfasern der Kornea bei Patient*innen mit Hereditär Motorisch-sensiblen Neuropathien
(2025-06-11)Hereditary motor and sensory neuropathies (HMSN) represents a group of genetically heterogenous inherited neuropathies. No therapy is available and biomarkers are difficult to validate due to slow disease progression. ... -
Entgiftung bei Alkoholabhängigen mit Clomethiazol oder Diazepam - Vergleich von Behandlungsvariablen
(2025-06-11)Background: Current guidelines on alcohol-related disorders recommend pharmacological treatment of alcohol withdrawal syndrome (AWS) based on symptom severity. In Germany, benzodiazepines—particularly diazepam—or clomethiazole ... -
Auswirkungen der linksseitigen kardialen sympathischen Denervation auf die Arrhythmielast und das vegetative Nervensystem bei jungen Patienten mit therapierefraktären ventrikulären Tachyarrhythmien bei LQTS und CPVT
(2025-06-10)The effectiveness of LCSD (left cardiac sympathetic denervation) in controlling therapy-refractory ventricular tachyarrhythmias and reducing the risk of sudden cardiac death in LQTS (Long QT Syndrome) and CPVT (Catecholaminergic ... -
Selbstbestimmtes Handeln am Lebensende – Autonomie und Vertrauen in der Interaktionsdynamik von Patient*innen und ihren Angehörigen
(2025-06-05)In addition to medical care, family members are an important foundation for patient autonomy. At the end of life, patients can only act independently with support—be it in everyday tasks or in mental support. This study ... -
Systematisches Review und Metaanalyse publizierter Fallberichte zu Multipler Sulfatase Defizienz
(2023-06-23)Multiple Sulfatase Deficiency (MSD, MIM #272200) is an ultra-rare lysosomal storage disorder that results from mutations in the SUMF1 gene, which encodes formylglycine-generating enzyme (FGE). Pathogenic variants in SUMF1 ... -
Charakterisierung von Patient:innen mit niedriger alkalischer Phosphatase
(2025-06-04)Patients with hypophosphatasia have limited health and quality of life. It is currently controversial whether patients with a heterozygous mutation actually have any significant clinical symptoms. On the other hand, the ... -
Eine randomisierte prospektive Kohortenstudie: Präventiver Effekt verschiedener Hangboardtrainingsmethoden zur Stärkung des muskuloskelettalen Systems der Hand
(2025-06-04)Improving climbing performance strongly depends upon effective training methods. Hangboard training is one of the most popular approaches to increase finger and forearm strength. Training protocols are based on maximizing ... -
Einstellungen von Patientenorganisationen zu personalisierter Medizin und Big Data – Eine empirisch-ethische qualitative Studie
(2025-06-03)Background: Within only a few decades, ongoing developments and innovations in digitalization processes have led to a rapid accumulation of extensive data sets across various fields and contexts, including medical and ... -
Künstliche Intelligenz in der Röntgen-Thorax-Analyse auf einer Intensivstation: Eine retrospektive Studie
(2025-05-28)Supine chest radiographs are among the most frequently performed imaging studies in intensive care units. This study investigates the effect of an artificial intelligence (AI)-based system on the diagnostic performance and ... -
Die prädiktive Aussagekraft von BNP und NT-pro BNP für Vorhofflimmern bei Patienten über 75 Jahren in der Primärversorgung (Daten der SCREEN-AF Studie)
(2025-05-27)Atrial fibrillation (AF) is a common supraventricular arrhythmia that predominantly affects older adults, constituting a significant risk factor for ischemic stroke. Its frequent asymptomatic and paroxysmal presentation ... -
Die COVID-19-Pandemie als Prüfstein für gerechte Ressourcenverteilung im Krankenhaus
(2025-05-27)This dissertation examines the issue of equitable resource allocation in five hospitals during the initial phase of the COVID-19 pandemic, using qualitative expert interviews. The study responds to ethical and organizational ... -
SHISA3, a novel Wnt-dependent Signature in the Developing and Failing Heart
(2025-05-27)Understanding how vascular cells develop can be used to discover new paths of cell renewal within the diseased heart, with a particular focus on the epicardium for cardiac regeneration. Previous studies have shown that ... -
Living cell super resolution microscopy of intact cardiac nanodomains in a GFP-reporter-mouse-model
(2025-05-26)The aim of this thesis is to validate the first application of RESOLFT imaging in a transgenic mouse model in order to confirm a novel transgenic-microscopic approach and from there on address relevant questions in cardiac ... -
2D-Shear-wave Elastographie zur Evaluation der Lebersteifigkeit bei systemischer Sklerodermie und primärer biliärer Cholangitis
(2025-05-26)2D Shear-wave elastography (2D-SWE) is a simple, proven, and inexpensive method for determining the liver stiffness (LS). In the present study, we examined the LS using 2D-SWE in patients with systemic sclerosis (SSc) and ...