Human- und Zahnmedizin
Recent Submissions
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Charakterisierung der spezifischen, T-Zell- vermittelten Immunitätslage gegen das Severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) bei Risikogruppen (IMMUNEBRIDGE_ED)
(2025-07-14)Purpose The aim of the study was to characterise the specific T-cell mediated immune response in at-risk groups of patients for a potential severe course of COVID-19. Methods This dissertation uses population based-data ... -
Pleiotrope Effekte Empagliflozins auf humanes und murines Myokard
(2025-07-14)Heart failure with preserved ejection fraction (HFpEF) remains a clinical challenge with limited treatment options. Empagliflozin, a sodium-glucose co-transporter 2 (SGLT2) inhibitor, has been shown to reduce cardiovascular ... -
Axonale Schädigung und Makrophageninfiltration bei Entmarkungserkrankungen
(2025-07-14)Even though the etiology of multiple sclerosis (MS) has been of scientific interest for a long time, it still remains unclear what exactly causes the axonal damage leading to neurological dysfunction. Especially since ... -
Kulturelle Adaptation und psychometrische Validierung der APS-GE
(2025-07-14)Over the past decades, evidence has been provided indicating that individual and highly complex factors contribute to the chronification of chronic pain, a process that can only be fully understood within a biopsychosocial ... -
Evaluation nicht-neoplastischer Veränderungen des Nierenparenchyms als Prädiktoren akuter Nierenschädigung nach Nephrektomie
(2025-07-14)Objective: The aim of this study was to evaluate non-neoplastic parenchymal changes in the kidney as predictors of acute kidney injury (AKI) after radical tumour nephrectomy. Methods: Data from 135 patients with renal ... -
Die Auswirkung verschiedener Cathepsin D Mutationen auf die zelluläre Autophagie
(2025-07-04)The subtypes of neuronal ceroid lipofuscinosis (NCL) cumulatively represent the most common cause of neurodegeneration in children and adolescents. These disorders are characterized by progressive intraneuronal accumulation ... -
Einfluss der operativen Versorgung einer epiretinalen Gliose auf das Binokularsehen und auf die Aniseikonie
(2025-07-04)Introduction: Patients undergoing peeling surgery for epiretinal membrane occasionally complain of binocular visual disturbances postoperatively. The aim of this study was to record subjective complaints and the correlation ... -
Klinische Validierung einer mobilen 4D-Kamera und Entwicklung einer Analysemethodik für mimische Bewegungen vor dem Hintergrund der kombiniert kieferorthopädisch-kieferchirurgischen Therapie
(2025-07-04)Background: Facial expressions are a key component of social interaction and psychological well-being. In the context of combined orthodontic-orthognathic treatment for skeletal dysgnathia, dynamic aspects of facial motion ... -
Charakterisierung von NFATc1 in der tumorassoziierten Kachexie beim duktalen Adenokarzinom des Pankreas im murinen Modell
(2025-07-01)Cachexia is a multifactorial wasting syndrome, defined by a loss of lean body mass and characterized by altered metabolism and systemic inflammation. It is particularly evident in pancreatic cancer (PDAC) where it is ... -
CRISPR/Cas9 Activation of Delta-like non-canonical Notch ligand 1 (DLK1) to Protect from Contractile Dysfunction in Engineered Human Myocardium
(2025-07-01)Delta-like non-canonical Notch ligand 1 (DLK1) is a gene that is highly upregulated in all three germ layers during the development of the human body, but is almost absent in end-stage heart failure. This work confirmed ... -
Monozentrische Evaluation der ACR/EULAR-Myositis-Klassifikation 2017
(2025-06-27)This retrospective, single-center study evaluates the applicability and diagnostic accuracy of the 2017 ACR/EULAR classification criteria for idiopathic inflammatory myopathies (IIM), comparing it to previous established ... -
Charakterisierung einer unbekannten Interaktionsregion im Aminoterminus des Transkriptionsfaktors STAT1
(2025-06-26)This study investigates the roles of two amino acid residues, H58 and R70, in the N-terminal domain of the signal transducer and activator of transcription 1 (STAT1) in the context of JAK-STAT pathway activation following ... -
Vorhersagbarkeit der postoperativen Zielrefraktion bei kombinierter Katarakt- und Netzhautoperation
(2025-06-24)With increasing age, the prevalence of lens opacification (cataract) rises, as does the number of vitreoretinal diseases that can be treated with vitreoretinal surgery (vitrectomy). In phakic patients, vitrectomy accelerates ... -
Systematische Recherche und Bewertung von Krankenhausnavigatoren in Deutschland hinsichtlich ihrer Vergleichbarkeit anhand von operativen Ergebnissen und Patientenzufriedenheit am Beispiel der radikalen Prostatovesikulektomie
(2025-06-24)Background: Hospital navigation tools provide online information about treatment quality and patient satisfaction, but their comparability and methodological robustness remain unclear. Objective: This study aimed to ... -
Fluorespirometrische Charakterisierung mitochondrialer Dysfunktion der Hirnregionen Cortex und Hippocampus eines Mausmodells für das Rett-Syndrom
(2025-06-24)Rett syndrome, typically caused by mutations in Methyl-CpG-binding protein 2 (Mecp2), is a severe neurodevelopmental disorder. Mitochondrial dysfunction is implicated as a significant factor in its pathogenesis. This study ... -
The role of CXCR4 in endothelial-to-mesenchymal transition and cardiac fibrosis
(2025-06-24)Cardiac fibrosis contributes critically to the deterioration of heart function in numerous cardiovascular disorders by disrupting normal tissue structure and compliance,which characterized by excessive extracellular matrix ... -
Modulation der zytosolischen Redox-Balance durch aktivitätsinduzierte Ca2+-Signale in hippokampalen Neuronen der Maus
(2025-06-24)Intracellular Ca2+ signals are essential for the modulation of cellular activity and excitability but also represent critical components of cellular dysfunction and damage in various neurological disorders. The aim of this ... -
Zerebrale Kartierung der neuronalen Redox-Veränderung in einem Maus-Modell für das Rett-Syndrom
(2025-06-24)As part of this study, changes in the neuronal redox balance in the brains of Rett mice are mapped and correlated with the progression of Rett syndrome. Fluorescence microscopy techniques (primarily ratiometric CCD camera ... -
Funktionelles Apoptose-Profiling zur Weiterentwicklung zielgerichteter Therapien für die adulte T-Zell akute lymphatische Leukämie (T-ALL)
(2025-06-23)T-cell acute lymphoblastic leukaemia is a very aggressive haematological neoplasia characterised by malignantly transformed precursor T-lymphocytes. Considering the poor prognosis and limited treatment options for affected ... -
Einschränkungen und unfallbedingte Dauer der Arbeitsunfähigkeit / der beruflichen Tätigkeit nach Wirbelsäulenverletzung
(2025-06-23)The traumatic vertebral fracture is a common injury in trauma surgery, that is most often related to men in employable age. So far there are only a few statements regarding the duration of incapacity to work, which the ...