Human- und Zahnmedizin
Recent Submissions
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Die Rolle von ERK1/2 im Prozess des kardialen Remodelings während chronischer Volumenbelastung
(2023-11-23)Chronic heart failure is a disease of great socio-economic importance due to its high prevalence, reduced quality of life, poor prognosis and high healthcare costs. The causes of heart failure include hemodynamic stressors, ... -
Etablierung einer spezifischen Färbung in der röntgenbasierten virtuellen Histologie von Lungenkarzinomen durch den Einsatz goldmarkierter Antikörper
(2023-11-22)Lung cancer is the leading cause for cancer related deaths worldwide. Since the different subtypes can vary considerably in prognosis and available therapeutic options, a precise histopathological diagnosis is essential. ... -
Eine vergleichende Studie der mikrobiellen Hautflora und der bakteriellen Ursachen von Durchfall bei Kindern in städtischen und ländlichen Gemeinden in Indonesien
(2023-11-17)Dieser Arbeit ist die Hypothese vorausgesetzt, dass in Indonesien Enterobacteriaceae einschließlich obligater Krankheitserreger wie Salmonellen, Shigellen und Yersinien bei Kindern, die auf dem Land leben, häufiger vorkommen ... -
Genetische Ursachen syndromaler und nicht-syndromaler Formen der Lippen-Kiefer-Gaumenspalte und funktionelle Analyse möglicher Kandidatengene
(2023-11-17)Oro- and craniofacial malformations comprise a heterogeneous group of congenital developmental disorders of the face and/or skull. Oro- and craniofacial malformations can present in different forms, and can occur as both, ... -
Cytoskeletal assembly in axonal outgrowth and regeneration analyzed using STED microscopy
(2023-11-17)The cytoskeleton is essential for axon outgrowth and regeneration. It must be able to tolerate mechanical force and torsion while also allowing for adaptation and response to trauma or injury, such as axonal lesions. Recent ... -
Prospektive Untersuchung, liquoranalytische Aspekte und Evaluation präanalytischer Bedingungen der CXCL13-Analytik bei Patienten mit akuter Neuroborreliose
(2023-11-17)From July 2014 to August 2019, we examined the clinical characteristics and CSF findings of 72 patients (64 adults, 8 children) with neuroborreliosis as part of a prospective study. According to the modified DGN criteria, ... -
Verbessert eine COVID-19-Impfung die soziale Teilhabe immunsupprimierter Personen?
(2023-11-13)Background. The COVID-19 pandemic has affected the organisation of daily life in many ways. In particular, people with a high risk of severe disease progression, such as immunocompromised people, may have experienced major ... -
Einfluss des Optifast-52-Programms auf den Leberfibrosegrad von Patienten mit Adipositas
(2023-11-13)Non-alcoholic fatty liver disease is the most common liver disease in the industrialized world, which can progress to non-alcoholic steatohepatitis, liver cirrhosis, and hepatocellular carcinoma. In the context of ... -
Das Alter als Verteilungskriterium in der medizinischen humanitären Hilfe
(2023-11-13)Setting priorities in medical humanitarian aid is one of the most pressing issues in this context of particular scarce resources. It is questionable which criteria can be used in case of inescapable allocation decisions ... -
CT-basierte Radiomic Feature Analyse zur Unterscheidung von malignen und benignen Nierentumoren
(2023-11-10)The renal cell carcinoma is the most common malignant tumor of the kidney, with approximately 15,000 new cases per year in Germany. The incidence of small kidney tumors with often benign characteristics has been increasing ... -
Inhibitorische Effekte von 1-Hydroxychinolonen auf Toxoplasma gondii
(2023-11-09)Within the mitochondria of Toxoplasma gondii, 1-hydroxyquinolones were identified as affine inhibitors of the alternative NADH-dehydrogenase at the first complex of the respiratory chain. Another target structure of the ... -
Characterisation of human ribosome assembly factors
(2023-11-09)Ribosomes are highly conserved ribonucleoprotein complexes for translating the genetic code encoded in mRNAs into functional proteins. In consist of a small and large subunit containing ribosomal RNAs as well as ribosomal ... -
Die Beeinflussung des kanonischen Wnt-Signalwegs und ihre Auswirkungen auf die Radio- und Radiochemotherapieresistenz des Ösophaguskarzinoms
(2023-11-09)Esophageal cancer is the eighth most common tumor entity with an increase in prevalence. Possible treatment regimens include radical surgery and/or radio(chemo)therapy. Latter is especially important for locally advanced ... -
MicroRNAs, p16- und HPV-Status und transorale Lasermikrochirurgie im multimodalen Behandlungskonzept bei Oropharynxkarzinomen
(2023-11-08)Carcinomas of the head and neck region are worldwide among the most common malignant diseases. Of these, around 12 - 14% are oropharyngeal carcinomas. Transoral CO2-laser microsurgery is a less invasive procedure, which ... -
Schwannzell-Remyelinisierung bei Neuromyelitis optica
(2023-11-07)Neuromyelitis optica (NMO) is a chronic, autoimmune inflammatory, astrocyte depleting and demyelinating disease of the central nervous system (CNS) and typically affects the spinal cord (myelitis) and optic nerves (neuritis ... -
Molecular Basis of Mitochondrial Diseases Exemplified by Mutation of the Translation Factor Cox14
(2023-11-07)Mitochondrial oxidative phosphorylation (OXPHOS) fuels cellular ATP demands. OXPHOS defects lead to severe human disorders with unexplained tissue specific pathologies. More and more evidence shows that mitochondrial ... -
Untersuchungen zum Einfluss von Nikotinsäure auf Adipozytenhormone und Entzündungsparameter bei Patienten/Patientinnen mit metabolischem Syndrom
(2023-11-03)The present exploratory descriptive study essentially served the purpose of generating hypotheses. The starting point for the considerations was that the anti-atherosclerotic effect of niacin could be attributed to an ... -
Molekular-zytogenetisches Monitoring aus dem peripheren Blut bei Hoch-Risiko-MDS Patienten unter Therapie mit Azacitidin
(2023-11-03)In myelodysplastic syndromes (MDS) pathogenesis, diagnosis, prognosis and also therapy are significantly influenced by chromosomal aberrations. In this retrospective analysis of 76 high-risk MDS patients treated with ... -
Hypoxic Microglial Extracellular Vesicles Abrogate Poststroke AQP4 Depolarization, Astrogliosis and Neuroinflammation
(2023-11-03)Reactive astrogliosis, aquaporin 4 (AQP4) depolarization and neuroinflammation occurring and lasting for a long time in the periinfarct region are associated with poststroke brain injury. Our previous work has revealed ... -
Radio(chemo)therapie bei älteren Patient:innen mit Kopf-Hals-Tumoren – eine retrospektive Untersuchung zur Erfassung von Einflussfaktoren auf Überleben und Toxizität
(2023-11-02)Locally advanced head and neck squamous cell carcinoma (HNSCC) is often treated with surgery followed by postoperative radiochemotherapy (RCT). With the general increase in life expectancy, the number of elderly HNSCC ...