Human- und Zahnmedizin
Recent Submissions
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Eine randomisierte, verblindete, placebokontrollierte prä-klinische Studie zur antifibrotischen und nephroprotektiven Wirkung einer Kombinationstherapie mit dem monoklonalen Antikörper Actinab und dem ACE-Inhibitor Ramipril am Alport-Mausmodell
(2026-01-08)Alport syndrome is a hereditary disorder of type IV collagen that leads to impaired glomerular filtration function in the kidneys. The current standard treatment is early administration of an ACE inhibitor. In this study, ... -
Multimorbidität als Prädiktor für eine stationäre Aufnahme in der klinischen Notfall- und Akutmedizin
(2026-01-08)Background Parallel to demographic trends, an increase of multimorbid patients in emergency and acute medicine is prominent. To define easily applicable criteria for the necessity of inpatient admission, a hierarchical ... -
Vorstellungen guten Lebens von Erwachsenen mit chronischen Herzerkrankungen
(2026-01-06)Background: Quality of life is established in medicine as one of three legally defined endpoints and is typically assessed from the patient’s perspective across physical, psychological, and social dimensions. However, this ... -
Ätiologie und Häufigkeit pathologischer Veränderungen an den Skeletfunden der neolithischen Population aus Völlinghausen
(2026-01-06)Palaeopathology is an interdisciplinary field situated at the interface of (dental) medicine, anthropology, and archaeology. As the only contemporary witnesses, human remains serve as primary sources in the sense of ... -
Die Bedeutung des C-reaktiven Proteins in der Diagnostik von postoperativen periprothetischen Infektionen nach Primärimplantation von Hüftgelenksendoprothesen
(2026-01-06)The primary objective of this doctoral thesis was to develop a cost-efficient diagnostic tool for the detection of postoperative periprosthetic joint infection (PJI) following primary total hip arthroplasty (THA). Additionally, ... -
Durchführbarkeit und Wirksamkeit eines kollaborativen Behandlungsansatzes in der Sekundärprävention der Koronaren Herzerkrankung
(2026-01-06)Adequate management of cardiovascular risk factors (RFs) is important in the secondary prevention of coronary heart disease (CHD), but in practice it is often not easy to achieve. In the USA, the blended collaborative care ... -
Langfristiger Effekt einer Lungenarterienembolie auf das Mortalitätsrisiko
(2026-01-06)While numerous studies have investigated short-term outcomes after pulmonary embolism (PE), long-term mortality remains insufficiently studied. The objectives were investigate long-term outcomes in an unselected cohort of ... -
Einfluss der Aminosäure Phenylalanin an Position 244 des organischen Kationentransporters OCT1 auf die Transportaktivität
(2026-01-06)Membrane transporter proteins such as OCT1 from the SLC family are important for the distribution and homeostasis of drugs and endogenous substances in tissues. OCT1 is known for its polyspecificity, transporting at least ... -
Prä- und Posthomogenisierungsfärbung mit Antikörpern und Nanokörpern bei X10heat-Expansionsmikroskopie
(2026-01-06)Background: Conventional light microscopy is constrained by the diffraction limit and cannot resolve structures smaller than ~200 nm. Super-resolution microscopy (SRM) techniques such as STED, STORM, PALM, and SIM overcome ... -
Validierung einer deutschen Version des Central Sensitization Inventory (CSI-GE)
(2026-01-06)Central sensitization is considered an important factor in the development and maintenance of various chronic pain syndromes. Quantifying this process is challenging. The Central Sensitization Inventory (CSI) was developed ... -
Diagnostische Leistungsfähigkeit nichtinvasiver Pränataltests zur Bestimmung fetaler Merkmale des Rh-Blutgruppensystems
(2026-01-06)Over the past approximately 25 years, analysis of cell-free fetal DNA (cffDNA) from maternal plasma has enabled the non-invasive assessment of genetically determined fetal characteristics. Non-invasive prenatal testing ... -
Häufigkeit der intra- und frühen postoperativen Blutungskomplikationen bei Glaukomoperationen in Abhängigkeit von gerinnungshemmenden Substanzen
(2026-01-06)With the increasing age of the population, the number of patients requiring ophthalmologic care continues to rise. Comorbidities and pre-existing conditions often necessitate treatment with antithrombotic medication, which, ... -
Wissen und Einstellungen von Menschen mit Diabetes mellitus Typ 2 zu ihrer Mundgesundheit (Diabetes mellitus Typ 2 und seine Begleit- und Folgeerkrankungen)
(2025-12-18)BACKGROUND: Type 2 diabetes mellitus (T2DM) and periodontitis are widespread chronic diseases that influence each other bidirectionally and can significantly impair the quality of life of affected individuals. Despite these ... -
Der arrhythmogene Effekt des Knockdowns von kardialem Troponin C auf atriale Kardiomyozyten aus induzierten pluripotenten Stammzellen
(2025-12-18)Atrial fibrillation is the most frequent cardiac arrhythmia; nevertheless, its pathophysiology is still insufficiently understood. Available therapeutic approaches have high recurrence rates, and complications of both ... -
Analyse der simultanen RANKL-Inhibition und OPG-Expressionssteigerung durch Virus-Partikel vermittelte RNA-Interferenz im Ratten-Tiermodell
(2025-12-18)Osteoporosis is characterized by an imbalance in bone metabolism with a predominance of bone resorption, with the RANK–RANKL–OPG signaling pathway controlling osteoclast differentiation. The aim of this work was to establish ... -
Einflussfaktoren auf die Kolonisierung von Clostridioides difficile bei Neugeborenen und Säuglingen – eine epidemiologische Studie
(2025-12-16)An infection with Clostridioides difficile is the most common cause of antibiotic-associated diarrhea in adults worldwide. Due to the increasing incidence of clinically manifest C. difficile infections (CDI), the associated ... -
Welche Rolle spielt SERPINE1/PAI-1 bei der Progression des Zervixkarzinoms?
(2025-12-15)Cervical cancer is the fourth most common cancer in women worldwide. To date, little is known about the G protein-coupled estrogen receptor 1 (GPER1) in cervical cancer. In our working group, Ruckriegl et al. have already ... -
Die Entwicklung und der Verlauf der REM-Schlaf-Verhaltensstörung bei Parkinson-Patienten
(2025-12-15)REM sleep behaviour disorder (RBD) is a parasomnia that occurs predominantly in neurodegenerative diseases such as Parkinson’s disease (PD). Moreover, in individuals with an established diagnosis of PD, RBD is associated ... -
Die Entwicklung des klinischen Outcomes nach Schädel-Hirn-Trauma bei Patienten über 60 Jahren – Ein Vergleich zwischen einer aktuellen Patientenkohorte und einer früheren aus den 80er Jahren
(2025-12-11)With demographic aging, the incidence of traumatic brain injury (TBI) in older adults is increasing significantly. Elderly patients exhibit distinct risk profiles, different trauma mechanisms, and increased vulnerability. ... -
Funktionelle Charakterisierung des organischen-Kationen Protonen Antiporters (H+/OC) und der Kationentransporter MATE1, MATE2-K, OCT1, OCT2, OCT3 und PMAT
(2025-12-10)Approximately 30% of all endogenous substances, as well as many drugs and other biologically relevant molecules, are organic cations. A central aim of this work was to investigate how these positively charged molecules ...