Human- und Zahnmedizin
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Molekulare Charakterisierung von kolorektalen Lebermetastasen mit unterschiedlichen histopathologischen Wachstumsmustern
(2024-12-12)Colorectal cancer liver metastases express different histopathological growth patterns. The three common ones are the replacement, the desmoplastic, and the pushing histopathological growth patterns. Whereas the both latter ... -
Der Einfluss von Raloxifen und Ostarine als Kombinationstherapie aus Östrogen- und Androgenrezeptormodulatoren auf die Knocheneigenschaften bei ovariektomierten Ratten
(2024-12-11)This study combined two pharmacological classes to investigate their preventive effect on the skeletal system of ovariectomised rats. The osteoanabolic properties of SARM Ostarine and the antiresorptive effect of SERM ... -
Die subakuten Effekte des Psilocybin auf Persönlichkeit, Achtsamkeit und die Auflösung des Selbst
(2024-12-10)Psychedelics are a class of drugs that can occasion similar changes in conscious ex- periences mediated via the G-protein coupled Serotonin 2A receptor. These changes vary from slight distortions in perceptions to ... -
Die Evaluierung einer innovativen, multifaktoriellen Formel zur Berechnung der individuellen Erfolgschancen einer Ocriplasmin-(Jetrea®)-Therapie in Augen mit durchgreifendem Makulaforamen
(2024-12-09)The eye, with its ability to see, is one of the most important organs in the human body. It is therefore valuable for life and survival and contributes significantly to the quality of life. With age, the eye also changes ... -
Vergleich der Artikulationsmuster von stotternden und nicht stotternden Probanden anhand der Echtzeit-Magnetresonanz-Tomographie
(2024-12-09)The original neurogenic non-syndromic stuttering begins in early childhood and can persist into adulthood. Its characteristic symptoms are repetition of sounds and syllables, prolongation of sounds, blocking and a variety ... -
Ganganalyse nach Talusfraktur
(2024-12-09)The talus is the bony connection between the lower leg and foot. It articulates with the tibia, fibula, calcaneus and navicular bone and is part of the ankle joint and the subtalar joint. The talus fracture is a rare ... -
Osteoporose bei Mastozytose: Retrospektive Analyse von Betroffenen kutaner oder systemischer Form
(2024-12-09)Mastocytosis is an infiltration of clonal mast cells either in the skin (cutaneous mastocytosis; CM) or at least one extracutaneous organ (systemic mastocytosis; SM). The most frequent systemic subtype is the indolent ... -
Evaluierung des scapholunären Abstandes mittels Echtzeit-MRT
(2024-12-09)The scapholunate interosseous ligament plays a crucial role in maintaining wrist stability, and its dysfunction can lead to instability and progressive joint degeneration. This study investigates the use of real-time MRI ... -
Optogenetic characterization of targeting-optimized Chronos and f-Chrimson variants for auditory encoding in mice
(2024-12-03)Electrical cochlear implants bypass the physiological micromechanics and synaptic sound encoding by sensory hair cells in the cochlea and provide state-of-the-art treatment of sensorineural hearing loss. To overcome the ... -
Role of FOXM1, GPX1, and CCNB1 in cisplatin resistance in malignant thymomas and thymic carcinomas
(2024-12-02)Cisplatin resistance in malignant thymomas and thymic carcinomas remains a significant challenge, impairing therapeutic efficacy and patient outcomes. This study investigates the roles of Glutathione Peroxidase 1 (GPX1), ... -
Die Beteiligung der Transmembranproteine EMMPRIN und Connexin 43 an der Epithelial-Mesenchymalen Transition (EMT) und Metastasierung im oralen Plattenepithelkarzinom
(2024-12-02)Metastasis is a major challenge in the progression of oral squamous cell carcinoma (OSCC) and is closely related to epithelial-mesenchymal transition (EMT) of tumor cells. In the present study, the expression profiles of ... -
Shear Stress and NETosis
(2024-11-29)Neutrophil granulocytes, the most abundant type of circulating immune cells, engage in a process called NETosis when encountering certain pathogens and danger signals or experimentally induced by phorbol-12-myristate-13-acetate ... -
Genetische Polymorphismen im Bereich der Interferon Lambda (IFNL)-Gene und deren prädiktiver Wert für ein Ansprechen auf eine Chemo- oder Radiotherapie bei onkologischen Patienten
(2024-11-29)Chemotherapy and radiotherapy are among the pillars of conventional cancer treatment. The toxic effects of chemotherapeutic agents and the ionizing effects of radiotherapy induce necrosis in neoplastic cells, leading to ... -
Biologische Eigenschaften von circRNA_015350/006696 in Neuronen und Astrozyten unter hypoxischen Bedingungen
(2024-11-29)CircRNAs are a group of non-coding RNAs that have only recently been discovered. Many of the biological functions of circRNAs are not yet fully understood. It is currently assumed that circRNAs can act as miRNA sponges, ... -
Fragebogen zur Evaluation der Körperkonstitution im Rahmen der japanischen Kampo-Medizin
(2024-11-29)Introduction: In traditional Japanese Kampo medicine, a profound anamnesis is completed by clinical examination. The resulting clinical image forms the basis of the patient’s diagnosis pattern, including the recent mental, ... -
Zur Rolle von EZH2 in neuroendokrinen Neoplasien
(2024-11-29)Neuroendocrine neoplasms are rare neoplasms with an increasing incidence, primarily occurring in the gastroenteropancreatic region and the lungs. They are classified into the prognostically more favorable NET and the less ... -
Entwicklung eines zellbasierten Nachweisverfahrens für Serum-anti-Myelin-Oligodendrozyten-Glykoprotein-Antikörper
(2024-11-29)Myelin oligodendrocyte glycoprotein (MOG) is a protein of the outermost layer of the myelin sheath that plays an important role in the pathogenesis of idiopathic demyelinating diseases. The detection of anti-MOG-specific ... -
Rnaset2-Defizienz: Eine klinisch-experimentelle Betrachtung im Kontext der Typ-1-Interferonopathien
(2024-11-28)Rnaset2-deficient cystic leukoencephalopathy is a rare congenital disorder caused by a biallelic loss-of-function mutation. This dissertation consists of a clinical and an experimental part on this disease. Clinically, ... -
Evaluation der sonographisch bestimmten Gallenblasenwanddicke als nicht-invasiver Marker für das Vorliegen eines Leberparenchymumbaus
(2024-11-28)Liver cirrhosis is the final stage of various chronic liver diseases. Causes include chronic alcohol consumption, untreated chronic viral or autoimmune hepatitis, metabolic disorders, and medication, alongside cases with ... -
Impact of the sphingosine-1-phosphate receptor modulator siponimod on functional phenotypes of microglia
(2024-11-26)Over the last decades the number of drugs for the therapy of relapsing remitting multiple sclerosis (RRMS) increased significantly, whereas various approaches to develop an efficient therapy for secondary progressive ...