Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Doenecke, Detlef Prof. Dr."
Now showing items 1-20 of 38
-
Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex
(2015-04-02)In the mammalian sperm tail, the outer dense fibers (ODFs) are accessory fibers accompanying the axonemal tubuli doublets on their outer site. The ODFs are composed of at least 14 polypeptides of which only a few have been ... -
Stage-specific germ cell marker genes function in establishment and germ cell lineage commitment of pluripotent stem cells
(2013-01-15)Germ cells are firmly committed to fulfil the mandate of transmitting genetic and epigenetic information from one generation to the next. Their mysterious characteristics have fascinated biological researchers to study ... -
The influence of post-translational modifications on biology of the linker histone HIS-24 in Caenorhabditis elegans
(2012-06-26)In the eukaryotic nucleus the genome is packaged into a nucleoprotein complex known as chromatin. The chromatin is composed of DNA, core histones (H2A, H2B, H3, H4), linker histones (H1) as well as non-histone proteins. ... -
Funktionelle Charakterisierung der Transkriptionsfaktoren Nkx2.2 und Arx in der Entwicklung der endokrinen Zellen im murinen Pankreas
(2011-09-08)The pancreas is a compound-gland structured into two functional units exhibiting exocrine and endocrine properties. Exocrine cells produce and secret digestive enzymes, whereas endocrine ... -
Crystal structure analysis of selenocysteine biosynthesis components
(2010-11-04)Some organisms from all three domains of life eukaryotes, bacteria and archaea, incorporate selenocysteine (Sec) into fractions of their proteins. Sec synthesis takes place on its ... -
Brain derived neurotrophic factor (BDNF): Untersuchungen zur Expression und Regulation in vitro sowie zur funktionellen Relevanz in der experimentellen autoimmunen Enzephalomyelitis (EAE)
(2010-07-14)The neurotrophin brain derived neurotrophic factor (BDNF) is essential for the development and maintenance of the nervous system. Neurons are the main cellular source of this neurotrophin, ... -
Role of heat shock protein 70 and sulphatases 1 and 2 in apoptosis induced by cytotoxic cells of the immune system
(2009-08-24)Intracellular heat shock protein 70 (HSP70) belongs to the stress response system and can protect cells from different apoptotic stimuli. Extracellular HSP70 on the other hand can activate ... -
Nuclear import of histone fold motif containing heterodimers by importin 13
(2009-08-03)In this study, we have analyzed the nuclear import of two related histone fold pairs, CHRAC-15/17 and p12/CHRAC-17. The CHRAC-15/17 heterodimer is part of the chromatin accessibility complex ... -
SUMOylierung von NFYA
(2009-02-13)Reversible post-translational modification with SUMO (small ubiquitin-related modifier) is an important mechanism to regulate the function, activity or localization of target proteins. ... -
The GRAS Protein SCL14 and TGA Transcription Factors Interact to Regulate Stress-Inducible Promoters
(2008-11-12)This work deals with the identification of signal components involved in plants reaction to xenobiotic substances. The regulatory protein Scarecrow-like 14 (SCL14) was identified as a ... -
Regulation of rat Liver Glucokinase Gene Expression by Sterol Regulatory Element Binding Protein-1a and Forkhead box classO1 Transcription factors
(2008-10-13)Glucokinase (GK) also known as hexokinase IV catalyzes phosphorylation of glucose to glucose-6-phosphate. In contrast to other hexokinases, GK has a low affinity for glucose, is not ... -
Neuroaxonale Schädigung in experimentellen Modellen der multiplen Sklerose
(2008-08-28)Multiple sclerosis (MS) is the commonest non-traumatic neurological disease leading to permanent disability in young adults and is considered to be autoimmune in nature. The hallmarks ... -
CaMKII-dependent regulation of ion channels and its role in cardiac arrhythmias
(2008-07-24)Intracellular calcium (Ca2+) is a central second messenger, which translates the electrical signal into cardiac contraction. This process is termed excitation-contraction coupling (E-C ... -
Expressionsanalyse des humanen Histonsubtyps H1x
(2008-06-02)Nuclear eukaryotic DNA is organised as chromatin in conjunction with proteins. The basal structural organisation unit of chromatin is the nucleosome consisting of the nucleosome core particle, ... -
Functional analysis of IGFBP-2 overexpression in mouse liver myofibroblasts: Therapeutic implication for liver fibrogenesis
(2008-05-20)Liver fibrosis is characterized by abnormal accumulation of extracellular matrix (ECM) proteins which are secreted from the cells of the fibroblast lineage during chronic liver injury. Different liver cell populations ... -
Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration
(2008-04-30)The hallmark of Parkinson's disease (PD) is the loss of dopaminergic (DA) neurons in the substantia nigra (SN), the depletion of striatal dopamine levels, and the presence of intraneuronal proteinaceous cytoplasmatic ... -
Role of intestinal epithelium in inflammatory bowel disease: effect of cytokines and glucocorticoids on CXCL8 and CXCL10 gene expression and NF-kB signalling in intestinal epithelial cell lines
(2008-04-24)Activation of intestinal epithelial cells (IEC) may occur either by luminal antigens stimulation or by inflammatory signals deriving from immune cells in the close vicinity. Production of chemokines by the intestinal ... -
Characterization of cytoplasmic bodies involved in 5' to 3' mRNA degradation in human cells
(2008-04-23)In the context of gene expression regulation, discontinuing translation of mRNAs occurs by evolutionarily conserved mechanisms whose executors have been described to be associated with various types of cytoplasmic ... -
Molecular mechanisms of myelin membrane biogenesis
(2008-03-26)During vertebrate brain development, axons are ensheathed by myelin, an insulating membrane generated by oligodendrocytes. Our aim is to elucidate the cellular machinery that is required for the formation of this membrane. ...