Blättern Fakultät für Biologie und Psychologie (inkl. GAUSS) nach "Braus, Gerhard Prof. Dr." Betreuer
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Regulation of gene expression and adhesion in <i>Saccharomyces cerevisiae</i>
(2005-11-16)Adherence represents one important and initial virulence factor of fungal pathogenicity. In the model fungus Saccharomyces cerevisiae adherence to substrates or to other cells ... -
Regulation of septum formation by RHO4 GTPase signalling in Neurospora crassa
(2010-07-20)Cytokinesis, the process in which a single cell is separated into two daughter cells, is highly conserved from plants to fungi and animals. Consistent with being key regulators of many ... -
Regulation of the anaphase promoting complex (APC/C) in the mitotic and meiotic cell cycle of Saccharomyces cerevisiae
(2004-02-26)Ubiquitin-dependent proteolysis is a crucial process in the eukaryotic cell cycle. A key player of this system is a large complex termed the anaphase promoting complex/cyclosome (APC/C). The APC/C is an ubiquitin ligase, ... -
Regulators of Ubiquitin Dependent Protein Degradation in the Filamentous Fungus <i>Aspergillus nidulans</i>: Insights into CsnB, DenA and CandA Function
(2008-02-21)Ubiquitin dependent protein degradation is a central mechanism regulating multiple functions in cells. Ubiquitination of target proteins requires an enzyme cascade including ubiquitin ligases (E3s). One group of E3s ... -
Role of Gcn4p in nutrient-controlled gene expression in Saccharomyces cerevisiae
(2002-05-08)Under amino acid starvation conditions, the bakers" yeast Saccharomyces cerevisiae activates a system called "General control of amino acid biosynthesis". Gcn4p, the transcription factor ... -
Roles of the Cpc1 regulator of the cross-pathway control in the Verticillium plant pathogens
(2014-06-20)Verticillium longisporum is a soil-borne fungal pathogen of oilseed rape (Brassica napus). Infection is initiated by hyphae from germinating microsclerotia which invade the plant vascular system through penetration of the ... -
Secondary metabolism and development in the filamentous fungus <i>Aspergillus nidulans</i> - Activation of silent gene clusters and characterization of the SAM synthetase SasA
(2012-12-07)Antimicrobial resistance is spreading whereas the number of newly discovered antibiotics is declining. The genomes of filamentous fungi comprise numerous putative gene clusters coding for biosynthetic enzymes of structurally ... -
Specific ubiquitin-dependent protein degradation requires a trimeric CandA complex in Aspergillus nidulans
(2019-05-20)E3 cullin-RING ubiquitin ligase complexes are activated by modification of their cullin scaffold protein with the ubiquitin-like modifier Nedd8. Deneddylases as the COP9 signalosome (CSN) or Den1/A interact and destabilize ... -
Stability regulation of Gcn4p in Saccharomyces cerevisiae
(2006-05-16)Selective rapid protein degradation is an important mechanism for distinct biological events, including cell cycle progression, signal-transduction, and differentiation. Thus, the stability ... -
Stress Response SCF Ubiquitin Ligase F box Protein Fbx15 Controls Nuclear Co repressor Localization and Virulence of the Opportunistic Human Fungal Pathogen Aspergillus fumigatus
(2016-09-06)Aspergillus fumigatus is the most prevalent cause for pulmonary infections in immuno-compromised patients. Virulence factors are often linked to developmental control mechanisms, which are often identified in the closely ... -
Study of genes of the phytopathogenic fungus Verticillium longisporum involved in the colonization of xylem vessels of its host Brassica napus
(2009-04-22)Verticillium longisporum is a devastating soil - borne fungal pathogen of the rapeseed (Brassica napus). It colonizes the xylem vessels of the host plants but the nutritional status ... -
The role of Pcl5p and Pcl7p in the Gcn4p stability regulation of Saccharomyces cerevisiae
(2011-05-09)In the baker s yeast Saccharomyces cerevisiae, the transcriptional activator Gcn4p is the central element of the general amino acid control network that induces more than 500 genes in ... -
The sumoylation and neddylation networks in Aspergillus nidulans development
(2013-10-22)Proteins can be post-translationally modified by the attachment of members of the ubiquitin-like protein family which requires the action of three enzymatic steps. The protein becomes activated by an E1 enzyme, transferred ... -
The tyrosine regulated DAHP synthase and the biosynthetic pathway of aromatic amino acids in Saccharomyces cerevisiae
(2006-10-30)3-Deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) synthases (EC 2.5.1.54) catalyze the initial reaction of the aromatic amino acid biosynthetic pathway. Phosphoenolpyruvate (PEP) and ... -
The velvet protein Vel1 controls initial plant root colonization and conidia formation for xylem distribution in Verticillium wilt
(2021-08-24)The velvet family of regulatory proteins is well-conserved in fungi and links developmental processes and secondary metabolite production. These proteins comprise a velvet domain for DNA binding and dimerization with ... -
Transcriptional Regulation and Differentiation in Saccharomyces and Aspergillus: jlbA, RPS26, and ARO3/4
(2003-12-19)Increasing data from genomics research revealed that the number of isogenes present within a given organism is significantly higher than anticipated a decade ago. Here we have characterised representatives of isogenes, ... -
Translational control by the ribosomal protein Asc1p/Cpc2p in Saccharomyces cerevisiae
(2011-04-14)The mRNA-specific control of translation is of great importance for the adjustment to environmental changes, as e.g. amino acid limitations. It is especially mediated through the mRNA-5 ... -
Verticillium dahliae transcription factors Som1 and Vta3 control microsclerotia formation and sequential steps of plant root penetration and colonisation to induce disease
(2018-10-12)Verticillium dahliae belongs to the soil-borne ascomycete fungi. It causes wilt diseases and early senescence in more than 200 plant species including economically important crops. It can exist in the soil without a host ... -
Yeast Chorismate Mutase: Molecular Evolution of an Allosteric Enzyme
(2003-01-30)Chorismate mutase (CM, EC 5.4.99.5), encoded by ARO7, catalyzes the Claisen rearrangement of chorismate to prephenate in the biosynthesis of the amino acids tyrosine and phenylalanine. The ... -
α-synuclein in Saccharomyces cerevisiae: model for aggregate clearance, cell survival and influence of autophagy
(2012-06-26)α-synuclein is a neuronal protein involved in several neurodegenerative disorders, including Parkinson's Disease (PD). Misfolding and accumulation of α-synuclein into cytoplasmic inclusions correlate with the pathogenesis ...