Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Doenecke, Detlef Prof. Dr."
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Patterns of post-translational histone modifications, chromatin condensation and DNA fragmentation during apoptosis
(2006-04-11)Cell shrinkage, formation of apoptotic bodies and chromatin fragmentation through cleavage of nucleosomal DNA into different fragment sizes catalysed by the DNase CAD (DFF40) are hallmarks ... -
Pharmakologische Untersuchungen zu endokrinen Effekten des UV-Filters Ethylhexyl-methoxycinnamat
(2006-05-31)During the last years it has become apparent that an increased exposure to UV-irradiation is accompanied by noxious side effects. Ethylhexyl-methoxycinnamate (OMC), a cinnamate derivative, ... -
Die Regulation der humanen H3-Histongene
(2003-11-14)The intention of the present thesis was to elucidate the transcriptional regulation of the 11 replication-dependent histone H3 genes and to investigate relationships to the in vivo ... -
Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
(2007-05-23)Under physiological conditions, mitochondrial morphology dynamically shifts between a punctuate appearance and tubular networks by fission and fusion events. Mitochondrial apoptosis pathways ... -
Regulation of rat Liver Glucokinase Gene Expression by Sterol Regulatory Element Binding Protein-1a and Forkhead box classO1 Transcription factors
(2008-10-13)Glucokinase (GK) also known as hexokinase IV catalyzes phosphorylation of glucose to glucose-6-phosphate. In contrast to other hexokinases, GK has a low affinity for glucose, is not ... -
Role of heat shock protein 70 and sulphatases 1 and 2 in apoptosis induced by cytotoxic cells of the immune system
(2009-08-24)Intracellular heat shock protein 70 (HSP70) belongs to the stress response system and can protect cells from different apoptotic stimuli. Extracellular HSP70 on the other hand can activate ... -
Role of intestinal epithelium in inflammatory bowel disease: effect of cytokines and glucocorticoids on CXCL8 and CXCL10 gene expression and NF-kB signalling in intestinal epithelial cell lines
(2008-04-24)Activation of intestinal epithelial cells (IEC) may occur either by luminal antigens stimulation or by inflammatory signals deriving from immune cells in the close vicinity. Production of chemokines by the intestinal ... -
Stage-specific germ cell marker genes function in establishment and germ cell lineage commitment of pluripotent stem cells
(2013-01-15)Germ cells are firmly committed to fulfil the mandate of transmitting genetic and epigenetic information from one generation to the next. Their mysterious characteristics have fascinated biological researchers to study ... -
Studies on the control and function of chromatin fragmentation during apoptosis
(2005-08-10)Apoptosis in eukaryotic cells is often accompanied by chromatin cleavage resulting in nucleosomal fragments. This cleavage is catalyzed by a DNase (named DFF40 or CAD) which is specifically ... -
Subcellular Localization of Nicotiana tabacum TGA Transcription Factors
(2003-02-11)Salicylic acid (SA) is an important signaling molecule in the regulation of plant defense against pathogens. as-1-like cis-elements in the promoters of many defense genes mediate SA- and ... -
SUMOylierung von NFYA
(2009-02-13)Reversible post-translational modification with SUMO (small ubiquitin-related modifier) is an important mechanism to regulate the function, activity or localization of target proteins. ... -
The GRAS Protein SCL14 and TGA Transcription Factors Interact to Regulate Stress-Inducible Promoters
(2008-11-12)This work deals with the identification of signal components involved in plants reaction to xenobiotic substances. The regulatory protein Scarecrow-like 14 (SCL14) was identified as a ... -
The importance of charged amino acids in the human Organic Anion Transporter 1
(2007-02-19)The organic anion transporter 1 (OAT1) is key for the secretion of organic anions in renal proximal tubules. However, not much is currently known about structure-activity relationships ... -
The influence of post-translational modifications on biology of the linker histone HIS-24 in Caenorhabditis elegans
(2012-06-26)In the eukaryotic nucleus the genome is packaged into a nucleoprotein complex known as chromatin. The chromatin is composed of DNA, core histones (H2A, H2B, H3, H4), linker histones (H1) as well as non-histone proteins. ... -
Untersuchung endokriner Effekte von Benzophenon-2 und 17β-Estradiol in estrogen-rezeptiven Organen
(2006-05-31)Hormones control many essential functions of the human body. These messengers are involved in regulating growth, reproductive and metabolic functions, the water-electrolyte balance and the ... -
Untersuchungen zu molekularen Mechanismen der Glucocorticoid-Resistenz bei Akuter Lymphatischer Leukämie (ALL)
(2004-03-10)The initial response to glucocorticoid (GC) in childhood acute lymphoblastic leukemia (ALL) treatment identifies good-(~90% of patients) and poor-responders (~10% of patients) who have a ... -
Zellspezifische Funktionen des Typ 1 Interferonrezeptors bei der experimentellen autoimmunen Enzephalomyelitis
(2007-11-22)Multiple sclerosis (MS) is considered to be an inflammatory demyelinating disease of the central nervous system (CNS), the etiology of which remains unclear. It is generally held that ...