Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Engel, Wolfgang Prof. Dr."
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Impact of iron-deficiency upon behaviour and protein expression in the male mouse with implications for Restless Legs Syndrome
(2009-06-12)Restless legs syndrome (RLS) comprises of both sensory and motor symptoms, observed as an increased pain and periodic jerking movement of the legs. There are two forms of RLS; one ... -
Interference of Toxoplasma gondii with IFN-γ-regulated gene expression of its host cell
(2005-07-11)Toxoplasma gondii is an obligate intracellular parasite that is able to persist within its host for the host s life span. The parasite has evolved multiple strategies in order to establish ... -
Isolation and functional analysis of differentially expressed genes in human prostate cancer
(2003-02-27)Prostate cancer is the most frequently diagnosed solid tumor in men, and the second leading cause of cancer death in males from western countries. One of the key issues in prostate cancer ... -
Die Isolierung und Charakterisierung der cDNA und des Gens Metr-1 der Maus, einem Vertreter der Bruno-like Genfamilie und Analysen zur Expression
(2002-12-13)The BRUNO-like proteins are family members of the RNA Binding proteins. These proteins play an important role in development, cell differentiation and regulation of the nervous system, ... -
miRNA functions in pluripotency and spermatogenesis
(2013-10-23)For quite a long time, non-coding RNAs (ncRNAs) were discriminated and considered as an evolutionary error. In light of this opinion, discovery of small ncRNAs, in particular microRNA (miRNA), which can regulate the gene ... -
Modulation of Gene Expression of Iron Regulatory Proteins, Hemeoxygenase-1 and Lactoferrin, in Mice Liver and Muscle by Different Cytokines, In Two Models of Acute Phase Reaction.
(2010-05-07)Iron is indispensable to living organisms. Iron homeostasis is orchestrated both at the cellular and the systemic level, and liver plays a central role in the regulation of iron ... -
Molecular and Functional Analysis of two Gene Trap Mouse Lines
(2004-05-10)For better understanding of the mechanisms regulating mammalian embryonic development, the isolation and characterization of new genes involved in this mechanism is important. A useful tool ... -
Molecular Characterization of the Male Germ Cell Expressed Genes Hook1 and TSEP22
(2003-12-10)In this work, the two murine genes Hook1 and TSEP22 were characterized at the molecular level. Both genes were expressed in male germ cells and the presence of the gene products of these ... -
Molecular role of Pelota (PELO) in differentiation of embryonic and germ stem cells
(2015-11-05)Pelota (Pelo) is an evolutionary conserved gene, which has been characterized in diverse species. In mouse, Pelo deficiency results in embryonic lethality at early post-implantation stage. The in vitro culture of Pelo-null ... -
Novel interaction partners of the chromatin remodeler CHD7, a protein mutated in CHARGE syndrome
(2012-09-14)Summary CHARGE syndrome, an autosomal dominant inherited multiple malformation syndrome is caused by mutations in the chromodomain helicase DNA binding protein 7 gene (CHD7). In 10% of ‘typical’ CHARGE patients and 40-50% ... -
Phänotypische und molekulare Analyse einer Maus mit Insertionsmutation und axonaler Reorganisation im Hippocampus
(2002-04-23)We generated a new epileptic mouse model showing massive late-onset aberrant mossy fiber sprouting in the adult hippocampus. The mutation of this mouse model derives from an intronic insertion ... -
Physikalische Kartierung der RT1-C/M-Region des Haupthistokompatibilitätskomplexes der Ratte
(2001-10-09)The rat is an important model for studying organ graft rejection and susceptibility to certain complex diseases. The MHC, the RT1 complex, plays a decisive role in controlling these traits. ... -
Pluripotency of multipotent adult germ-line stem cells: analysis of apoptotic and epigenetic features
(2012-05-10)Pluripotency is the potential of cells to proliferate incessantly (self-renewal) and to develop into all cell types of the three germ layers as well as to the germ line. Recently established multipotent adult Germ-line ... -
Promotoranalyse und Expressionsstudien der murinen und humanen fork head homologen Gene Foxq1 und FOXQ1
(2002-02-18)Transcription factors of the fork head gene family play an important role during embryogenesis. The importance of this gene family shows up also in the fact that mutations in different human fork head genes lead to ... -
Die Rolle der IGF-Achse in Kombination mit anderen Wachstumsfaktor-Signalwegen bei der Resistenz oder dem Ansprechen von kolorektalen Karzinomen auf eine Radiochemotherapie
(2013-10-11)In the Western world cancer represents one of the major health problems. Colorectal cancer (CRC) is the third most common tumor incidence. In advanced disease, in most cases a combined radiochemotherapy (RCT) is performed, ... -
Stage-specific germ cell marker genes function in establishment and germ cell lineage commitment of pluripotent stem cells
(2013-01-15)Germ cells are firmly committed to fulfil the mandate of transmitting genetic and epigenetic information from one generation to the next. Their mysterious characteristics have fascinated biological researchers to study ... -
Studies on Expression and Function of Vsig1 Gene
(2011-03-11)The aim of this study was to determine the expression pattern of Vsig1 during testis development and analysis of the conditional Vsig1knockout mouse, transgenic Cyto-Vsig1 and Villin-Vsig1 ... -
Studying synaptopathies using Mecp2 transgenic mouse models
(2013-09-05)The MECP2 gene is located in the Xq28, which encodes for methyl-CpG binding protein 2 (MeCP2). Mutations in MECP2 gene is the primary cause of postnatal neurodevelopmental disorder, Rett syndrome (RTT) (loss-of-function). ... -
The PHD finger protein 5 is a part of the spliceosome and acts as a DNA-binding protein
(2005-12-06)Four proteins namely U2AF35, SRp40, mDomino and Ddx1 were identified as PHF5a interacting partners by using the murine 11.5-days embryo yeast two-hybrid library screening.PHF5a interacting ...