Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Hardeland, Rüdiger Prof. Dr."
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FARINELLI: ein testisspezifisches VAP-Protein und seine Funktion in der Drosophila-Spermatogenese
(2002-08-09)This study focuses on the analysis of a novel gene, farinelli (fan), that is required for male fertility in Drosophila. Even though mRNA and protein are already detected in premeiotic ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Functional analysis of IGFBP-2 overexpression in mouse liver myofibroblasts: Therapeutic implication for liver fibrogenesis
(2008-05-20)Liver fibrosis is characterized by abnormal accumulation of extracellular matrix (ECM) proteins which are secreted from the cells of the fibroblast lineage during chronic liver injury. Different liver cell populations ... -
Funktion des Wind-Proteins in Drosophila melanogaster bei Faltung und/ oder Transport des sekretorischen Proteins Pipe
(2004-07-20)Wind belonging to the PDI-family is located in the ER and is involved in dorso ventral patterning in drosophila. It is responsible for the correct targeting of Pipe, a transmembrane protein ... -
Funktionelle Analysen deregulierter Signalwege transformierter B-Lymphozyten - Das Epstein-Barr-Virus-Onkogen LMP1
(2007-06-20)The development of different tumor entities can often be correlated with a viral infection. One of this tumor associated viruses is the Epstein-Barr virus (EBV). More than 90% of the human ... -
Genetische Variabilität in der phagozytären NAD(P)H-Oxidase: Funktionelle Charakterisierung und Bedeutung für die Zytostatika-Therapie
(2010-01-05)Cardiotoxicity is a severe side effect of doxorubicin-containing chemotherapy as used in the treatment of several tumors and leukemia and up to 6% of treated patients develop congestive ... -
Glucocorticoid receptor signalling and the effect of interleukin 1 beta on glucocorticoid mediated gene expression in intestinal epithelial cell lines Caco-2 and IEC-6
(2000-11-23)Background and aims: It has been reported that epithelial cells are involved in the process of inflammatory bowel disease (IBD) producing proinflammatory cytokines and chemokines. ... -
Größenegulation der Augenanlage von Xenopus laevis durch Inhibition von Hedgehog-, Fgf- und Wnt-Signalen
(2004-01-16)The molecular mechanisms, which underlie the control of organ size during embryogenesis, are only poorly understood. Using the South African clawed frog Xenopus laevis as a ... -
Identifikation und funktionelle Analyse von Xdach1 und Xeya3 als morphogenetische Faktoren der Kopfentwicklung von Xenopus laevis
(2005-02-14)Dachshund (dac) and Eyes absent (eya) are two transcription factors indispensable for proper compound eye development in Drosophila melanogaster. In vertebrates homologues of dac and eya ... -
Identifikation und immunologische Charakterisierung von MHC-Klasse-II-Peptidepitopen in humanen Leukämie- und Lymphom-assoziierten Antigenen
(2006-11-27)CD4+ T cells play important roles in antitumor responses through several different mechanisms. Ultimately, they provide crucial help in the induction and maintenance of CTL responses. ... -
Identifikation von Zielen und molekulare Charakterisierung des RNA-Bindeproteins XSeb4R in Xenopus laevis
(2009-10-28)While developmental processes have been extensively studied in the context of transcriptional regulation, much less is known about regulation via translational regulation. RNA-binding ... -
Identifizierung der für die Agonisten-induzierte Phosphorylierung und Internalisierung relevanten Serine und Threonine in der C-terminalen Domäne des humanen Prostaglandin E2 Rezeptors, Subtyp EP4
(2003-08-18)The prostanoid receptors belong to the family of G protein-coupled receptors with seven transmembrane domains. Four different subtypes have been identified for prostaglandin E2 (PGE2). The ... -
Impact of iron-deficiency upon behaviour and protein expression in the male mouse with implications for Restless Legs Syndrome
(2009-06-12)Restless legs syndrome (RLS) comprises of both sensory and motor symptoms, observed as an increased pain and periodic jerking movement of the legs. There are two forms of RLS; one ... -
Induktion von Apoptose in gynäkologischen Karzinomen <i>in vitro</i> und <i>in vivo</i> durch Antagonisten des Gonadotropin-Releasing Hormons Typ II
(2008-02-22)In human endometrial, ovarian and breast cancers, GnRH-I and GnRH-II and their receptors are parts of a negative autocrine regulatory system of cell proliferation. Based on a tumour-specific signal transduction, GnRH-I ... -
Involvement of N-type voltage dependent calcium channels in axon degeneration during experimental autoimmune optic neuritis
(2007-11-27)Optic neuritis is one of the most common clinical manifestations of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS). After an episode of optic ... -
Involvement of the paired-domain transcription factor Pax6 in the regulation of glucagon gene transcription by insulin
(2000-11-23)Regulation of gene transcription is an important aspect of insulin's action. However, the mechanisms involved are poorly understood. Insulin inhibits glucagon gene transcription and insulin deficiency is associated ... -
Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion
(2005-09-26)This study addresses the significance of the C-terminal phosphorylation sites of CC-chemokine receptor 5 (CCR5) for receptor regulation. β-Arrestin binding and rapid receptor internalization ... -
MHC-Klasse-I-Gene von Weißbüschelaffen (Callithrix jacchus) und deren Expression im Gehirn
(2008-01-17)MHC class I genes and their products are essential components of the adaptive immune response. According to numerous studies it was assumed that neurons do not express MHC class I genes ...