Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Hoyer-Fender, Sigrid Prof. Dr."
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In situ and in vitro analysis of germ and stem cell marker-positive cells in the postnatal ovary of the common marmoset monkey (Callithrix jacchus)
(2014-07-25)Oogonia are the proliferating diploid germ cells within the female gonad giving rise to oocytes. Oocytes are the meiotic female germ cell stages. In humans, almost all oogonia enter meiosis between weeks 9 and 22 of prenatal ... -
Die Isolierung und Charakterisierung der cDNA und des Gens Metr-1 der Maus, einem Vertreter der Bruno-like Genfamilie und Analysen zur Expression
(2002-12-13)The BRUNO-like proteins are family members of the RNA Binding proteins. These proteins play an important role in development, cell differentiation and regulation of the nervous system, ... -
Mammalian spermiogenesis and the formation of the sperm head to tail coupling apparatus
(2021-08-24)The head-tail coupling apparatus (HTCA), also known as connecting piece, provides the physical linkage between the sperm head and its tail. The HTCA morphogenesis initiates during spermiogenesis and is assembled at the ... -
Mechanismen der Durchbrechung der sekundären Antiöstrogenresistenz durch GnRH-Analoga in Mammakarzinomzellen
(2009-11-18)The development of a resistance against the antiproliferative and proapoptotic actions of the antiestrogen tamoxifen is a major clinical problem in the treatment of estrogen receptor positive ... -
miRNA functions in pluripotency and spermatogenesis
(2013-10-23)For quite a long time, non-coding RNAs (ncRNAs) were discriminated and considered as an evolutionary error. In light of this opinion, discovery of small ncRNAs, in particular microRNA (miRNA), which can regulate the gene ... -
Modeling anthracycline-induced cardiotoxicity with patient-specific iPSCs
(2018-04-17)The anthracycline doxorubicin (DOX), one of the most effective chemotherapeutic drugs for the treatment of various cancers, is limited in its clinical applications due to cumulative dose-dependent cardiotoxicity. The ... -
Molecular Characterization of the Male Germ Cell Expressed Genes Hook1 and TSEP22
(2003-12-10)In this work, the two murine genes Hook1 and TSEP22 were characterized at the molecular level. Both genes were expressed in male germ cells and the presence of the gene products of these ... -
Molecular role of Pelota (PELO) in differentiation of embryonic and germ stem cells
(2015-11-05)Pelota (Pelo) is an evolutionary conserved gene, which has been characterized in diverse species. In mouse, Pelo deficiency results in embryonic lethality at early post-implantation stage. The in vitro culture of Pelo-null ... -
Novel interaction partners of the chromatin remodeler CHD7, a protein mutated in CHARGE syndrome
(2012-09-14)Summary CHARGE syndrome, an autosomal dominant inherited multiple malformation syndrome is caused by mutations in the chromodomain helicase DNA binding protein 7 gene (CHD7). In 10% of ‘typical’ CHARGE patients and 40-50% ... -
Pluripotency of multipotent adult germ-line stem cells: analysis of apoptotic and epigenetic features
(2012-05-10)Pluripotency is the potential of cells to proliferate incessantly (self-renewal) and to develop into all cell types of the three germ layers as well as to the germ line. Recently established multipotent adult Germ-line ... -
Polymorphisms in heat shock protein receptors
(2009-10-29)Extracellular heat shock protein 70 (HSP70) can act as an immunological danger signal and stimulate the activity of cytotoxic T lymphocytes and natural killer cells. Therefore, HSP70 is ... -
Rheumatoide Arthritis: Proteomische Analyse von Serum und synovialen Fibroblasten zur Detektion von Biomarkern
(2009-06-23)The rheumatoid arthritis (RA) is a chronic systematic inflammatory disorder that affects primarily the peripheral joints and will lead to a progressive destruction of the articular cartilage ... -
Role of BRD4 and its target Ptp1b in Endothelial cells and in cardiovascular disease models
(2019-03-15)Vascular and lymphatic system is lined by Endothelial cells (ECs) monolayer or endothelium. Healthy endothelium maintains vessel functions by releasing different substances including Nitric Oxide (NO). Cardiovascular risk ... -
Die Rolle der IGF-Achse in Kombination mit anderen Wachstumsfaktor-Signalwegen bei der Resistenz oder dem Ansprechen von kolorektalen Karzinomen auf eine Radiochemotherapie
(2013-10-11)In the Western world cancer represents one of the major health problems. Colorectal cancer (CRC) is the third most common tumor incidence. In advanced disease, in most cases a combined radiochemotherapy (RCT) is performed, ... -
Der Rotmilan (Milvus milvus) im Unteren Eichsfeld.
(2013-11-19)In the present study were examined population density, habitat use and composition, young bird rearing, food and predation on Red Kite (Milvus milvus). Essential questions were how stable is the stock in the area and what ... -
Stage-specific germ cell marker genes function in establishment and germ cell lineage commitment of pluripotent stem cells
(2013-01-15)Germ cells are firmly committed to fulfil the mandate of transmitting genetic and epigenetic information from one generation to the next. Their mysterious characteristics have fascinated biological researchers to study ... -
Studies on Expression and Function of Vsig1 Gene
(2011-03-11)The aim of this study was to determine the expression pattern of Vsig1 during testis development and analysis of the conditional Vsig1knockout mouse, transgenic Cyto-Vsig1 and Villin-Vsig1 ... -
Studying synaptopathies using Mecp2 transgenic mouse models
(2013-09-05)The MECP2 gene is located in the Xq28, which encodes for methyl-CpG binding protein 2 (MeCP2). Mutations in MECP2 gene is the primary cause of postnatal neurodevelopmental disorder, Rett syndrome (RTT) (loss-of-function). ... -
The influence of post-translational modifications on biology of the linker histone HIS-24 in Caenorhabditis elegans
(2012-06-26)In the eukaryotic nucleus the genome is packaged into a nucleoprotein complex known as chromatin. The chromatin is composed of DNA, core histones (H2A, H2B, H3, H4), linker histones (H1) as well as non-histone proteins. ...