Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Jahn, Reinhard Prof. Dr."
Anzeige 21-40 von 41
-
Investigation of the higher order structure of the spliceosomal RNA network
(2007-02-05)Majority of the genes of higher eukaryotes possess introns (internal non-coding sequences) which have to be excised via splicing to generate translatable mRNAs. Recognition and pairing of ... -
Isolation and characterisation of synaptic vesicles from mouse brain
(2011-08-08)All eukaryotic cells exhibit a constant turnover of membrane components via trafficking of vesicles between subcellular compartments. A classical example of a dynamic membrane delimited ... -
Mechanisms of Multivesicular Body Biogenesis and Exosome Release
(2010-06-10)Exosomes are small vesicles with a diameter of approximately 50-100 nm that are secreted by a number of different cells and function in a multitude of intercellular signaling processes. ... -
Modulating the aggregation of alpha-synuclein and prion protein with small molecules.
(2016-11-07)As living and health conditions improve in modern societies, the percentage of older people rises. A byproduct of this ageing is the marked increase of cases of cancer, cardiovascular, and neurodegenerative diseases. Many ... -
N-linked glycosylation of ether á go-go potassium channels: effects on cell surface expression and functional properties
(2004-04-23)Ether á go-go (Eag1) is a voltage gated potassium channel, apparently involved in a broad variety of cellular events. Results from this work show that in rat tissues the Eag1 protein is ... -
Neue Einblicke in die SNARE-vermittelte Fusion: Detektion einzelner Proteoliposomen mit einem konfokalen Mikroskop
(2010-01-15)Neuronal exocytosis is of special interest amongst the multitude of membrane fusion processes taking place in different eukaryotic cells. Understanding the mechanism of fusion between the ... -
On the chloride dependence of vesicular glutamate transport
(2010-06-10)Neurons release neurotransmitters in discrete amounts, the quanta. The transmitters are stored in small membrane-bound organelles, the synaptic vesicles, in the vicinity of the plasma ... -
Regulation and communication between the NRD kinase COT1, the MAK2 MAP kinase and the Striatin complex in Neurospora crassa
(2012-02-22)Establishment and maintenance of cellular polarity are important and fundamental processes in eukaryotes, which have to be coordinated with cell division, differentiation, and cell growth. ... -
Role of the different domains of PSD-95 in basal synaptic transmission
(2011-11-09)Learning and memory has been postulated to rely on changes in synaptic transmission strength. At excitatory synapses in the hippocampus CA1 region, synaptic strength is mainly regulated by ... -
Spatial and temporal aspects of PI(4,5)P<sub>2</sub> and SNAREs in exocytosis studied using isolated membrane sheets and capacitance measurements
(2006-02-09)Ca2+-triggered exocytosis is a highly regulated process and the proteinaceous machinery mediating and regulating it has been studied in detail over the last decade. However, the participation ... -
Structural/functional analysis of synaptotagmin 1 in synaptic transmission using hippocampal autapses
(2005-06-10)Synaptotagmin 1 is a presynaptic vesicular protein, which has been implicated as a putative Ca2+ sensor for fast neurotransmitter release in central nervous system. Structurally, it ... -
Structure and dynamics of the aggregation mechanism of the Parkinson´s disease-associated protein alpha-synuclein
(2006-09-18)In Parkinson s disease (PD), intracellular neuronal inclusions containing amyloid-like aggregates of the protein alpha-synuclein (aS) are deposited in the pigmented nuclei of the brainstem. ... -
Studien zu den biochemischen und strukturellen Eigenschaften von Snapin und zu seiner Rolle in der neuronalen Exozytose
(2005-01-10)Snapin has been originally described by Ilardi et al., 1999 as a brain specific protein that interacts with SNAP-25, one of the central proteins in neuronal exocytosis. Biochemical data on ... -
Subcellular trafficking of proteolipid protein (PLP/DM20) and novel mechanisms of ER retention in Pelizaeus-Merzbacher disease
(2006-11-22)Missense mutations that predict the misfolding of membrane proteins have been associated with a number of neurogenetic diseases. However, it is not known how apparently minor changes in the ... -
Submembrane cytoskeleton-regulated assembly and functional activity of gap junctions
(2004-08-23)Connexins form gap junctions that mediate the transfer of ions, metabolites and second messengers between contacting cells. Many connexin functions, e.g cellular transport, plaque assembly ... -
Synaptic vesicle recycling <i>in Vivo</i>
(2012-03-12)The basic mechanism of neurotransmitter release at synapses is relatively well understood: upon arrival of an action potential, calcium influx into the nerve terminal triggers fusion of ... -
Der Syntaxin 1-Cluster - Organisation und Dynamik einer supramolekularen Struktur der Plasmamembran
(2007-06-27)The plasma membrane of a eukaryotic cell shows much more lateral heterogeneity as would be expected according to the fluid mosaic model proposed by Singer and Nicolson in 1972. Many proteins ... -
Targeting and Anchoring of Munc13-1 and ubMunc13-2 to active zones by RIM1alpha
(2005-11-23)Members of the Unc-13/Munc13 protein family are components of the presynaptic active zone and essential vesicle priming factors in regulated exocytosis. They are thought to mediate vesicle ... -
The timing of the final assembly of the SNARE complex in exocytosis
(2010-01-05)Transfer of information between individual neurons via exocytosis is mediated by fusion of secretory vesicles with the plasma membrane and requires assembly of the SNARE proteins Syntaxin-1, SNAP-25 and Synaptobrevin 2 ... -
Transport Mechanisms of the Vesicular Glutamate Transporter 1
(2013-05-08)In neuronal signal transmission, vesicular neurotransmitter transporters play a key role in quantal size modification. They are filling synaptic vesicles (SVs) with neurotransmitter, fuelled by an electrochemical gradient ...