Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Kramer, Wilfried PD Dr."
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Identification and characterization of Campylobacter jejuni factors relevant for the infection process
(2007-10-09)Campylobacter jejuni is the most frequent bacterial cause of foodborne-illness in the developed world including Germany, where the reported number is 60,000 cases in a year. Despite the ... -
Identification and characterization of virulence associated factors of C. jejuni
(2010-11-25)Campylobacter jejuni, an important food-borne human bacterial pathogen in industrialized countries and in the developing world, the leading cause of bacterial diarrhoea. The infection may ... -
Investigation of the higher order structure of the spliceosomal RNA network
(2007-02-05)Majority of the genes of higher eukaryotes possess introns (internal non-coding sequences) which have to be excised via splicing to generate translatable mRNAs. Recognition and pairing of ... -
Investigations into the mode of action of the DNA uridine endonuclease Mth212 of Methanothermobacter thermautotrophicus ΔH
(2010-03-05)Spontaneous hydrolytic deamination of cytosine to uracil is one of the most frequent DNA modifications during cellular everyday metabolism. To counteract this mutagenic effect, most organisms ... -
Localization and dimerization of the ABC half transporter rAbcb6 as compared to rAbcb7
(2006-07-28)Rat Abcb6 (rAbcb6) is an ABC half transporter of the ABCB subfamily and is expected to require a dimerization partner to perform its function. The main aim of this thesis was to detect a ... -
Localization and Function of RNases in Bacillus subtilis
(2017-03-29)The ability to adapt to changing environmental conditions is essential for every organism to survive. In bacteria, this adaptation relies on the control of the mRNA synthesis, stability, and turnover, which allows the ... -
Molekulare Mechanismen der Regulation der Glukagon-Gentranskription durch die Pax6-Homöodomäne
(2007-06-05)The peptide hormone glucagon increases glucose output from the liver and thus maintains sufficient blood glucose levels during the fasting state. Malfunctions in biosynthesis and secretion ... -
Morphological and molecular adaptation of Aspergillus niger to simulated spaceflight and Mars-like conditions
(2021-10-18)The International Space Station (ISS) is an indoor-closed environment in Low Earth Orbit (LEO). Outside of the ISS, radiation is the most challenging factor outside. In turn, inside the ISS, spaceflight microgravity is the ... -
Ein Netzwerk von heterodimerisierenden C/S1 AtbZIP-Transkriptionsfaktoren und seine Funktion in Seneszenz, Stressantwort und Samenentwicklung
(2006-09-18)Transcription factors of the bZIP (basic region - leucine zipper) family occur in all eukaryotic organisms analyzed so far. bZIP transcription factors bind DNA as dimers, whereby some bZIP ... -
Neue Zugänge zu enantioselektiven lipolytischen Enzymen durch fluoreszenzbasierte Durchmusterung kombinatorischer Bibliotheken
(2008-01-08)This thesis describes the development and evaluation of a high-throughput screening method for the identification and isolation of lipolytic enzyme variants with altered enantioselectivity. ... -
Pharmakogenetik des Zytostatikums Melphalan: Charakterisierung des Membrantransportes
(2009-01-06)Pharmacogenetics deals with genetically determined variation in how individuals respond to drugs. The alkylating agent melphalan - a bis (2-cloroethyl) amino derivative of the amino acid ... -
Piwi and piRNAs act upstream of an endogenous siRNA pathway to suppress Tc3 transposon mobility in the Caenorhabditis elegans germline
(2008-12-16)Several hundred endogenous small RNAs, namely microRNAs (miRNAs), repeat- associated small interfering RNAs (rasiRNAs), small interfering RNAs (siRNAs) have been discovered in diverse ... -
Structure and function of microbial communities involved in biomineralization
(2022-01-27)Different aspects of carbonate precipitation are considered in this study. The first part examines carbonates in a model system that helps to explain the initial steps in the formation of so-called concretions, which are ... -
Studies into the structural basis of the DNA uridine endonuclease activity of exonuclease III homolog Mth212
(2011-05-16)Mth212, an exonuclease III homolog from the archaeon Methanothermobacter thermoautotrophicus, compensates the lack of a DNA uracil glycosylase (UDG) in this organism by catalyzing direct ... -
The complex formation of RNase P and RNase MRP in Saccharomyces cerevisiae
(2024-03-06)Ribonucleoproteins comprise a class of complexes that consist of RNAs and proteins. Riobozymes are catalytically active ribonucleoproteins that play a key role in the maturation of various RNAs. A prominent example is ... -
Transkriptomanalyse der <i>Arabidopsis</i>-Wurzel nach Infektion mit dem pilzlichen Pathogen <i>Verticillium longisporum</i> und Identifizierung von transkriptionellen Regulatoren der Pathogenantwort
(2010-04-08)Verticillium longisporum is a soil-borne fungal pathogen causing vascular disease within a narrow host range of brassica species. It is a mayor pest in oilseed rape cultivation causing ... -
Untersuchung bispezifischer Intradiabodies gegen die Integrine avb3, avb5 und a5b1 auf ihre anti-angiogenen Eigenschaften
(2013-02-21)Angiogenesis, the growth of new blood vessels from preexisting vasculature, is a fundamental process in development, wound repair and reproduction. This process is influenced by growth factors, such as vascular endothelial ... -
Untersuchung der submitochondrialen Verteilung von Oxa1 und Mba1 in Saccharomyces cerevisiae
(2016-04-21)The mitochondria of eucaryotic cells are involved in several cellular processes and fulfill a multitude of fundamental tasks, such as the production of energy via the process of oxidative phosphorylation. They exhibit a ... -
Untersuchungen zur Rolle von Mph1 aus Saccharomyces cerevisiae und seines menschlichen Orthologen FANCM bei der Erhaltung der genomischen Integrität
(2022-07-22)Living is life-threatening. Cells can only endure the diverse exogenous and endogenous attacks on their genome because they are equipped with a network of coordinated security measures: the DNA damage response. Repair ... -
Zur Pluripotenz Spermatogonialer Stammzelllinien
(2008-12-16)Spermatogonial stem celllines isolated and cultivated from adult mouse testis are pluripotent. For further investigation we compared these celllines with pluripotent embryonic stem celllines ...