Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Pöggeler, Stefanie Prof. Dr."
Now showing items 21-40 of 41
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Metagenomics in One Health — from standardization to targeted application
(2020-04-21)This thesis is meant to further the applicability of metagenomics in One Health by discussing key forms of standardization, as well as targeted applications. Metagenomics is a powerful pathogen-agnostic tool, allowing for ... -
Morphological and molecular adaptation of Aspergillus niger to simulated spaceflight and Mars-like conditions
(2021-10-18)The International Space Station (ISS) is an indoor-closed environment in Low Earth Orbit (LEO). Outside of the ISS, radiation is the most challenging factor outside. In turn, inside the ISS, spaceflight microgravity is the ... -
Phosphorylation dependent stability control of the deneddylase DenA and its impact on Aspergillus nidulans development
(2016-04-05)Summary Malfunctioning protein degradation in higher eukaryotes is associated with numerous diseases, including neurodegenerative disorders and cancer. Understanding regulation mechanisms of protein degradation is thus ... -
Phylogenetic and functional diversity of soil prokaryotic communities in temperate deciduous forests with different tree species
(2019-04-30)Forest ecosystems provide an important contribution to global carbon storage through processes mediated by trees. As the dominant forest vegetation, trees largely drive primary productivity and mediate the flow of aboveground ... -
Proteomic investigation of the molecular targets of mycophenolic acid in human cells
(2012-02-14)Mycophenolic acid (MPA) is a potent inhibitor of inosine monophosphate dehydrogenase (IMPDH), a key regulator of purine biosynthesis. MPA is frequently used as an immunosuppressant drug to ... -
Regulation and communication between the NRD kinase COT1, the MAK2 MAP kinase and the Striatin complex in Neurospora crassa
(2012-02-22)Establishment and maintenance of cellular polarity are important and fundamental processes in eukaryotes, which have to be coordinated with cell division, differentiation, and cell growth. ... -
Regulation of fungal polar tip extension through NDR kinase signalling
(2010-07-20)NDR kinases play an important role in cell differentiation and morphogenesis. Until now, not much is known about the regulation of NDR kinases and the cross-communication between individual ... -
Regulation of septum formation by RHO4 GTPase signalling in Neurospora crassa
(2010-07-20)Cytokinesis, the process in which a single cell is separated into two daughter cells, is highly conserved from plants to fungi and animals. Consistent with being key regulators of many ... -
Regulators of Ubiquitin Dependent Protein Degradation in the Filamentous Fungus <i>Aspergillus nidulans</i>: Insights into CsnB, DenA and CandA Function
(2008-02-21)Ubiquitin dependent protein degradation is a central mechanism regulating multiple functions in cells. Ubiquitination of target proteins requires an enzyme cascade including ubiquitin ligases (E3s). One group of E3s ... -
Rho GTPases and their regulators in cell polarity of the filamentous ascomycete Neurospora crassa
(2011-04-07)Rho GTPases are small G proteins of the Ras superfamily that function as molecular switches, activating a variety of effector proteins when in the GTP-bound state and returning to inactivity ... -
Stress Response SCF Ubiquitin Ligase F box Protein Fbx15 Controls Nuclear Co repressor Localization and Virulence of the Opportunistic Human Fungal Pathogen Aspergillus fumigatus
(2016-09-06)Aspergillus fumigatus is the most prevalent cause for pulmonary infections in immuno-compromised patients. Virulence factors are often linked to developmental control mechanisms, which are often identified in the closely ... -
Taxonomic and Functional Characterization of Biopolymer-degrading Microbial Communities in the Intestinal Tract of Beavers
(2019-05-09)The mammalian gut harbors a complex and specialized microbiota, which includes all tree domains of life (Archaea, Bacteria, and Eukarya). Bacteria are the most abundant group within the gut system, and they take part in ... -
The complex formation of RNase P and RNase MRP in Saccharomyces cerevisiae
(2024-03-06)Ribonucleoproteins comprise a class of complexes that consist of RNAs and proteins. Riobozymes are catalytically active ribonucleoproteins that play a key role in the maturation of various RNAs. A prominent example is ... -
The influence of autophagy on the fruiting-body development of the filamentous fungus <i>Sordaria macrospora</i>
(2013-05-17)Autophagy, a tightly controlled degradation process in which a eukaryotic cell digests its own proteins and organelles during starvation or stress, has been shown to be involved in various developmental processes. The ... -
The Molecular Architecture and Structure of the Human Prp19/CDC5L Complex and 35S U5 snRNP
(2011-09-22)Pre-mRNA splicing, the two consecutive transesterification reactions leading to intron removal and exon ligation, is catalyzed by the spliceosome, a highly dynamic, multi-megadalton molecular machinery. The spliceosome is ... -
Translational control by the ribosomal protein Asc1p/Cpc2p in Saccharomyces cerevisiae
(2011-04-14)The mRNA-specific control of translation is of great importance for the adjustment to environmental changes, as e.g. amino acid limitations. It is especially mediated through the mRNA-5 ... -
Untersuchung der Fruchtkörperentwicklung bei dem Hyphenpilz Sordaria macrospora
(2010-12-02)Functional analysis of mammalian striatin-family proteins gain in importance since they are thought to act as central components in calcium-dependent signal transduction pathways, which ... -
Untersuchungen zur antiangiogenen Aktivität des matrizellulären Proteins Thrombospondin-2
(2008-07-21)The formation of new tumor vessels (tumorangiogenesis) is an important mechanism for the growth and progression of tumors. Tumorangiogenesis depends on a complex interplay between pro-and ... -
Verticillium dahliae transcription factors Som1 and Vta3 control microsclerotia formation and sequential steps of plant root penetration and colonisation to induce disease
(2018-10-12)Verticillium dahliae belongs to the soil-borne ascomycete fungi. It causes wilt diseases and early senescence in more than 200 plant species including economically important crops. It can exist in the soil without a host ... -
Zelltyp-spezifische Interaktionen von Toxoplasma gondii und murinen Skelettmuskelzellen in vitro
(2014-06-26)Toxoplasma gondii is one of the most common intracellular protozoan parasites worldwide and an important human pathogen. Its life cycle includes three stages: sporozoites, tachyzoites and bradyzoites. While sporozoites are ...