Dokumente Fakultät für Biologie und Psychologie (inkl. GAUSS) nach Gutachter "Pieler, Tomas Prof. Dr."
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Inhibition of Hox function by the cell cycle regulator geminin
(2004-11-16)In the work, I have shown that murine Geminin associates transiently with members of the Hox-repressing Polycomb complex dependent on the cell cycle, with the chromatin of Hox regulatory ... -
Die Interferenz des Tumorsuppressor-Homologen p63 mit dem kanonischen Wnt-Signalweg
(2010-02-16)The tumor suppressor homologue p63 has an essential role in the proper development of squamous epithelia, limb buds and skin appendages, like hair follicles, teeth and glands. Another ... -
Isolation and Characterization of Human Precatalytic Spliceosomal B Complexes
(2007-04-26)The spliceosomal B complex is the substrate that undergoes catalytic activation leading to catalysis of pre-mRNA splicing. Previous characterization of this complex was performed in the ... -
Ligand induzierte Phosphorylierung des Chemokin Rezeptors CCR5: strukturelle Analyse und Funktion
(2005-09-26)This study addresses the significance of the C-terminal phosphorylation sites of CC-chemokine receptor 5 (CCR5) for receptor regulation. β-Arrestin binding and rapid receptor internalization ... -
miRNA functions in pluripotency and spermatogenesis
(2013-10-23)For quite a long time, non-coding RNAs (ncRNAs) were discriminated and considered as an evolutionary error. In light of this opinion, discovery of small ncRNAs, in particular microRNA (miRNA), which can regulate the gene ... -
Molecular Mechanisms in Primordial Germ Cell Development in Zebrafish
(2007-10-16)In many organisms, primordial germ cells (PGCs) are specified early on in development at distant places from where the gonad will develop. Therefore, the cells have to migrate to reach the ... -
Neuroaxonale Schädigung in experimentellen Modellen der multiplen Sklerose
(2008-08-28)Multiple sclerosis (MS) is the commonest non-traumatic neurological disease leading to permanent disability in young adults and is considered to be autoimmune in nature. The hallmarks ... -
Novel proapoptotic p63 isoforms are driven by an endogenous retrovirus in the male germ line of humans and great apes, likely increasing genome stability
(2011-05-04)TAp63, a homolog of the tumor suppressor p53, has the capability to protect the female germ line by eliminating oocytes that suffered severe DNA damage upon irradiation. Though expression ... -
p53 activity during adenovirus infection
(2010-06-24)Adenovirus is a small DNA tumour virus that has been extensively studied, leading to fundamental discoveries in molecular biology of mammalian cells. In particular, adenovirus oncoproteins ... -
Pancreas Development in <i>Xenopus laevis</i>
(2006-01-02)Previous studies on pancreas development have mainly relied on the use of mouse as a model system in gene targeting experiments. In this study, Xenopus laevis is employed for the analysis ... -
Planar Cell Movements and Axial Patterning During Early Gastrulation of the Rabbit Embryo
(2014-05-22)During mammalian gastrulation cellular mechanisms such as cell movements and cell proliferation give rise to the primitive streak and thereby fix the body axes and create the basis for the ‘milieu intérieur’. Although many ... -
Regulation der Neurogenese durch bHLH-O-Proteine in Xenopus laevis
(2006-12-11)Transcriptional activators and repressors of the bHLH protein family are involved in multiple developmental processes, including the formation of the nervous system in vertebrates and ... -
Die Regulation der Pankreasentwicklung von Xenopus laevis durch Transkriptionsfaktornetzwerke
(2008-12-05)Pancreas development is under control of signalling pathways and a complex transcription factor network. It was previously reported that in Xenopus laevis retinoic acid (RA)- signalling was ... -
Die Rolle des IKK/NF-kappaB Signalweges bei der Myelinisierung, De- und Remyelinisierung des zentralen Nervensystems
(2008-08-27)The present thesis aimed to elucidate the function of the classical NF-kappaB pathway in development (myelination), damage (demyelination) and regeneration (remyelination) of myelin sheaths ... -
Serial Analysis of Gene Expression of Rat Liver Regeneration by Oval Hepatic Stem Cells
(2005-03-18)The liver has the unique capability to regenerate by itself after an injury. Normally adult hepatocytes maintain a perfect balance between cell gain and cell loss and they have the ability ... -
Struktur- und Funktionsanalysen des Pax4-Promotors
(2002-04-05)Pax4 is a member of the Pax family of transcription factors with restricted expression and essentia l functions in the developing pancreas. Pax4 deficient mice do not develop pancreatic ... -
The E2F1-responsive microRNA-449 promotes apoptosis
(2011-07-22)E2F1 is a positive regulator of cell cycle progression and also a potent inducer of apoptosis, especially when activated by DNA damage. To identify E2F1-inducible microRNAs, I performed ... -
The role of microRNA miR-196 in HOX dependant maturation of lumbar motor neurons
(2008-10-08)Small, non-coding microRNAs regulate the translation of many mRNAs through imperfect base pairing in the 3 untranslated region. Three conserved genes, encoding three miR-196 RNAs are ... -
Untersuchungen zu Bedeutung von TGF-β während der Entwicklung des Vorderhirns
(2009-02-18)Transforming Growth Factor βs (TGF-βs) are multifunctional cytokines and mediate a wide range of biological activities in a context dependent manner. TGF-βs and their signalling effectors ... -
Variabilität molekularer axialer Differenzierung am Beginn der Gastrulation beim Kaninchen
(2008-12-10)The development of the body plan within the mammalian embryo is principally affected by the formation of the main body axes; which are anterior-posterior, dorsal-ventral and left-right axes. ...