Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Doenecke, Detlef Prof. Dr."
Now showing items 21-38 of 38
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Zellspezifische Funktionen des Typ 1 Interferonrezeptors bei der experimentellen autoimmunen Enzephalomyelitis
(2007-11-22)Multiple sclerosis (MS) is considered to be an inflammatory demyelinating disease of the central nervous system (CNS), the etiology of which remains unclear. It is generally held that ... -
Nuclear transport of the DNA fragmentation factor via the classical importin α/β-pathway
(2007-11-02)One of the biochemical hallmarks of apoptosis is internucleosomal DNA fragmentation mediated by the endonuclease DNA fragmentation factor (DFF) 40. In proliferating cells DFF40 is expressed ... -
Identification and characterization of Campylobacter jejuni factors relevant for the infection process
(2007-10-09)Campylobacter jejuni is the most frequent bacterial cause of foodborne-illness in the developed world including Germany, where the reported number is 60,000 cases in a year. Despite the ... -
Regulation des mitochondrialen Zerfalls innerhalb der neuronalen Apoptose
(2007-05-23)Under physiological conditions, mitochondrial morphology dynamically shifts between a punctuate appearance and tubular networks by fission and fusion events. Mitochondrial apoptosis pathways ... -
Die Bedeutung der subzellulären CaMKIIδ-Überexpression auf den intrazellulären Ca2+-Stoffwechsel in Herzmuskelzellen
(2007-04-17)The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase. It is formed as a multimer consisting of 6 to 12 monomers. CaMKIIδ, the ... -
The importance of charged amino acids in the human Organic Anion Transporter 1
(2007-02-19)The organic anion transporter 1 (OAT1) is key for the secretion of organic anions in renal proximal tubules. However, not much is currently known about structure-activity relationships ... -
Pharmakologische Untersuchungen zu endokrinen Effekten des UV-Filters Ethylhexyl-methoxycinnamat
(2006-05-31)During the last years it has become apparent that an increased exposure to UV-irradiation is accompanied by noxious side effects. Ethylhexyl-methoxycinnamate (OMC), a cinnamate derivative, ... -
Untersuchung endokriner Effekte von Benzophenon-2 und 17β-Estradiol in estrogen-rezeptiven Organen
(2006-05-31)Hormones control many essential functions of the human body. These messengers are involved in regulating growth, reproductive and metabolic functions, the water-electrolyte balance and the ... -
Patterns of post-translational histone modifications, chromatin condensation and DNA fragmentation during apoptosis
(2006-04-11)Cell shrinkage, formation of apoptotic bodies and chromatin fragmentation through cleavage of nucleosomal DNA into different fragment sizes catalysed by the DNase CAD (DFF40) are hallmarks ... -
Charakterisierung von funktionellen Oberflächenstrukturen des Hepatitis-B-Virus Nukleokapsids
(2005-12-28)During hepatitis B virus (HBV) morphogenesis the transmembrane large envelope protein (L protein) probably directly interacts with mature cytosolic nucleocapsids. The shell of the capsid ... -
Mechanisms underlying the nuclear transport of histones and histone-related proteins
(2005-11-11)The CCAAT-specific transcription factor NF-Y is a heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC. Each subunit contains an evolutionarily conserved core region, comprising a ... -
Studies on the control and function of chromatin fragmentation during apoptosis
(2005-08-10)Apoptosis in eukaryotic cells is often accompanied by chromatin cleavage resulting in nucleosomal fragments. This cleavage is catalyzed by a DNase (named DFF40 or CAD) which is specifically ... -
Local Protein Turnover As a Regulatory Mechanism of Growth and Collapse of Neuronal Growth Cones
(2005-05-11)The axonal growth cone is remarkably sensitive to chemical and mechanical cues from its environment that enables it to make autonomous morphological restructuring decisions. Depending on ... -
Expression and Regulation of the Insulin-like Growth Factor Axis Components in Rat Liver Myofibroblasts
(2004-11-18)Hepatic stellate cells (HSCs) and liver myofibroblasts (LMFs) represent major cell populations involved in liver fibrogenesis. Several lines of evidence demonstrate that in contrast to LMFs, ... -
Untersuchungen zu molekularen Mechanismen der Glucocorticoid-Resistenz bei Akuter Lymphatischer Leukämie (ALL)
(2004-03-10)The initial response to glucocorticoid (GC) in childhood acute lymphoblastic leukemia (ALL) treatment identifies good-(~90% of patients) and poor-responders (~10% of patients) who have a ... -
Neuroligin: Charakterisierung eines neuronalen Transmembranproteins
(2004-02-06)Synapses are highly specialized contact sites where the communication between nerve cells takes place. Cell adhesion proteins are the key regulators of synaptogenesis and modulation. The ... -
Die Regulation der humanen H3-Histongene
(2003-11-14)The intention of the present thesis was to elucidate the transcriptional regulation of the 11 replication-dependent histone H3 genes and to investigate relationships to the in vivo ... -
Subcellular Localization of Nicotiana tabacum TGA Transcription Factors
(2003-02-11)Salicylic acid (SA) is an important signaling molecule in the regulation of plant defense against pathogens. as-1-like cis-elements in the promoters of many defense genes mediate SA- and ...