Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Fritz, Hans-Joachim Prof. Dr."
Now showing items 21-36 of 36
-
Investigation of Protein-protein Interactions within the Human Spliceosomal U4/U6.U5 tri-snRNP Particle
(2005-08-08)Two-hybrid data allowed me to define the regions through which proteins 220K, 200K, and 116K interact with each other. These regions include the N terminal and C-terminal domains of protein ... -
Molecular motions at the 5 stem-loop of U4 snRNA: Implications for U4/U6 snRNP assembly
(2005-07-05)The human 15.5K protein binds to the 5' stem-loop of U4 snRNA (KtU4), promotes the assembly of the spliceosomal U4/U6 snRNP, and is required for the recruitment of the 61K protein and ... -
Identifizierung und Charakterisierung von Genen für die Entwicklung des cerebralen Cortex
(2005-02-01)In order to identify new genes showing a regionalized expression in the E16.5 cerebral cortex a microarray expression analysis with 5 different cortex tissues was performed. After computational ... -
The Regulatory Role of Syntaxin 1 N-terminal Conformation in Vesicle Priming and Exocytosis
(2004-12-16)During vesicle priming at the central synapse, Syntaxin 1, together with SNAP25 and Synaptobrevin, assemble into the synaptic SNARE complex. The formation of SNARE complex is thought to ... -
Identification of a new factor essential for vacuolar aminopeptidase I activity.
(2004-12-08)The Saccharomyces cerevisiae vacuolar aminopeptidase I, Ape1p, is transported from the cytoplasm to the vacuole by constitutive autophagocytosis. Ape1p is synthesized as a proform with a ... -
TIP47 is recruited to lipid droplets and important for the organelle biogenesis and function
(2004-09-27)The cytoplasmic protein TIP47 (tail interacting protein of 47kD) was characterized as a cargo selection device for MPRs (mannose 6-phosphate receptors) and supposed to determine MPR transport ... -
Resistenzentwicklung des Humanen Immundefizienzvirus Typ 1 gegen Azidothymidin in Zellkultur
(2004-07-19)AZT resistance is not restricted to the virus but may also develop on the cellular level. We have generated AZT-resistant HIV-1 variants through passages of HIV-1 in human T-cell lines ... -
Characterization of the 95 kDa sperm adhesion protein
(2004-03-04)During the early stages of fertilisation, the interaction between the spermatozoa and the oocyte involves complex mechanism. The events of gamete recognition and binding triggers signal ... -
Generation of Endoplasmic Reticulum Protein 28 (ERp28) Knock Out Mice, and Structural and Functional Analysis of its Drosophila Homologue, Wind
(2004-02-16)My thesis work includes two parts: firstly, generation of a knock out mouse of a gene, ERp28, which encodes a putative endoplasmic reticulum chaperone protein and secondly, the structural ... -
Post-translational generation of Cá-formylglycine in Prokaryotic Sulfatsases by Radical SAM-Proteins
(2004-02-16)Cá-formylglycine is the catalytic residue of sulfatases. FGly is generated by posttranslational modification of a cysteine (pro- and eukaryotes) or serine (prokaryotes) located in a conserved ... -
Charakterisierung der bradyzoitspezifisch exprimierten P-Typ Plasmamembran ATPase TgPMA1 in <i>Toxoplasma</i> <i>gondii</i>
(2003-09-02)Toxoplasma gondii is an obligate intracellular parasite that causes persistent infections in a broad range of warm-blooded vertebrates, including humans. A stage differentiation ... -
Wirkung schwerer Ionen auf strahlenresistente und strahlensensitive Tumorzellen
(2003-03-12)The reasons for the highly variable sensitivity of different cell types and tissues against ionising radiation are still unknown. The increased radiosensitivity was observed at the level ... -
Röntgenstrahlen induzierte DNA- Doppelstrangbrüche in säugen Zellen in Abhängigkeit vom Zellzyklus.
(2002-11-25)The present study reports improvements in the neutral comet assay first introduced by (Singh and Stephans, 1997; Olive et al., 1998) to measure radiation induced DNA damage. Different ... -
Analyse des Transkriptionsfaktors TGA2.1 aus Nicotiana tabacum
(2002-04-02)The thesis explores the possible function of the plant transcription factor TGA2.1. For this purpose genetically modified plants were generated in which a) TGA2.1 was ectopically overexpressed ... -
Charakterisierung eines neuen Proteins, Mapl-1 und seine Rolle in der Regulation der Pax-6 Funktion.
(2002-01-22)Pax proteins comprise a family of highly conserved transcriptional regulators that hold essential roles during embryonic development and organogenesis. The structural motif common to all ...