Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Hardeland, Rüdiger Prof. Dr."
Now showing items 21-40 of 74
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Involvement of N-type voltage dependent calcium channels in axon degeneration during experimental autoimmune optic neuritis
(2007-11-27)Optic neuritis is one of the most common clinical manifestations of multiple sclerosis (MS), a chronic inflammatory disease of the central nervous system (CNS). After an episode of optic ... -
Redoxmodulation Hippokampaler Neurone
(2007-11-19)Mitochondria constantly release various amounts of superoxide anions which are usually rapidly converted to H2O2. Especially disturbance of mitochondrial function can lead to an increased ... -
Nuclear transport of the DNA fragmentation factor via the classical importin α/β-pathway
(2007-11-02)One of the biochemical hallmarks of apoptosis is internucleosomal DNA fragmentation mediated by the endonuclease DNA fragmentation factor (DFF) 40. In proliferating cells DFF40 is expressed ... -
Untersuchungen zur Funktion des RanGAP1 Proteins
(2007-08-07)Beyond its main function in nucleocytoplasmic transport the RanGTPase cycle has been implicated in the regulation of various aspects of mitotic progression. The RanGTPase activating protein ... -
Funktionelle Analysen deregulierter Signalwege transformierter B-Lymphozyten - Das Epstein-Barr-Virus-Onkogen LMP1
(2007-06-20)The development of different tumor entities can often be correlated with a viral infection. One of this tumor associated viruses is the Epstein-Barr virus (EBV). More than 90% of the human ... -
Molekulare Mechanismen der Regulation der Glukagon-Gentranskription durch die Pax6-Homöodomäne
(2007-06-05)The peptide hormone glucagon increases glucose output from the liver and thus maintains sufficient blood glucose levels during the fasting state. Malfunctions in biosynthesis and secretion ... -
Die Bedeutung der subzellulären CaMKIIδ-Überexpression auf den intrazellulären Ca2+-Stoffwechsel in Herzmuskelzellen
(2007-04-17)The Ca2+/calmodulin-dependent protein kinase II (CaMKII) is a multifunctional serine/threonine protein kinase. It is formed as a multimer consisting of 6 to 12 monomers. CaMKIIδ, the ... -
The importance of charged amino acids in the human Organic Anion Transporter 1
(2007-02-19)The organic anion transporter 1 (OAT1) is key for the secretion of organic anions in renal proximal tubules. However, not much is currently known about structure-activity relationships ... -
Einfluss der Helix 1 und des β-Faltblattes auf die Aggregation des Prionproteins und seine Amyloidstruktur
(2007-02-07)Prion diseases are caused by the aggregation of the native α-helical prion protein PrPC into its pathological β-sheet-rich isoform PrPSc. In current models of PrPSc, helix1 is assumed to ... -
Struktur-Funtionsbeziehung in den spleißosomalen Proteinen des U4/U6•U5 tri-snRNP
(2007-01-29)Subject of this thesis is the splicesosmal U5-particle. The functional relationship of the proteins is investigated by means of limited proteolysis and spectroscopy. Due to the splicesosome's ... -
Vergleich der Radikalreaktionen von Melatonin und strukturverwandten Indolaminen in unterschiedlichen Oxidationssystemen.
(2007-01-29)A comparison analysis in structure related Indolamine of Melatonin showed that small changes of Substituenten already draw considerable losses after themselves in oxidation chemistry. ... -
Zur Funktion von Leupaxin beim Karzinom der Prostata
(2006-12-13)Prostate cancer is the most frequent cancer in man and the second leading cause of cancer related deaths in western countries. The cancer first developes as an androgen-dependent lesion, ... -
Identifikation und immunologische Charakterisierung von MHC-Klasse-II-Peptidepitopen in humanen Leukämie- und Lymphom-assoziierten Antigenen
(2006-11-27)CD4+ T cells play important roles in antitumor responses through several different mechanisms. Ultimately, they provide crucial help in the induction and maintenance of CTL responses. ... -
Characterization of foetal hepatic cells during rat liver development
(2006-11-06)During embryonic development the embryonic/foetal liver is the site where hepatogenesis and hematopoiesis take place. Hepatoblasts have been partly characterized in several previous studies. ... -
Untersuchungen zur Expression, Funktion und Regulation ausgewählter Gene der Insulinfamilie
(2006-10-16)In the present study, expression and functional analyses of two novel members of the insulin-superfamily, Insl5 and Insl6, were performed. Northern blot analysis on mRNA extracted from the ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Expression und Funktion von Caveolin bei glialen Zellen, insbesondere Oligodendrozyten
(2006-07-25)Caveolin-containing microdomains (CMD) are subdomains of the plasma membrane that contain high concentrations of sphingomyelin, glycosphingolipids and cholesterol. They are involved in ... -
Eskalierendes Commitment und präferenzkonsistente Informationsbewertung
(2006-07-14)The PhD thesis offers a new explanation for escalation of commitment. Escalation of commitment is the tendency to persist in losing courses of action or to throw good money after bad. ... -
BEHAVIOURAL AND PHARMACOLOGICAL VALIDATION OF CHRONIC SOCIAL STRESS AS A MODEL OF DEPRESSIVE-LIKE SYMPTOMS IN RATS
(2006-06-22)In order to develop a model of chronic social stress in rats, in the first study the male Wistar rats were subjected to five weeks daily exposure to social defeat. This protocol resulted ...