Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Heinrich, Ralf Prof. Dr."
Now showing items 21-40 of 57
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Vocal communication in a tolerant multi-level society: insights from signallers and receivers in Guinea baboons
(2013-07-03)When studying the evolution of animal communication it is important to consider both, the signaller (i.e. signal structure and signal usage) and the receiver (i.e. signal response). While in primates the structure of sounds ... -
Stoichiometric Biology of the Synapse
(2013-05-07)Synaptic transmission at chemical synapses relies on the fusion of neurotransmitter-loaded vesicles with the plasma membrane of the pre-synaptic terminal (exocytosis). The synaptic vesicle material is then retrieved from ... -
Modulation of Histone Deacetylases Attenuates the Pathogenesis of Alzheimer's disease
(2011-04-12)SummaryWe are yet to learn precisely how we learn. The molecular and physiological mechanisms that govern the process of cognition remain a mystery to scientific minds around the globe. ... -
Bilateral processing of thermoreception in the olfactory system of larval Xenopus laevis
(2011-01-12)This study of the ventral olfactory bulb of larval Xenopus laevis shows for the first time the existence of a thermosensitive olfactory glomerulus. This thermosensitive olfactory glomerulus ... -
Die Rolle der Synaptische Kurzzeitplastizität im neuronale Schaltkreise
(2010-12-03)Neuronal microcircuit is built by neurons connected with dynamic synapses. Short-term synaptic plasticity is one form of the synaptic dynamics, which plays various roles in the circuit ... -
Modulatorische Effekte von Stickstoffmonoxid und Juvenilhormon auf die Kontrolle des Reproduktionsverhaltens in weiblichen Chorthippus biguttulus
(2010-11-26)Juvenile hormone (JH) and nitric oxide (NO) both influence the reproductive behavior of female grasshoppers. The present thesis explores a possible connection between JH and NO signaling ... -
The Role of the Ras Guanyl-Nucleotide Exchange Factor Rasgrp1 in Synaptic Transmission
(2010-10-22)Ras signaling pathways are known to regulate neuronal development and function. Ras G proteins have been implicated in the differentiation of neurons, e.g. in dendrite and dendritic spine ... -
Molecular mechanism of Inhibition of the CREB-coactivator TORC by the mitogen-activated kinase DLK in pancreatic beta-cells
(2010-09-08)The ubiquitously expressed transcription factor CREB is involved in numerous cell signalling pathways including metabolic process, cell cycle or survival, cell growth and immune ... -
Neuroprotektion und Neurorestauration im MPTP Modell der Parkinson Erkrankung
(2010-07-01)Parkinson s disease (PD) is the most common neurodegenerative movement disorder of the basal ganglia and is characterized by a progressive loss of dopaminergic neurons in the substantia ... -
Anti-TGF-beta-Antikörper und Öffnung der Blut-Hirn-Schranke - Evaluation neuer Optionen zur Behandlung hochmaligner Gliome im Tiermodell
(2010-06-16)Malignant brain tumors are characterized by a very poor prognosis with current standard-of-care therapies. Even high dose chemotherapy and new experimental drugs have not improved the outcome ... -
Expression and function of erythropoietin and its receptor in invertebrate nervous systems
(2010-02-08)This doctoral study provided substantial evidences for the presence of the EPO/EPOR signalling system in the CNS of invertebrates from different phyla (chapter 2) and demonstrated neuroprotective ... -
Überleben und Differenzierung TAT-Bcl-xL-transduzierter transplantierter neuraler Vorläuferzellen nach zerebraler Ischämie der Maus
(2010-01-06)Increased endogenous neurogenesis can be observed after cerebral ischemia in mice, but fails to significantly contribute to neural regeneration or integration. Therefore, the local application ... -
Induktion und Spezifikation serotonerger Neurone des ventralen Rhombencephalon der Maus
(2009-10-26)The serotonergic (5-HT) system is involved in the modulation of mood and behaviour. Extrinsic factors, such as fibroblast growth factor 4 (Fgf4), Fgf8, and sonic hedghog (Shh), dictate ... -
Studien zur Pathogenese humaner Leukoenzephalopathien
(2009-09-17)Leukoencephalopathies present a group of inborn, mostly neurodegenerative diseases. The aim of this work was to investigate two of these leukoencephalopathies: the GJA12-associated ... -
A new rodent model of Parkinson s Disease based on neuron specific downregulation of glutathione production.
(2009-04-21)Parkinson s disease (PD) is characterized by a progressive degeneration of the nigrostriatal system. Only in few patients genetic mutations have been identified to cause disease onset, ... -
Bilaterale Koordination kommissuraler Interneurone im Mesothorakalganglion von Locusta migratoria migratorioides
(2009-03-26)Bilateral left-right-coordination of insect pairs of legs must involve commissural interneurons (CINs) which cross the midline of the segmental ganglion. This study describes two types ... -
Large Dense Core Vesicle Exocytosis in Mouse Chromaffin Cells is Regulated by Munc13s and Baiap3
(2008-12-16)Members of mammalian uncoordinated 13 protein family (Munc13s) are essential for SV exocytosis in neurons and have also been implicated in LDCV exocytosis in chromaffin cells. However, ... -
Verbesserung kognitiver Leistungen bei chronischer Schizophrenie durch rekombinantes humanes Erythropoietin (rhEPO)
(2008-07-15)Schizophrenia is increasingly recognized as a neurodevelopmental disease with an additional degenerative component, comprising cognitive decline and loss of cortical gray matter. ... -
Cell-penetrating peptide-enhanced delivery of heat shock proteins in models of neurodegeneration
(2008-04-30)The hallmark of Parkinson's disease (PD) is the loss of dopaminergic (DA) neurons in the substantia nigra (SN), the depletion of striatal dopamine levels, and the presence of intraneuronal proteinaceous cytoplasmatic ... -
Induktion von Apoptose in gynäkologischen Karzinomen <i>in vitro</i> und <i>in vivo</i> durch Antagonisten des Gonadotropin-Releasing Hormons Typ II
(2008-02-22)In human endometrial, ovarian and breast cancers, GnRH-I and GnRH-II and their receptors are parts of a negative autocrine regulatory system of cell proliferation. Based on a tumour-specific signal transduction, GnRH-I ...