Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Hoyer-Fender, Sigrid Prof. Dr."
Now showing items 21-40 of 46
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Novel interaction partners of the chromatin remodeler CHD7, a protein mutated in CHARGE syndrome
(2012-09-14)Summary CHARGE syndrome, an autosomal dominant inherited multiple malformation syndrome is caused by mutations in the chromodomain helicase DNA binding protein 7 gene (CHD7). In 10% of ‘typical’ CHARGE patients and 40-50% ... -
The influence of post-translational modifications on biology of the linker histone HIS-24 in Caenorhabditis elegans
(2012-06-26)In the eukaryotic nucleus the genome is packaged into a nucleoprotein complex known as chromatin. The chromatin is composed of DNA, core histones (H2A, H2B, H3, H4), linker histones (H1) as well as non-histone proteins. ... -
Pluripotency of multipotent adult germ-line stem cells: analysis of apoptotic and epigenetic features
(2012-05-10)Pluripotency is the potential of cells to proliferate incessantly (self-renewal) and to develop into all cell types of the three germ layers as well as to the germ line. Recently established multipotent adult Germ-line ... -
Comparative Analysis of Embryonic Stem Cells and Multipotent Adult Germline Stem Cells at the Level of Transcriptome and Proteome
(2011-04-01)Pluripotency of different stem cell types is a complex biological state which allows the cells to continuously proliferate (self-renewal) but also primes them for differentiation into all ... -
Studies on Expression and Function of Vsig1 Gene
(2011-03-11)The aim of this study was to determine the expression pattern of Vsig1 during testis development and analysis of the conditional Vsig1knockout mouse, transgenic Cyto-Vsig1 and Villin-Vsig1 ... -
Differentiation of Flk-1 positive multipotent adult germline stem cells into endothelial cells in vitro and in vivo
(2011-03-08)Multipotent adult germline stem cells (maGSCs) offer a novel route to cell-based therapy without immune rejection and ethical limitations. The present study showed the generation and expansion ... -
Charakterisierung von Leupaxin und seiner Interaktionspartner in Karzinomzellen
(2011-02-23)Leupaxin (LPXN) is identified as a protein enhancing the growth of existing TRAMP-tumours and metastasis. Various pathways give evidence of this effect. The overexpression of LPXN in Prostate ... -
Einfluss von GnRH Analoga auf die Metastasierung humaner Mammakarzinomzellen in vitro und in vivo
(2010-12-08)Breast cancer is one of the tumor diseases with a very strong metastasis behavior, with the bone as one of the main target sites. Since 50 % of human breast cancers express GnRH receptors, ... -
Über die funktionelle Analyse des murinen peroxisomalen Testis-spezifischen Gen 1 (Pxt1)
(2010-11-26)Mammalian spermatogenesis is a complex biological process by which diploid spermatogonia differentiate into specialized haploid spermatozoa. Regulation of male gametogenesis involves a ... -
Effekte von Hypericin auf humane renale Karzinomzellen in vitro
(2010-06-08)Hypericin is an agent extracted from Hypericum plants. St. John s wort (Hypericum perforatum, L.) is the most common representative of this genus. Blooms and leaves of Hypericum plants are ... -
Functional characterization of CDY family proteins and their role in recognition of the heterochromatic histone H3K9me3 modification
(2010-01-14)In the nucleus of eukaryotic cells the DNA is wrapped around octamers of histone proteins containing two H2A-H2B dimers and one (H3-H4)2 tetramer. This entity represents the basic repeating ... -
Functional Analysis of Insl5 and Insl6 Genes and Verification of Interactions between Pelota and its Putative Interacting Proteins.
(2009-11-27)The aims of the study were to determinate expression and function of two members of insulin like family, namely Insl5 and Insl6 and to verify the interactions between PELO and its putative ... -
Mechanismen der Durchbrechung der sekundären Antiöstrogenresistenz durch GnRH-Analoga in Mammakarzinomzellen
(2009-11-18)The development of a resistance against the antiproliferative and proapoptotic actions of the antiestrogen tamoxifen is a major clinical problem in the treatment of estrogen receptor positive ... -
Polymorphisms in heat shock protein receptors
(2009-10-29)Extracellular heat shock protein 70 (HSP70) can act as an immunological danger signal and stimulate the activity of cytotoxic T lymphocytes and natural killer cells. Therefore, HSP70 is ... -
Identifikation und funktionelle Charakterisierung von Effektorproteinen des Typ III Sekretionssystems von Chlamydophila pneumoniae
(2009-09-08)Chlamydophila pneumoniae causes atypical pneumoniae and is also discussed as a risk factor for a wide range of chronic diseases like chronic obstructive pulmonary disease or atherosklerosis. ... -
Rheumatoide Arthritis: Proteomische Analyse von Serum und synovialen Fibroblasten zur Detektion von Biomarkern
(2009-06-23)The rheumatoid arthritis (RA) is a chronic systematic inflammatory disorder that affects primarily the peripheral joints and will lead to a progressive destruction of the articular cartilage ... -
Zur Pluripotenz Spermatogonialer Stammzelllinien
(2008-12-16)Spermatogonial stem celllines isolated and cultivated from adult mouse testis are pluripotent. For further investigation we compared these celllines with pluripotent embryonic stem celllines ... -
Untersuchung Rezeptor-vermittelter Interaktionen zwischen Defensinen und Zellen des Immunsystems
(2008-05-02)Human defensins are natural peptide antibiotics. On the basis of the position and bonding of their six highly conserved cysteine residues, they are divided into two families, designated alpha- und beta-defensins. ... -
Expression and Functional Analysis of the Fas-Associated Factor1 (Faf1) Gene
(2007-04-27)Janchiv, Khulan: Expression and Functional Analysis of the Fas-Associated Factor1 (Faf1) Gene Key words: Faf1, VCP, UBA, UBX, TUNEL Dissertation zur Erlangung des Doktortitels, angenommen ...