Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Jahn, Reinhard Prof. Dr."
Now showing items 21-40 of 42
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Biophysikalische und thermodynamische Charakterisierung der neuronalen SNARE-Komplexbildung
(2008-07-16)Membrane fusion events are mediated by a set of conserved protein machinery, the SNARE proteins. SNARE proteins assemble into a very stable α-helical complex between two membranes. The ... -
Epac-mediated modulation of neurotransmitter release from cultured hippocampal neurons
(2008-07-15)cAMP regulates secretory processes through both protein kinase A (PKA)-independent and PKA-dependent signaling pathways. However, their relative contributions to fast neurotransmission are ... -
Differentielle Expression und Funktion eines glialen Kaliumkanals (K<sub>ir</sub>4.1, KCNJ10) im Rückenmark und Bedeutung in einem neurodegenerativen Krankheitsmodell
(2008-07-10)In the last decade it became more and more obvious, that inwardly-rectifying potassium channels (Kir), beside their classical role in establishing and maintaining the resting membrane ... -
Der Syntaxin 1-Cluster - Organisation und Dynamik einer supramolekularen Struktur der Plasmamembran
(2007-06-27)The plasma membrane of a eukaryotic cell shows much more lateral heterogeneity as would be expected according to the fluid mosaic model proposed by Singer and Nicolson in 1972. Many proteins ... -
Investigation of the higher order structure of the spliceosomal RNA network
(2007-02-05)Majority of the genes of higher eukaryotes possess introns (internal non-coding sequences) which have to be excised via splicing to generate translatable mRNAs. Recognition and pairing of ... -
Evolution of Bicoid-dependent hunchback Regulation in Diptera
(2006-12-20)An early segmentation gene of Drosophila melanogaster, hunchback, with an evolutionarily conserved function but diverging regulation was used as an entry point to explore the evolution of early ... -
Subcellular trafficking of proteolipid protein (PLP/DM20) and novel mechanisms of ER retention in Pelizaeus-Merzbacher disease
(2006-11-22)Missense mutations that predict the misfolding of membrane proteins have been associated with a number of neurogenetic diseases. However, it is not known how apparently minor changes in the ... -
Investigation of Protein - Protein Interactions in Clathrin-Mediated Membrane Transport
(2006-11-13)Ever since it was reported that synaptic vesicle (SV) retrieval follows two kinetic phases, the molecular mechanisms corresponding to these kinetic modes have been controversially discussed. ... -
Functional Studies of SNAP-25 using a knock-out and rescue approach
(2006-11-01)The neuronal SNARE complex, consisting of SNAP-25, synaptobrevin and syntaxin, is required for presynaptic exocytosis of neurotransmitter-filled vesicles during synaptic transmission. However ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Structure and dynamics of the aggregation mechanism of the Parkinson´s disease-associated protein alpha-synuclein
(2006-09-18)In Parkinson s disease (PD), intracellular neuronal inclusions containing amyloid-like aggregates of the protein alpha-synuclein (aS) are deposited in the pigmented nuclei of the brainstem. ... -
Fluoreszenzmikroskopische Studien an Plasmamembranen zur Untersuchung der molekularen Mechanismen der neuronalen Exocytose
(2006-09-18)During regulated exocytosis from neurons and neuroendocrine cells a rise in intracellular calcium concentration leads to the formation of the so-called core-complex, between the plasmalemmal ... -
Development of Viral Tools for CNS Gene Transfer: Adeno-Associated Viral Vectors in Gene Therapy of Parkinson's Disease
(2006-08-09)Gene transfer to the brain is a promising therapeutic strategy for a variety of neurodegenerative disorders including Parkinson s disease (PD). PD is characterized by a progressive degeneration of the nigrostriatal ... -
Spatial and temporal aspects of PI(4,5)P<sub>2</sub> and SNAREs in exocytosis studied using isolated membrane sheets and capacitance measurements
(2006-02-09)Ca2+-triggered exocytosis is a highly regulated process and the proteinaceous machinery mediating and regulating it has been studied in detail over the last decade. However, the participation ... -
Targeting and Anchoring of Munc13-1 and ubMunc13-2 to active zones by RIM1alpha
(2005-11-23)Members of the Unc-13/Munc13 protein family are components of the presynaptic active zone and essential vesicle priming factors in regulated exocytosis. They are thought to mediate vesicle ... -
Elektronenmikroskopische 3D Strukturbestimmung des Spleißosoms
(2005-08-15)In order to elucidate the conformational changes of the spliceosome that occur during its catalytic activation it is necessary to obtain high resolution 3D structures. The 3D structure of ... -
Genetic analysis of stoned B/stonin 2 function in vivo
(2005-07-04)Clathrin-mediated endocytosis at presynaptic nerve terminals is a regulated process tightly coupled to the exocytotic fusion event that requires clathrin, dynamin, AP2 as well as synaptotagmin ... -
Structural/functional analysis of synaptotagmin 1 in synaptic transmission using hippocampal autapses
(2005-06-10)Synaptotagmin 1 is a presynaptic vesicular protein, which has been implicated as a putative Ca2+ sensor for fast neurotransmitter release in central nervous system. Structurally, it ... -
Die Funktionelle Rolle der Palmitilierung des 5-HT 1A Rezeptor
(2005-04-08)In the present study, we verified that the mouse 5-hydroxytryptamine(1A) (5-HT(1A)) receptor is modified by palmitic acid, which is covalently attached to the protein through a thioester-type ... -
Studien zu den biochemischen und strukturellen Eigenschaften von Snapin und zu seiner Rolle in der neuronalen Exozytose
(2005-01-10)Snapin has been originally described by Ilardi et al., 1999 as a brain specific protein that interacts with SNAP-25, one of the central proteins in neuronal exocytosis. Biochemical data on ...