Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Tittmann, Kai Prof. Dr."
Now showing items 21-28 of 28
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Protein interactions along the presequence import pathway
(2014-05-09)In this thesis the mechanisms of protein transport by the translocase of the inner mitochondrial membrane (TIM23) was investigated. Purified presequence peptides containing a p-benzophenyalalanine were established as a ... -
Structural characterization of the minimal human RISC-loading complex
(2014-03-07)Gene expression is the prerequisite for protein biosynthesis in all cells. Rapid and fine-tuned control of gene expression in response to environmental changes is of great importance. A major gene regulation mechanism in ... -
Regulation der Aktivität und Lokalisation von Antiterminatorproteinen der BglG-Familie
(2012-11-12)The regulation of gene expression is essential for all bacteria and allows adapting to changing life conditions. Different transcription and translation factors have an important impact on gene regulation. The antermination ... -
Conformational Sampling of Enzyme dynamics: Triosephosphate Isomerase
(2012-10-17)Triosephosphate Isomerase is a glycolytic enzyme catalyzing the interconversion of Dihydroxyacetone phosphate to Glyceraldehyde-3-phosphate. TIM is a dimer and each monomer is comprised of 249 amino acids. The active ... -
Structural and Funtional Studies on VitaminB1-Dependent Human and Bacterial Transketolases
(2012-08-24)Transketolases (TKs, EC 2.2.1.1) are ubiquitous enzymes in cellular carbohydrate metabolism that require the cofactor thiamin diphosphate for catalytic activity. TKs are involved in numerous metabolic pathways whereas the ... -
Generation of Novel Photochromic GFPs: Fluorescent Probes for RESOLFT-type Microscopy at Low Light Intensities
(2012-05-23)The resolution of a conventional light microscope is limited by diffraction. Hence, light microscopy failed to discern objects that are closer together than half the wavelength of light. STED (STimulated Emission ... -
An mRNA degradation complex in Bacillus subtilis
(2011-12-14)In every organism the degradation of mRNAs is a fundamental process. This step not only recycles nucleotides but also adjusts gene expression due to the availability of the mRNA templates. The main players in this process ... -
Structural characterization of the lysosomal 66.3 kDa protein and of the DNA repair enzyme Mth0212 by means of X-ray crystallography
(2009-06-17)This PhD thesis is divided into two parts both dealing with structural characterization of macromolecules by means of X-ray crystallography. Part I concerns the lysosomal 66.3 kDa protein ...