Browsing Fakultät für Biologie und Psychologie (inkl. GAUSS) by Referee "Wimmer, Ernst A. Prof. Dr."
Now showing items 21-40 of 94
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Application of RNA Interference for the Study of Lethal Genes and Dynamic Processes
(2016-02-08)RNA interference (RNAi) is a highly conserved cellular mechanism and in the last years it has become to a major tool for functional analyses of genes in different species. Moreover, RNAi has recently been suggested as a ... -
Comparative DNA‐Protein Interaction and Epithelial Tight Junctions Modulation Potential of Immunosuppressive Regime
(2016-01-28)Mycophenolic acid (MPA) is an important immunosuppressive drug (ISD) prescribed to prevent graft rejection in the organ transplanted patients. However, its use is sporadically linked to the leak flux diarrhea and other ... -
The Role of 2',3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNP) in the Peripheral Nervous System
(2015-10-19)In the peripheral nervous system (PNS) Schwann cells (SC) engulf, insulate and support motor and sensory axons. Nonmyelinating SC are associated with axons smaller than 1 µm in diameter, whereas myelinating SC form a compact ... -
Biology of odoriferous defensive stink glands of the red flour beetle Tribolium castaneum
(2015-09-15)Chemical warfare is a very common defense strategy in the insect world. A broad range of coleopteran beetles react to predators, invaders, and parasitic microbes with the release of toxic and repellent substances, which ... -
Analyses of improved long term memory in SHARP1 and SHARP2 double knockout mice
(2015-09-15)The transition of recent experiences into stable and remote memory traces is an important task that mainly occurs during sleep. Sleep-associated consolidation of remote long-term memory is based on cortical networks that ... -
Identifizierung neuer Coregulatoren von SOX9 und RUNX2 in chondrogenen Progenitorzellen in der Osteoarthrose
(2015-06-23)Osteoarthritis is a degenerative disease of the joints. It is characterized by a successive destruction of the articular cartilage and surrounding structures. Osteoarthritis is the most common musculoskeletal joint disease ... -
Functional Analysis of Two Major Sperm Tail Proteins Identifies ODF1 as Being Essential for the Tight Linkage of the Sperm Head to the Tail via SPAG4 and ODF2 as A Component of the β-catenin Destruction Complex
(2015-04-02)In the mammalian sperm tail, the outer dense fibers (ODFs) are accessory fibers accompanying the axonemal tubuli doublets on their outer site. The ODFs are composed of at least 14 polypeptides of which only a few have been ... -
Identifizierung schutzvermittelnder Antigene von Aspergillus fumigatus für eine Impfstoffentwicklung zur Verhütung invasiver Aspergillosen bei Leukämie-Patienten
(2015-01-23)A.fumigatus is the most common cause of invasive, usually fatal aspergillosis in severely immunocompromised patients. A natural resistance to the fungus is mediated by the innate immune system. Additionally, an acquired ... -
Modelling genetic heart diseases with patient-specific induced pluripotent stem cells
(2014-09-23)Brugada syndrome (BrS), a cardiac genetic disease, is one of the major causes of sudden cardiac death in healthy young people. However, the underlying electrophysiological and molecular mechanisms have not been completely ... -
Systematic Reverse Genetic Screen to Identify Novel Genes Required for Anterior Patterning of the Red Flour Beetle Tribolium castaneum
(2014-08-19)The formation of two main body axis is a crucial event during bilaterian de-velopment and has been in the focus of research for many years. The vinegar fly Drosophila melanogaster served as an excellent model organism for ... -
Zelltyp-spezifische Interaktionen von Toxoplasma gondii und murinen Skelettmuskelzellen in vitro
(2014-06-26)Toxoplasma gondii is one of the most common intracellular protozoan parasites worldwide and an important human pathogen. Its life cycle includes three stages: sporozoites, tachyzoites and bradyzoites. While sporozoites are ... -
Patient-Specific Induced Pluripotent Stem Cell Models of Parkinson’s Disease
(2014-06-02)Parkinson’s disease (PD) is one of the common neurodegenerative diseases. In particular, it affects the elderly and associates with the movement disorder. The hallmarks of PD are progressive loss of midbrain dopaminergic ... -
Planar Cell Movements and Axial Patterning During Early Gastrulation of the Rabbit Embryo
(2014-05-22)During mammalian gastrulation cellular mechanisms such as cell movements and cell proliferation give rise to the primitive streak and thereby fix the body axes and create the basis for the ‘milieu intérieur’. Although many ... -
Human and mouse meniscus progenitor cells and their role in meniscus tissue regeneration
(2014-05-19)Osteoarthritis (OA) is a degenerative disease of hyaline cartilage. The cartilage is an avascular tissue, once damaged it is difficult to repair. Articular cartilage is responsible for the smooth, frictionless, and painless ... -
Expression screen for Wnt signaling-like phenotypes identifies Fam132b as a novel inhibitor of BMP signaling in Xenopus
(2014-03-13)The canonical Wnt signaling pathway is known to regulate multiple developmental events,including development of the digestive tract. In this study, we wanted to systematically analyze the role of the Wnt/β-Catenin signaling ... -
Funktionelle Analyse des Transkriptionsfaktors Pitx3 während der Entwicklung dopaminerger Neuronen im murinen Mittelhirn
(2013-09-04)The transcription factor PITX3 is expressed only in postmitotic mDA neurons of the midbrain and shows a complete co-expression of TH in the VTA and the SN. At a loss to PITX3 expression (aphakia mouse) the mDA neurons of ... -
The role of adipose tissue circadian clocks in metabolic maintenance
(2013-07-25)The day-night recursion generated by rotation of the Earth around its axis imposes 24 hour rhythm of light and temperature changes on all organisms. To cope with these changes and associated challenges biological species ... -
Differential gene expression of chemokines in KRAS and BRAF mutated colorectal cell lines: Role of cytokines
(2013-06-07)Background: Worldwide, colorectal cancer is the third most common malignancy. The development of the colorectal cancer (CRC) is a multistep process that involves e.g. an accumulation of mutations in tumor-growth promoting ... -
Molecular and Functional Characterization of Programmed Cell Death (PCD) in Toxoplasma gondii
(2013-05-06)Toxoplasma gondii is a protozoan parasite which leads to widespread infections in humans and animals worldwide. Infection is typically asymptomatic in immunocompetent hosts, but may lead to severe symptoms in immunocompromized ... -
Biotechnological approaches to fight fruit flies of agricultural importance
(2012-10-08)Tephritid fruit flies destroy fruits and vegetables, causing tremendous economic losses and bringing a barrier to trade in fruits, vegetables and their associated products. The Sterile Insect Technique (SIT), a target-specific ...