Browse by type "doctoralThesis"
Now showing items 21-40 of 1543
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Effects of climate change and land use on the structure and function of earthworm communities
(2024-05-07)Human activity-induced global change is increasingly threatening biodiversity and composition of species assemblages worldwide, which reduces ecosystem resilience and provokes concerns about ecosystem functions. Over the ... -
Macromolecules in Motion by High-resolution Cryo-EM
(2024-05-06)Protein synthesis, the translation of the genetic code into a defined sequence of amino acids, is a central, highly dynamic and regulated step in gene expression. The well-defined bacterial translation system enables to ... -
Causes and consequences of female competition in redfronted lemurs (Eulemur rufifrons)
(2024-04-19)Competition among female mammals appears to be much more widespread than previously thought, and it can take on extreme forms, including eviction and even death. Nevertheless, female competition has only recently been ... -
Changes in Microbial Resources and Trophic Niches of Microarthropods in Forest Ecosystems with Elevation
(2024-03-27)Mountain forests play a major role for biodiversity conservation, carbon storage and hydrological cycling. Therefore, understanding different components of mountain forest ecosystems is essential to predict potential ... -
Holocene vegetation and environmental changes with a focus on peat ecosystems in southwestern and northeastern Amazonia
(2024-03-27)Amazon rainforests are well-known for playing a significant role in the climate, hydrological cycle, and biodiversity on earth. Recent investigations found that Amazonia may contain the largest peat carbon (C) stock in the ... -
A novel rRNA quality control function for Npl3 in Saccharomyces cerevisiae
(2024-03-25)In all domains of life, ribosomes are essential complexes that are the sole source for protein synthesis. Ribosome biosynthesis, the most energy-consuming process in a cell, has to be tightly regulated. Misregulation ... -
Characterization of the molecular interaction between α-synuclein and prion protein
(2024-03-21)The interaction between α-synuclein (aSyn) and prion protein (PrP) has been implicated in the pathogenesis of synucleinopathies. However, the nature of this interaction remains poorly understood. Here, we employed a ... -
Investigation into gene regulatory networks governing the development and maintenance of the planarian reproductive system
(2024-03-20)Regulation of gene expression is a fundamental mechanism allowing the existence of complex living systems. This regulation takes shape in the form of hierarchical gene regulatory networks (GRNs), culminating in the binding ... -
Assessment of the toxicity of inorganic and organic pollutants using the benthic alga Closterium ehrenbergii
(2024-03-20)In this thesis, Closterium ehrenbergii was selected as test species for the assessment of the toxicity of environmentally relevant pollutants towards a representative of benthic algae. Therefore, a miniaturized bioassay ... -
The prothoracic repellent glands of stick and leaf insects: Reconstructing the morphological and chemical evolution of an elaborate arthropod defensive system
(2024-03-11)Stick and leaf insects (Phasmatodea) form a diverse lineage of large herbivorous arthropods inhabiting predominantly tropical and subtropical regions. These insects are well known for their impressing camouflage capabilities, ... -
The complex formation of RNase P and RNase MRP in Saccharomyces cerevisiae
(2024-03-06)Ribonucleoproteins comprise a class of complexes that consist of RNAs and proteins. Riobozymes are catalytically active ribonucleoproteins that play a key role in the maturation of various RNAs. A prominent example is ... -
Optimization of experimental procedures for the assessment of auditory cognition in non human primates
(2024-02-23)In a loose sense, the exceptional development of technology in the past three decades has allowed researchers to drastically improve the quality and quantity of behavioral data. However, the methodological advances achieved ... -
Mechanistic differences in mouse models of heart failure with preserved ejection fraction
(2024-02-21)Heart failure (HF) is the most potent epidemic of the 21st century. Based on ejection fraction (EF), HF has been classified into two distinct entities; heart failure with reduced EF (HFrEF) and heart failure with preserved ... -
Characterization of human Neuropsin (hOPN5) and development of new mutants for optogenetic stimulation of the Gq signaling cascade
(2024-02-20)Gq signaling plays a pivotal role in the physiological adaptation of cellular behavior based on the individual body's needs and it is also involved in the pathogenesis of many diseases including cancer, autoimmunity, ... -
The manifestations and interdependence of social and physiological aging in wild female Assamese macaques (Macaca assamensis)
(2023-12-11)Aging is a multifaceted process which increases the probability of death, and although there can be only one outcome, the ways to get there are diverse. Accumulating evidence of aging in natural animal populations has shed ... -
The enzymatic product of SH2 domain-containing inositol 5-phosphatases supports the fitness of BCR-dependent Burkitt lymphoma cells by promoting the energy metabolism
(2023-11-23)Burkitt lymphoma (BL) is an aggressively growing neoplasm owing to an over expression of the MYC oncogene and exploitation of the tonic B cell receptor (BCR) signaling for its survival. While it is known that the survival ... -
Is increased Na+ influx a cause of mitochondrial redox stress, cardiomyopathy, and a therapeutic target?
(2023-11-09)Maintaining balanced Na+ levels is critical for normal functioning of cardiomyocytes, including contractions, excitation-contraction coupling (ECC), and metabolism. The NaV1.5-F1759A (human) mutation, which increases ... -
Effects of agri-environmental measures in intensively managed farmland on the soil seed bank, butterflies and carabid beetles in Germany - Influence of local conditions and surrounding landscape on biodiversity
(2023-09-26)Monitoring of the soil seed bank, butterflies, and carabid beetles, representing different trophic groups, provides an insight into the broader effects of agri-environmental measures in intensively used arable landscapes. ... -
Inter-and Intraindividual Variation in Emotion Recognition: Investigating the Role of the Ovulatory Cycle, Sex, and Personality
(2023-09-18)Previous research has shown that emotion recognition varies within and between individuals, influenced by physiological and psychological factors such as hormones, biological sex, and dispositional traits. However, ... -
Characterization of Npl3 as a 5'- and 3'- quality control factor
(2023-09-11)Maturation of RNA polymerase II transcripts consists of 5’-capping, splicing, cleavage and 3’-polyadenylation. These processes can generate faulty transcripts that have to be retained in the nucleus to be degraded. An mRNA ...